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Liver diseases in pregnancy: Diseases unique to pregnancy

World Journal of Gastroenterology 2013年第43期19卷 7639-7646页

作者： Khulood T Ahmed Ashraf A Almashhrawi Rubayat N Rahman Ghassan M Hammoud Jamal A Ibdah Division of Gastroenterology and Hepatology University of Missouri-ColumbiaColumbiaMO 65212United States

Pregnancy is a special clinical state with several normal physiological changes that influence body organs including the *** disease can cause significant morbidity and mortality in both pregnant women and their *** review summarizes liver diseases that are unique to *** discuss clinical conditions that are seen only in pregnant women and involve the liver;from Hyperemesis Gravidarum that happens in 1out of 200 pregnancies and Intrahepatic Cholestasis of Pregnancy(0.5%-1.5%prevalence),to the more frequent condition of preeclampsia(10%prevalence)and its severe form;hemolysis,elevated liver enzymes,and a low platelet count syndrome(12%of pregnancies with preeclampsia),to the rare entity of Acute Fatty Liver of Pregnancy(incidence of 1 per 7270 to 13000deliveries).Although pathogeneses behind the development of these aliments are not fully understood,theories have been *** propose the special physiological changes that accompany pregnancy as a *** suggest a constellation of factors including both the mother and her fetus that come together to trigger those unique *** a timely and accurate diagnosis of such conditions can be *** timing of the condition in relation toward which trimester it starts at is a *** diagnosis can be made using specific clinical findings and blood *** entities have well-defined criteria that help not only in making the diagnosis,but also in classifying the disease according to its *** of these conditions range from simple medical remedies to measures such as immediate termination of the *** specific conditions,it is prudent to have expert obstetric and medical specialists teaming up to help improve the outcomes.

关键词： Liver Pregnancy Hyperemesis gravidarum Intrahepatic cholestasis hemolysis,elevated liver enzymes,and a low platelet count Preeclampsia Eclampsia Acute fatty liver

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