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A community-based prospective cohort study of dengue viral infection in Malaysia: the study protocol

Infectious Diseases of Poverty 2016年第1期5卷 691-699页

作者： Nowrozy Kamar Jahan Mohtar Pungut Ahmad Amreeta Dhanoa Cheong Yuet Meng Lau Wee Ming Daniel D.Reidpath Pascale Allotey Anuar Zaini Maude Elvira Phipps Quek Kia Fatt Aman Bin Rabu Rowther Sirajudeen Ahmad AbdulBasitz Ahmad Fatan Faidzal Adlee Ghafar Hamdan Bin Ahmad Iekhsan Othman Sharifah SyedHassan Jeffrey Cheah School of Medicine and health Sciences Monash University MalaysiaJalan Lagoon SelatanBandar SunwayPetaling Jaya 47500Malaysia Segamat District Public health Office Ministry of Health MalaysiaPeti Surat 102Jalan Gudang UbatKampung GubahSegamatJohor Darul Takzim 85000Malaysia Infection and Immunity Cluster Tropical Medicine and Biology PlatformMonash University MalaysiaJalan Lagoon SelatanBandar SunwayPetaling Jaya 47500Malaysia South East Asia Community Observatory(SEACO) 146 Jalan Sia Her YamSuite 601-606Wisma CentrepointSegamatJohor Darul Takzim 85000Malaysia Hospital Segamat Ministry of Health MalaysiaKM 6Jalan GenuangSegamatJohor Darul Takzim 85000Malaysia University Sains Malaysia GelugorPenang 11800Malaysia

Background:Globally,dengue infections constitute a significant public health *** recent decades,Malaysia has become a dengue hyper-endemic country with the co-circulation of the four dengue virus *** cyclical dominance of sub-types contributes to a pattern of major *** consequences can be observed in the rising incidence of reported dengue cases and dengue related *** the complex interaction of the dengue virus,its human hosts and the mosquito vectors at the community level may help develop strategies for addressing the ***:A prospective cohort study will be conducted in Segamat district of Johor State in Peninsular *** received approval from the Malaysian Medical Research Ethics Committee and Monash University Human Research Ethics *** study will be conducted at a Malaysian based health and demographic surveillance site over a 1 year period in three different settings(urban,semi-urban and rural).The study will recruit healthy adults(male and female)aged 18 years and over,from three ethnic groups(Malay,Chinese and Indian).The sample size calculated using the Fleiss method with continuity correction is ***-surveillance of participants will be undertaken to identify asymptomatic,otherwise healthy cases;cases with dengue fever who are managed as out-patients;and cases with dengue fever admitted to a hospital.A genetic analysis of the participants will be undertaken to determine whether there is a relationship between genetic predisposition and disease severity.A detailed medical history,past history of dengue infection,vaccination history against other flaviviruses such as Japanese encephalitis and Yellow fever,and the family history of dengue infection will also be *** addition,a mosquito surveillance will be carried out simultaneously in recruitment areas to determine the molecular taxonomy of circulating ***:The research findings will estimate the burden of

关键词： Dengue Community-based Prospective cohort study health and demographic surveillance site SEACO Protoco

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