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Advanced glycation end product signaling and metabolic complications:Dietary approach

World Journal of Diabetes 2023年第7期14卷 995-1012页

作者： Mohammad Idreesh Khan Fauzia Ashfaq Abdulrahman A Alsayegh Alshaimaa Hamouda Fahmida Khatoon Tahani Nasser Altamimi Fahad Saad Alhodieb Mirza Masroor Ali Beg Department of Clinical Nutrition College of Applied Health Sciences in Ar RassQassim UniversityAr Rass 51921Saudi Arabia Clinical Nutrition Department Applied Medical Sciences CollegeJazan UniversityJazan 82817Saudi Arabia Department of Biochemistry College of MedicineUniversity of HailHail 2240Saudi Arabia Department of Family and Community Medicine College of MedicineUniversity of HailHail 2240Saudi Arabia Faculty of Medicine Alatoo International UniversityBishkek 720048Kyrgyzstan

Advanced glycation end products(AGEs)are a heterogeneous collection of compounds formed during industrial processing and home cooking through a sequence of nonenzymatic glycation *** modern western diet is full of heat-treated foods that contribute to AGE *** high in AGEs in the contemporary diet include processed cereal *** to industrialization and marketing strategies,restaurant meals are modified rather than being traditionally or conventionally ***,grilled,baked,and boiled foods have the greatest AGE *** AGE-content foods include dry nuts,roasted walnuts,sunflower seeds,fried chicken,bacon,and *** proteins and processed plant foods contain furosine,acrylamide,heterocyclic amines,and ***(2-furoil-methyl-lysine)is an amino acid found in cooked meat products and other processed *** concentrations of carboxymethyl-lysine,carboxyethyl-lysine,and methylglyoxal-O are found in heat-treated nonvegetarian foods,peanut butter,and cereal *** plasma levels of AGEs,which are harmful chemicals that lead to age-related diseases and physiological aging,diabetes,and autoimmune/inflammatory rheumatic diseases such as systemic lupus erythematosus and rheumatoid *** in the pathophysiology of metabolic diseases have been linked to individuals with diabetes mellitus who have peripheral nerves with high amounts of AGEs and diabetes has been linked to increased myelin *** resistance and hyperglycemia can impact numerous human tissues and organs,leading to long-term difficulties in a number of systems and organs,including the cardiovascular *** AGE levels are linked to all-cause mortality in individuals with diabetes who have fatal or nonfatal coronary artery disease,such as ventricular *** levels of tissue AGEs are independently associated with cardiac systolic dysfunction in diabetic patients with heart failure compared with diabetic pat

关键词： Advanced glycation end products Receptor for advanced glycation end products heat-treated diets Food safety Maillard reaction products Metabolic disorder Diabetes Cardiac complication

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