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A Novel Chitosan-based Sponge Coated with Self-assembled Thrombin/Tannic Acid Multilayer Films as a hemostatic dressing

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Chinese Journal of Polymer Science 2015年第2期33卷 284-290页

作者： Xiao-fei Huang Jing-wei Jia 王征科胡巧玲 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University

In order to prepare a novel hemostatic dressing for uncontrolled hemorrhage, a porous chitosan sponge was coated with self-assembled（thrombin/tannic acid）n films, which were based on hydrogen bonding interactions between thrombin and tannic acid at physiologic p H. According to the whole blood clotting test, the coated chitosan sponges showed a significantly high rate of blood clotting due to the addition of thrombin. On the other hand, the storable half-life of immobilized thrombin is extended to 66.9 days at room temperature, which is 8.5 times longer than unfixed thrombin. It is because of the immobilization effect of, not only the porous structure of chitosan sponge but also the interactions between thrombin and tannic acid. In addition, the tannic acid has similar antibacterial effect to chitosan. Therefore, it is an excellent combination of chitosan, thrombin and tannic acid. Besides, all of materials in this research have been approved by the United States Food and Drug Administration（FDA）. So the chitosan-based sponge is a promising candidate dressing for uncontrolled hemorrhage due to its storable, bio-safe and highly effective hemostatic properties.

关键词： Chitosan Thrombin Tannic acid Layer-by-Layer assembly hemostatic dressing

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A robust polyacrylic acid/chitosan cryogel for rapid hemostasis

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Science China(Technological Sciences) 2022年第5期65卷 1029-1042页

作者： SHI MingYue JIANG LiJie YU ChaoJie DONG XiaoRu YU QingYu YAO MengMeng HE ShaoShuai YUE ZhiWei YAO FangLian ZHANG Hong SUN Hong LI JunJie School of Chemical Engineering and Technology Tianjin UniversityTianjin300350China School of Basic Medical Sciences North China University of Science and TechnologyTangshan063210China Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjin300350China

Currently,it is a challenge to develop hemostatic materials with high water absorption capacity and anti-fatigue properties for quickly preventing massive hemorrhage from arteries and visceral organs.A series of polyacrylic acid/chitosan(PAA/CS)cryogels were prepared by a cryostructurization technique to improve mechanical performance and hemostatic efficiency of chitosan(CS).In this system,the chemically cross-linked PAA network was used as a framework to improve water absorption behaviors and mechanical *** CS network was co-blended by hydrogen bonding and electrostatic interactions,both of which synergistically promoted *** cryogels had high porosity(>94%),rapid water absorption rate(2000%),outstanding mechanical strength,and fatigue ***,the results of cytotoxicity and hemolysis demonstrated that the cryogels had good ***,the PAA/CS cryogels exhibited superior whole blood coagulation ability and red blood cell and platelet adhesion ability compared to those of commercial hemostatic dressing(gauze,gelatin sponges,and CS sponges).Based on these results,mouse femoral artery hemorrhage models and liver hemorrhage models were prepared to investigate the hemostatic ability of the prepared PAA/CS *** suggested that the hemostatic ability of PAA5/CS cryogels was superior to that of commercial hemostatic ***,the PAA/CS cryogels showed potential application in preventing massive hemorrhage from arteries and visceral organs.

关键词： hemostatic dressing chitosan polyacrylic acid cryogel

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