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Relationship between the Clinical Features and the Viral Antigen in the Extremity Blood of the Patients with hemorrhagic fever with Renal Syndrome

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1999年第1期19卷 71-72页

作者：韩春荣曾令兰罗端德 Department of Infectious Diseases Xiehe Hospital Tongji Medical University Wuhan 430022

Summary: The direct immunogold silver staining (D IGSS) method was used to detect the viral antigen in the extremity blood of 67 cases of hemorrhagic fever with renal syndrome. The positive rate of viral antigen was the highest during the fever, hypotension and oligouria phrase; and the rate dropped gradually during the polyuria and convalescent phase. It is suggested that clinical staging was positively related with the percentage of the viral antigen positive cells (P<0.001). It is concluded that the positive rate was related to the extent of the injuries by direct viral attack and immune reaction. The D IGSS was proved to be fast, simple, economical, with high sensitivity and specificity.

关键词： hemorrhagic fever renal syndrome clinical staging immunogold silver staining

Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry

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Acta Pharmaceutica Sinica B 2020年第5期10卷 789-798页

作者： Ke Tang Xiaoyu Zhang Ying Guo State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacology Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The limited treatment options for the increasing occurrence of Lassa hemorrhagic fever in West Africa poses an urgent need for the discovery and development of novel *** supplements,especially natural products that are edible and safe for human use,are a good source of drug discovery with potential for uncovering novel applications,In this study,we tested 40 natural products of dietary supplements and identified capsaicin,a common dietary supplement abundant in chili peppers,as an inhibitor of Lassa virus(LASV)entry with EC5,of 6.9-10.0μmol/L using an HIV based pseudo virus *** inhibits the entry of five LASV strains but not against the Old World arenavirus lymphocytic choriomeningitis virus(LCMV),showing a preferential activity against *** inhibits LASV entry by blocking the pH dependent viral fusion through affecting the stable signal peptide(SSP)-GP2 transmembrane(GP2TM)region of the LASV surface *** study revealed the key residues Ala25,Val431,Phe434 and Val435 in SsP-CP2TM region in capsaicin’s antiviral *** study for the first time reveals a direct acting antiviral effect of capsaicin against the hemorrhagic fever causing LASV,providing detailed interaction hot spots in the unique SSP-GP2TMinterface of LASV glycoprotein that is crucial in fusion inhibition,and offering a new strategy in discovering and developing antivirals from natural products that are safe for human use.

关键词： Lassa virus Fusion inhibitor Capsaicin Dietary supplement Natural product antivirals Viral entry hemorrhagic fever SSP-GP2TM region

New focus of Kyasanur Forest disease virus activity in a tribal area in Kerala, India, 2014

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Infectious Diseases of Poverty 2015年第1期4卷 122-125页

作者： Babasaheb V Tale Anukumar Balakrishnan Pragya D Yadav Noona Marja Devendra T Mourya National Institute of Virology(NIV) 20-ADr Ambedkar RoadPuneMaharashtra 411001India National Institute of Virology Kerala Unit AlappuzhaKeralaIndia Deputy District Medical Officer(Public Health) MalappuramKeralaIndia

Background:Kyasanur Forest disease(KFD)is a febrile illness characterized by hemorrhages,and is reported endemic in the Shimoga district in Karnataka state,*** is caused by the KFD virus(KFDV)of the family Flaviviridae,and is transmitted to monkeys and humans by Haemaphysalis ***:We investigated a new focus of KFD among tribals in a reserve forest in Kerala state,India.A suspected case was defined as a person presenting with acute fever,headache,or *** sera were collected and tested for KFDV RNA by real-time RT-PCR,RT-nPCR assay,and anti-KFDV IgM and IgG by *** index case was a tribal woman with febrile illness,severe myalgia,gum bleeding,and ***-KFDV IgM antibody was detected in acute and convalescent sera of the index case along with IgG in the second *** of her family members reported *** verbal autopsy,two more fatal cases were identified as probable primary *** serum from a case in the second cluster was detected positive for KFDV RNA by real time RT-PCR(Ct=32)and *** of E gene showed highest similarity of 98.0%with the KFDV W-377 isolate nucleotide and 100%identity with amino ***-KFDV IgM was detected in the serum of one family member of the index case,as well as in one out of 17 other ***:We confirmed a new focus of KFDV activity among tribals in a reserve forest in the Malappuram district of Kerala,India.

