检索结果-南通市图书馆

The Trend of the Multidrug Resistance of helicobacter pylori strains Isolated in Chengdu

Natural Science 2022年第12期14卷 517-523页

作者： Xiaofang Li Xiaoxiao Yang Lin Zhang Yu Zhang Hongmei Wang Ziyan Zhang Fangqiong Dong Gastroenterology Unit The People’s Hospital of Pingchang Bazhong China Yongquan Street Community Health Service Center Wenjiang District Chengdu China

Background: The treatment of Hp infection has been the most popular topic of the most attention and research by gastrointestinal disease workers, and the biggest problem in the treatment of Hp infection is Hp drug resistance to antibiotics, and Hp drug resistance is the main cause of Hp eradication failure. It is severe for the multidrug resistance of Hp. Objective: To investigate the changing trend of helicobacter pylori (Hp) resistance to metronidazole, clarithromycin and amoxicillin in children and adults in Chengdu. Methods: The Hp strain determined the minimum antibacterial concentration (MIC) from 585 patients with upper gastrointestinal symptoms, metronidazole, clarithromycin and amoxicillin was measured by the E-test. Clinically isolated Hp strains were obtained by microaerobic condition culture as the diagnostic standard. Results: The Hp resistance to metronidazole and clarithromycin in children in Chengdu were: 17.65% (27/153) and 18.06 (78/432) in adults. The Hp resistance to metronidazole and amoxicillin in children in Chengdu were: 11.76% (18/153) and 13.19 (57/432) in adults. The Hp resistance to metronidazole, clarithromycin and amoxicillin in children in Chengdu were: 3.92% (6/153) and 10.41 (45/432) in adults. There were 76.92% of the strains which were resistant to metronidazole, 24.11% to clarithromycin, and 18.46% to amoxicillin. The drug resistance rate of Hp has increased year by year from 2017 to 2021 year, especially the drug resistance rate of Hp to clarithromycin and metronidazole has generally increased. Conclusions: The drug resistance rate of Hp has increased year by year from 2017 to 2021 year.

关键词： Multidrug Resistance helicobacter pylori strains Adults Children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Early genetic diagnosis of clarithromycin resistance in helicobacter pylori

引用

World Journal of Gastroenterology 2021年第24期27卷 3595-3608页

作者： Xiao-Hua Li Yong-Yi Huang Lin-Ming Lu Li-Juan Zhao Xian-Ke Luo Ru-Jia Li Yuan-Yuan Dai Chun Qin Yan-Qiang Huang Hao Chen Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology National Hospital of Guangxi Zhuang Autonomous RegionNanning Guangxi Zhuang Autonomous Region530001China

BACKGROUND The drug resistance rate of clinical helicobacter pylori(***)isolates has ***,the mechanism of drug resistance remains *** this study,drug-resistant *** strains were isolated from different areas and different populations of Chinese for genomic *** To investigate drug-resistant genes in *** and find the genes for the early diagnosis of clarithromycin *** Three drug-resistant *** strains were isolated from patients with gastritis in Bama County,*** inhibitory concentrations of clarithromycin,metronidazole,and levofloxacin were determined and complete genome sequencing was performed with ***1181 and hp1184 genes were found in these strains and then detected by reverse transcription polymerase chain *** relationships between hp1181 or hp1184 and clarithromycin resistance were ascertained with gene mutant and drug-resistant *** homology of the strains with hp26695 was assessed through complete genome detection and *** in genome sequences,gene quantity,and gene characteristics were detected amongst the three *** and analysis of the function of drug-resistant genes indicated that the RNA expression of hp1181 and hp1184 increased in the three strains,which was the same in the artificially induced clarithromycin-resistant *** gene knockout,the drug sensitivity of the strains was *** The strains showing a high degree of homology with hp26695,hp1181,and hp1184 genes were found in these strains;the expression of the genes hp1184 and hp1181 was associated with clarithromycin *** Hp1181 and hp1184 mutations may be the earliest and most persistent response to clarithromycin resistance,and they may be the potential target genes for the diagnosis,prevention,and treatment of clarithromycin *** Hp1181 and hp1184 mutations may be the earliest and most persistent response to cla

关键词： helicobacter pylori Clarithromycin-resistance Diagnostic gene Early genetic diagnosis helicobacter pylori strains

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：