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Normal values of nasal NO and exhaled NO in young Chinese people aged 9 e 22 years

World Journal of Otorhinolaryngology-Head and Neck Surgery 2016年第1期2卷 -页

作者： Shaohua You Jing Zhang Yin Bai Lingchao Ji Hongtian Wang Department of 0tolaryngology Head and Neck Surgery People’s Liberation Army General Hospital Beijing 100853 China

Objective:To assess the normal levels of nasal nitric oxide (NNO) and fractional exhaled nitric oxide (FENO) in healthy Chinese young people, and to determine whether the obtained values were associated with age, sex, height, weight, BMI (body mass index) or BSA (body surface area). Methods:One hundred and twenty healthy people were selected from a total of 436 Chinese young people based on their answers to a questionnaire. An electrochemical analyzer (NIOX MINO system) was used to measure NNO and FENO. The relationship between NNO, FENO and age, sex, height, weight, BMI, BSA was analyzed using SPSS software. Results:The values of NNO were normal distributed (mean 273.5 ppb;SD 112.3). The values of FENO were non-normally (Skewed) distributed (median:14.00 ppb;interquartile range:7.00 ppb). The ob-tained NNO values were independent of age, sex, height, weight, BMI and BSA, but were positively correlated to lnFENO (FENO log base e);lnFENO values were also independent of age, height, weight, BMI and BSA, but correlated with NNO and sex. Conclusions:NNO values positively correlate with lnFENO in healthy people and the levels of each may be predicted by the other. The results of this study are expected to serve as a reference for future studies in China. Copyright a 2016 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Nitric oxide Nasal cavity Lower respiratory tract Normal value healthy people

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Relationship between the Polymorphism of the GSTP1 (rs1695) Gene and Chronic Hepatitis B Infection in Ouagadougou, Burkina Faso

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Journal of Biosciences and Medicines 2023年第11期11卷 94-107页

作者： Tilate Lare Lassina Traore Marie Simone Traore Sidnooma Véronique Zongo Pierre Zabre Mousso Savadogo Fortune D. Salah Herman Karim Sombie Pegdwendé Abel Sorgho Tégwindé Rebeca Compaore Tani Sagna Issoufou Tao Florencia Wendkuuni Djigma Dorcas Obiri-Yeboah Damintoti Simplice Karou Rogomenoma Alice Ouedraogo Teega-Wende Clarisse Ouedraogo Prosper Bado Albert Théophane Yonli Jacques Simpore Laboratoire de Biologie Moléculaire et de Génétique Université Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Normale Supérieure Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire-Virologie Institut National d’Hygiène Lomé Togo Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Centre National de la Recherche Scientifique et Technologique Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Institut des Sciences et de Technologies/Ecole Normale Supérieure Koudougou Burkina Faso Department of Microbiology and Immunology School of Medical Sciences University of Cape Coast PMB Cape Coast Ghana école Supérieure des Techniques Biologiques et Alimentaires Université de Lomé (ESTBA-UL) Lomé Togo Centre Universitaire de Gaoua Université Nazi Boni Bobo-Dioulasso Burkina Faso

Introduction: Genetic polymorphisms of some Glutathione S-Transferase (GST) which encode the enzyme responsible for the biotransformation of drugs and xenobiotics, have been associated with the risk of several pathologies that can progress to cancer such as Hepatitis B. This study aims to characterize the impact of the rs1695 polymorphism of GSTP1 gene among people with chronic Hepatitis B infection in Burkina Faso. Methods: rs1695 polymorphisms of GSTP1 gene genotyping was performed for 50 people infected with chronic Hepatitis B virus and 124 healthy people with the PCR-RFLP method. Conventional PCR was used for DNA amplification and Alw26I enzyme was used for enzymatic digestion. Results: The results show that the frequencies of AA, AG and GG genotypes are respectively 31.00%, 36.80% and 32.20% in general the study population with a mutation rate of 50.57%. However, the incidence of the AA, AG and GG genotypes are respectively 30.64%, 38.71% and 30.64% among people with chronic Hepatitis B virus infection and 32.00%, 32.00% and 36.00% among healthy people. In cases, the frequencies of the A and G alleles are 48.00% and 52.00% respectively, and in controls 50.00% each. No statistical difference was found by comparing genotypic and allelic frequencies between cases and controls (p > 0.05). Conclusion: Our study allowed us to determine the rate of GSTP1 rs1695 genotypes in the study population, cases and controls. From our analyses, GSTP1 rs1695 is not associated to chronic Hepatitis B virus infection in Ouagadougou.

关键词： Polymorphism GSTP1 Chronic Hepatitis B healthy people Burkina Faso

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