关键词： Kyasanur Forest disease hemorrhagic fever Arbovirus Flavivirus India Ticks

Prediction of Acute Renal Failure in Dengue fever Patients

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Open Journal of Urology 2022年第2期12卷 99-106页

作者： Salwa Abd Almoneim Mohammed Ali Mohammed Omer Abaker Gibreel Nazik Sir El Khatim Bakhit Suliman Ali Khider Ali Mohammed Bakri Yousif Mohamed Nour Department of Clinical Chemistry Eastern Sudan College of Medical Science and Technology Port Sudan Sudan Department of Clinical Chemistry Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Hematology and Immunohematology Port Sudan Ahlia College Port Sudan Sudan Department of Microbiology Eastern Sudan College of Medical Science and Technology Port Sudan Sudan

Background: Dengue virus (DENV) infection is caused by an arboviral strain and is transmitted by the mosquito Aedes aegypti which is found in Sudan especially Red Sea and Kassala states in the east. The disease is known to cause renal disturbances and a thorough understanding of that will potentially help in the prediction, diagnosis and treatment of the disease. Methods: This study is a prospective observational cross sectional study conducted in the Eastern Sudan College of Medical Science and Technology and Port Sudan Teaching Hospital. 200 confirmed Dengue virus infected patients along with 200 healthy appearing adults (control) were enrolled for the study. Statistical analysis was carried out after the collection of patients’ demographic, clinical, and investigational data including serum urea and creatinine values. Ethical approval was obtained from the ministry of health, Red Sea state and informed written consent was obtained from each participant. Results: The highest incidence of DENV infection was observed in individuals of the middle age group (29%). Elevated blood urea levels were detected in 10 (5%) patients while elevated creatinine levels were seen in 17 (8.5%) patients. Although fallen within reference ranges found in the literature, mean blood urea and creatinine values differed significantly between patients and controls and between different categories of the disease. Mean blood urea concentration showed a statistically significant difference between the control (22.3 mg/dl) and the test (28.4 mg/dl) (P value Conclusion: We strongly conclude that renal involvement is not uncommon in Dengue fever and that blood urea and creatinine evaluation should be considered in the counseling of DENV infection patients. Patients need to be subjected to necessary laboratory investigations associated with acute kidney injury to decrease the rate of morbidity and mortality associated with the disease.

关键词： Dengue Virus Acute Kidney Injury hemorrhagic fever Shock Syndrome Eastern Sudan

Liver Damage during Dengue fever in Ouagadougou

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Open Journal of Gastroenterology 2022年第9期12卷 221-231页

作者： Alice Nanelin Guingané Judith Ouango Abdoulaye Sourabié Christiane Couna Bere Roger Sombié Alain Bougouma Abdel Karim Sermé Aboubacar Coulibaly Sosthène Somda Department of Hepato-Gastroenterology CHU Bogodogo Burkina Faso Hepato-Gastroenterology Department CHU Yalgado Ouédraogo Burkina Faso

Dengue fever is widespread in all tropical and subtropical areas of the world and is the main public health problem posed by arboviroses. In Burkina Faso, an outbreak of dengue serotype “DENV-2”, which is responsible for severe forms of dengue, has been reported. In this study, we will discuss liver damage during this disease. The aim of this study was to describe the sociodemographic, diagnostic, therapeutic and evolutionary aspects of dengue patients with hepatic cytolysis. Patients and Methods: This was a prospective cross-sectional study of dengue disease in 2 facilities in the city of Ouagadougou. The study was spread over a period of 3 months from August to November 2019. The study population consisted of all patients hospitalised for dengue with a positive AgNS1 and/or IgM rapid diagnostic test (RDT) and presenting signs of liver damage. Results: During our study period we recruited 134 patients with dengue fever of which 93 or 69.4% had at least one elevated transaminase. The sex ratio was 1.90 and the average age was 35 years. Symptoms of liver damage were rare with right hypochondrial pain in 4.30% of cases and jaundice in 1.07% of cases. Dengue haemorrhagic fever was found in 5 patients. IgG was negative in 77.42%. The majority of patients (44% or 47.31%) had at least one transaminase value elevated to the upper limit of normal (ULN);and a minority, 14 patients or 15.06%, had transaminases above 10 ULN. A small proportion of patients had hepatocellular failure 26.92% with a lowered prothrombin level. Ninety-four per cent (94.62%) of the patients received analgesics. Level 1 analgesic (paracetamol) was the most widely administered, particularly in 76 patients (86.36%). More than half of the patients (57.14%) had a length of stay of less than or equal to 3 days and the outcome was favourable in 91.40%. Conclusion: Dengue virus causes alterations in the liver parenchyma. The degree of liver damage is variable. As clinical symptoms are almost non-existent, th

关键词： Dengue fever Liver Damage Cytolysis hemorrhagic fever

Ebola, the killer virus

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Infectious Diseases of Poverty 2015年第1期4卷 146-151页

作者： Haider Ghazanfar Fizza Orooj Muhammad Ahmed Abdullah Ali Ghazanfar Shifa College of Medicine Pitras Bukhari Road H-8/4IslamabadPakistan Federal Medical and Dental College Prime Minister’s National Health ComplexChak ShahzadIslamabadPakistan

Ebola virus disease(EVD)has mostly affected economically deprived countries as limited resources adversely affect a country’s infrastructure and *** into the factors that led to the widespread outbreak,setting forth plans to counter EVD cases in developing countries,and devising definitive measures to limit the spread of the disease are essential steps that must be immediately *** this review we summarize the pathogenesis of EVD and the factors that led to its *** also highlight interventions employed by certain countries that have successfully limited the epidemic,and add a few preventive measures after studying the current *** to the available data,barriers to prevent and control the disease in affected countries include irresolute and disorganized health systems,substandard sanitary conditions,poor personal hygiene practices,and false beliefs and stigma related to *** public health sector along with the respective chief authorities in developing countries must devise strategies,keeping the available resources in mind,to deal with the outbreak before it *** a first step,communities should be educated on EVD’s symptoms,history,mode of transmission,and methods of protection,including the importance of personal hygiene practices,via seminars,newspapers,and other social media.A popular opinion leader(POL)giving this information would further help to remove the misconception about the nature of the disease and indirectly improve the quality of life of affected patients and their families.

