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Cyclophosphamide-induced reproductive toxicity: Beneficial effects of helichrysum odoratissimum(Asteraceae) in male Wistar rats

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Journal of Integrative Medicine 2019年第5期17卷 366-373页

作者： Pierre Watcho Ismaelle Rosine Mpeck Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Georges Romeo Bonsou Fozin Pierre Kamtchouing Albert Kamanyi Animal Physiology and Phytopharmacology Laboratory University of DschangP.O. BOX 67DschangCameroon Department of Animal Organisms Biology University of DoualaP.O. BOX 24157DoualaCameroon Department of Animal Biology and Physiology University of YaoundeP.O. BOX 812YaoundeCameroon

Objective: Cyclophosphamide(CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract(AE) and methanolic extract(ME) of helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.Methods: In addition to a normal control(group 1), drugs or vehicles were administered orally to seven groups(n = 5) of rats that had already received 4-weeks of pre-treatment with CP(5 mg/[kgád], per oral administration);group 2 received CP + distilled water(10 m L/[kgád]);group 3 received CP + 5% tween 80(10 m L/[kgád]);group 4 received CP + clomiphene citrate(0.25 mg/[kgád]);groups 5 and 6 received CP + AE(50 and 100 mg/[kgád]) and groups 7 and 8 received CP + ME(50 and 100 mg/[kgád]). Animals were sacrificed on day 15, and body and sexual organ weights, sperm characteristics, testosterone level and testicular histology were evaluated.Results: The CP-treated group showed a significant reduction(P < 0.001) in the body and seminal vesicle weights, testosterone level, sperm count, sperm motility and sperm viability, but elevated(P < 0.001)sperm morphological abnormalities and testicular structure alterations, compared to the control group.Interestingly, these detrimental effects of CP were reversed by treatment with H. odoratissimum extracts.For instance, both extracts and all doses of H. odoratissimum significantly increased the sperm count(P < 0.001), sperm motility(AE, 50 mg/kg, P < 0.05;ME, 50 and 100 mg/kg, P < 0.05) and sperm viability(AE, 50 mg/kg, P < 0.001;ME, 50 and 100 mg/kg, P < 0.001) compared to the CP group. H. odoratissimum also improved plasmatic and intratesticular testosterone levels and prevented histological alterations of the testes.Conclusion: H. odoratissimum might be considered as an alternative drug to alleviate/prevent reproductive damage in cancer patients receiving CP chemotherapy.

关键词： helichrysum odoratissimum Cyclophosphamide Reproductive toxicity Rat

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Studies on Anthocyanin in Purple Flower of helichrysum bracteatum

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北京林业大学学报 1992年第S2期14卷 70-79页

作者： Yang Shaoyong Wu DixinDepartment of Landscape Gardening ,Beijing Forestry University Bi Wangfu Cao YuyingExperimental Center of For. Bio. . BFU Department of Foundation Courses. BFU

This paper puts forward a biochemical analysis of the anthocyanins in the petals of helichrysum bracteatum flower which takes a deep purple color. A pure antho-cyanin chloride crystal is obtained and identified as a cyanin glucoside by IR, UV and MS techniques. This paper also presents a study on the preservation mechanism of the flower color and flower shape according to the histochemical and anatomical characteristics of the petals.

关键词： helichrysum bracteatum. anthocyanidin anthocyanin. cyanidin cyanin

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Distribution and Current State Cenopopulations of <i>helichrysum maracandicum</i>Popov ex Kirp. in Uzbekistan

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American Journal of Plant Sciences 2019年第8期10卷 1280-1286页

作者： Alisher N. Khujanov Institute of Botany Academy Science Republic of Uzbekistan Tashkent Uzbekistan

The current state of coenotic populations of rare and endangered species of Uzbekistan helichrysum maracandicum is given. The range of species distribution is broad. The article contains 12 cenopopulations of helichrysum maracandicum in Uzbekistan, which have considerable healing properties. During the researches, no censorship marks were recorded in any cenopopulation. Approximately, 1, 5, 11 censorpopulations were found to be close to optimal conditions. This indicates that adequate amounts of precipitation in these areas throughout the year have a positive impact on the growth and development of the plant. Most of the cenopopulations were transmitted to younger and transient states.

关键词： helichrysum maracandicum Current State Cenopopulations Plant Community Uzbekistan

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