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Does Anemia Cause QT Prolongation in Patients wit hematologic disorders？

Chinese Medical Journal 2015年第24期128卷 3385-3386页

作者： Yu-Dong Fei Yi-Gang Li William Surkis Li Zhang Department of Cardiology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Lankenau Medical Center Lankenau Institute for Medical Research Sydney Kimmel Medical College at Thomas Jefferson University Philadelphia PA USA

To the Editor： Patients with long QT syndrome have an increased risk of torsades de pointes, ventricular fibrillation, and sudden death. It has been reported in recent studies that sickle cell disease, a specific type of anemia, is associated with acquired long QT syndrome （ALQTS）, and reduced hemoglobin （Hgb） level is correlated with a longer QT interval in these patients.

关键词： QT syndrome increased risk hematologic disorders

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hematological disorders during Chronic Kidney Disease Stages 3 to 5 Non-Dialysed in Cameroon

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Open Journal of Nephrology 2020年第2期10卷 61-72页

作者： Francois Folefack Kaze Mathurin Pierre Kowo Irene Nintcheu Wagou Mahamat Maimouna Hermine Danielle Menye Ebana Fouda Marie Patrice Halle Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Higher Institute of Health Sciences Bangangté Cameroon Department of Clinical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Introduction: Haematological disorders are common complications of chronic kidney disease (CKD) leading by anemia which increase with the severity of the disease. Objective: Assess the haematological profile of CKD patients stages 3 to 5 non-dialysed seen at the first nephrology consultation in Cameroon. Patients and Methods: A hospital-based cross-sectional study was conducted from February to July 2018 at the nephrology unit of the Yaounde University Teaching Hospital and Douala General Hospital. All adults’ (≥18 years old) patients who provided a written informed consent and attended their first nephrology consultation with a nephrologist diagnosis of CKD stages 3 to 5 non-dialysed were included. Clinical and paraclinical data (serum creatinine, full blood count, reticulocytes count, iron status, vitamin B12 and folates count, and bleeding time) were collected. Parametric, non-parametric and correlations tests were used to compare variables. Results: We included 105 (59% males) participants with a mean age of 55.2 ± 13.6 years divided into 20 (19%), 36 (34.3%) and 49 (46.7%) respectively in stage G3, G4 and G5 of CKD. The profile of hematological abnormalities was anemia (86.7%), leucopenia (15.2%), hyperleucocytosis (6.7%), thrombopenia (23.8%), thrombocytosis (3.8%) and prolonged bleeding time (13.3%) without any association with the stage of CKD (p > 0.05). The pattern of anemia was mainly normocytic and normochromic (59.3%) and aregenerative (92.3%) with iron deficiency found in 23 (21.9%) participants. There was no case of vitamin B12 and folates deficiency. Prolonged bleeding time was observed in 14 (13.3%) participants with a weak correlation between platelets count and bleeding time (r = 0.122). Conclusion: We observed that aregenerative normocytic normochromic anemia is the leading haematological abnormality during CKD in this setting. None of the full blood count parameters was associat

关键词： hematologic disorders Chronic Kidney Disease Cameroon

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