关键词： Ebola hemorrhagic fever Epidemiology Ebola virus/physiology hemorrhagic fever Ebola/transmission Ebola/prevention and control

Significance of Serum Electrolyte Pattern in an Eastern Sudanese Dengue fever Patients Population

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Open Journal of Medical Microbiology 2022年第1期12卷 1-10页

作者： Salwa Abd Almoneim Mohammed Ali Mohammed Omer Abaker Gibreel Nazik Sir El Khatim Bakhit Suliman Ali Khider Ali Mohammed Bakri Yousif Mohamed Nour Department of Clinical Chemistry Eastern Sudan College of Medical Science and Technology Port Sudan Sudan Department of Clinical Chemistry Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Hematology and immunohematology Port Sudan Ahlia College Port Sudan Sudan Department of Microbiology Eastern Sudan College of Medical Science and Technology Port Sudan Sudan

Background: Dengue virus (DENV) infection is caused by an arboviral strain and is transmitted by the mosquito Aedes Egyties which is found in Sudan especially Red Sea and Kassala states in the east. In the year 2020 there was a significant outbreak in the both states. The disease is known to cause renal and electrolyte disturbances and a thorough understanding of that which will potentially help in the prediction, diagnosis and treatment of the disease. Methods: This study is a prospective observational cross sectional study conducted in the Eastern Sudan College of Medical Science and Technology and Port Sudan Teaching Hospital. 200 confirmed Dengue virus infection patients along with 200 healthy appearing adults (as a control) were enrolled for the study. Statistical analysis was carried out after the collection of patients’ demographic, clinical, and investigational data including electrolyte values. Results: The highest incidence of DENV infection was observed in individuals of the middle age group (29%). Although fallen within reference ranges found in the literature, mean serum electrolyte values differed significantly between patients and controls and between different categories of the disease. For our patients, hyponatraemia was seen in 43.5%, hypokalaemia in 37%, hypocalcaemia in 30%, hypophosphataemia in 12% and low magnesium concentrations in 13%. Mean serum sodium concentration differed in the control (138.2 mmol/l) from in the test (132.5 mmol/l) (P. value 0.02). Similarly, mean serum potassium in the control (3.97 mmol/l) differed significantly (P. value 0.01) from test (3.30 mmol/l). Mean calcium and phosphorus (8.80 and 3.50 mg/dl) in the control were also differed from test (8.51 and 3.30), (P. values 0.02 and 0.004, respectively). In contrast, serum magnesium (mg/dl) in the control group (1.96) showed no significant difference from that of test group (1.90) (P. value 0.08). The biochemical parameters studied were neither affected by age nor by gen

关键词： Dengue Virus hemorrhagic fever Dengue Shock Syndrome Electrolytes Eastern Sudan

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新疆出血热病毒S基因片段的测序和分析

中国人兽共患病学报 2004年第Z1期21卷 35-36页

作者：唐青 C.Prehaud M.Bouloy 冯崇慧赵秀芹陈化新杨为松中国疾病预防控制中心病毒病预防控制所北京100052 　　　　　　

　　新疆出血热(Xinjiang hemorrhagic fever,XHF)既克里米亚--刚果出血热(Crimean Congo hemorrhagic fever,CCHF)在我国新疆地区严重流行,病死率较高;近几年XHF的抗体也在许多省区的家畜或人血清中发现,是又一个不容忽视的公共卫生问... 详细信息

　　新疆出血热(Xinjiang hemorrhagic fever,XHF)既克里米亚--刚果出血热(Crimean Congo hemorrhagic fever,CCHF)在我国新疆地区严重流行,病死率较高;近几年XHF的抗体也在许多省区的家畜或人血清中发现,是又一个不容忽视的公共卫生问题.为认识XHF病毒的本质,从分子水平揭示其基因结构与功能的关系,寻找传播及流行的原因,对1965年分离自我国首例病人及1984年分离自蜱的两株XHF病毒进行了S基因片段的克隆测序和分析.结果两株病毒核苷酸序列同源性为96.7%,与已经发表的1968年分离自我国蜱(HY13)和羊(C68031)的两株病毒核苷酸序列同源性均较高(96.7%～99%);与其它CCHF病毒相比S基因同源性为77.4%～92.7%.计算机绘出的系统发生树状图显示我国分离的四株病毒形成一单个群体并进一步分为三组,提示流行源自我国.……

关键词：新疆出血热病毒 hemorrhagic fever 序列同源性基因结构与功能核苷酸基因同源性系统发生卫生问题克隆测序克里米亚基因片段分子水平树状图人血清计算机病死率显示首例群体