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helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients

World Journal of Gastroenterology 2006年第19期12卷 3038-3043页

作者： Hans-Olof Nilsson Unne Stenram Ingemar Ihse Torkel Wadstr(o|¨)m Department of Laboratory Medicine Division of Medical Microbiology Lund UniversityLundSweden Department of Pathology Lund University LundSweden Department of Surgery Lund University LundSweden

AIM： To determine whether gastric and enteric helicobacter species are associated with pancreatic cancer. METHODS： Patients with exocrine pancreatic cancer （n = 40）, neuroendocrine cancer （n = 14）, multiple endocrine neoplasia type 1 （n = 8）, and chronic pan- creatitis （n = 5） were studied. Other benign pancreatic diseases （n = 10） and specimens of normal pancreas （n = 7） were included as controls. Pancreatic tissue specimens were analyzed by helicobacter-specific PCR-assay and products were characterized by denaturing gradient electrophoresis and DNA-sequencing. From a subset of the pancreatic cancer patients, gastric and/or duodenal tissue as well as gallbladder and ductus choledochus tissue were analyzed. Gallbladder and choledochus samples were included as controls. Stomach and duodenum samples were investigated to analyze whether a gastric helicobacter might disseminate to the pancreas in pancreatic cancer patients. Pancreatic specimens were analyzed by Bacteroidesspecific PCR for detecting the translocation of indigenous gut microbes to the diseased pancreas. RESULTS： He/icobacter DNA was detected in pancreas （tumor and/or surrounding tissue） of 75% of patients with exocrine cancer, 57% of patients with neuroendocrine cancer, 38% of patients with multiple endocrine neoplasia, and 60% of patients with chronic pancreatitis. All samples from other benign pancreatic diseases and normal pancreas were negative. Thirtythree percent of the patients were helicobacterpositive in gastroduodenal specimens. Surprisingly, H. bilis was identified in 60% of the positive gastroduodenal samples. All gallbladder and ductus choledochus specimens were negative for helicobacter. Bacteroides PCR-assay was negative for all pancreatic samples. CONCLUSION： helicobacter DNA commonly detected in pancreatic cancer suggests a possible role of the emerging pathogens in the development of chronic pancreatitis and pancreatic cancer.

关键词： Pancreatic cancer helicobacter species Polymerase chain reaction DNA-sequence analysis

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helicobacter heilmannii sensu lato :An overview of the infection in humans

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World Journal of Gastroenterology 2014年第47期20卷 17779-17787页

作者： Mario Bento-Miranda Ceu Figueiredo Department of Pathology and Oncology Faculty of Medicine of the University of Porto4200-465 PortoPortugal Institute of Molecular Pathology and Immunology of the University of Porto 4200-465 PortoPortugal

helicobacter heilmannii sensu lato(*** s.l.)is a group of gastric non-helicobacter pylori helicobacter species that are morphologically indistinguishable from each *** *** the stomach of several animals and may have zoonotic *** the prevalence of these infections in humans is low,they are associated with gastric pathology,including mucosa-associated lymphoid tissue lymphoma,making them a significant health ***,the taxonomy,epidemiology,microbiology,diagnosis,and treatment of these infections will be *** gastric pathology associated with *** *** in humans will also be ***,the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be *** understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute *** *** essential for developing strategies for prevention and treatment of these infections.

关键词： helicobacter heilmannii sensu lato Gastric non-helicobacter pylori helicobacter species Pathogenesis Diagnosis Treatment Genomes

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