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Role of induced pluripotent stem cells in diagnostic cardiology

World Journal of Stem Cells 2021年第5期13卷 331-341页

作者： Steven B Karch Vittorio Fineschi Pietro Francia Matteo Scopetti Martina Padovano Federico Manetti Alessandro Santurro Paola Frati Massimo Volpe School of Medicine University of NevadaLas VegasNV 89102United States Department of Anatomical HistologicalForensic and Orthopaedic SciencesSapienza University of RomeRome 00185Italy Division of Cardiology Department of Clinical and Molecular MedicineSapienza University of RomeSt.Andrea HospitalVia di Grottarossa103500189 RomeItaly Department SAIMLAL Sapienza University of RomaRome 00185Italy Department of Clinical and Molecular Medicine Sapienza University of RomeRome 00197Italy

Ethical concerns about stem cell-based research have delayed important advances in many areas of medicine,including *** introduction of induced pluripotent stem cells(iPSCs)has supplanted the need to use human stem cells for most purposes,thus eliminating all ethical *** then,many new avenues have been opened in cardiology research,not only in approaches to tissue replacement but also in the design and testing of antiarrhythmic *** methodology has advanced to the point where induced human cardiomyocyte cell lines can now also be obtained from commercial sources or tissue *** studies with readily available iPSCs have generally confirmed that their behavioral characteristics accurately predict the behavior of beating cardiomyocytes in *** a result,iPSCs can provide new ways to study arrhythmias and heart disease in general,accelerating the development of new,more effective antiarrhythmic drugs,clinical diagnoses,and personalized medical *** focus on producing cardiomyocytes that can be used to replace damaged heart tissue has somewhat diverted interest in a host of other *** manuscript is intended to provide non-specialists with a brief introduction and overview of the research carried out in the field of heart rhythm disorders.

关键词： Human induced pluripotent stem cells Diagnostic cardiology heart rhythm disorders Microelectrode array Stem cell research Ethical principles

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