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Environment & health 2023年第3期1卷 150-167页

作者： Yu Zhang Qian Hu Jiaqi Fu Xinting Li Hongjun Mao Ting Wang Tianjin Key Laboratory of Urban Transport Emission Research State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and ControlCollege of Environmental Science and EngineeringNankai UniversityTianjin 300071China

The oxygen(OPAHs),nitro(NPAHs),hydroxyl(OH-PAHs),and alkylated(APAHs)derivatives of polycyclic aromatic hydrocarbon(PAHs)are ubiquitous pollutants in the *** concentrations of NPAHs,OPAHs,OH-PAHs,and APAHs are lower than that of PAHs in the environment,but the carcinogenic abilities of the derivatives are usually 10 to 1,000-fold higher than that of parent *** are three main pathways for the exposure of polycyclic aromatic compounds to humans,including inhalation,direct contact,and *** exposure by inhalation,they are mainly distributed in the lungs,affecting lung function and causing inflammation,asthma,*** to the digestive system’s strong capacity for metabolism,intake of PAHs and the derivatives is primarily distributed in the digestive system and metabolized *** it may lead to dysplasia of these organs and even to *** skin is the primary site of direct contact with PAH *** derivatives can enter the bloodstream through all three contact pathways,thereby accumulating in various *** study aimed to summarize the influence of exposure pathways on tissue distribution and the health impact of PAH derivatives to provide references for future research and evaluation on public health.

关键词： PAH derivatives concentration tissue distribution exposure pathway health impact

Economic Valuation of health impact of PM_(10) Pollution in Beijing from 2001 to 2006

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Chinese Journal of Population,Resources and Environment 2010年第2期8卷 68-74页

作者： Zou Wenbo Zhang Shiqiu College of Environmental Science and Engineering Peking University Beijing 100871 China

In light of the practical need for research to inform policy in Beijing,this study evaluates the economic cost of the impact of PM 10 pollution in Beijing from 2001 to 2006,taking health as the main impact,and mortality as the main *** on the literature review,this study adopts relatively conservative parameters as the basis for calculating the health *** concludes that nearly 30%of mortality among registered residents above age 30 in Beijing can be attributed to PM 10 pollution,and that the economic cost equals 0.8%-1.2%of the city's GDP over the same *** is lower than the results of previous studies,but still high enough to warrant a commitment to solve the city's air pollution problem.

关键词： health impact economic valuation mortality morbidity PM10 air pollution

Uncovering the impact of alcohol on internal organs and reproductive health:Exploring TLR4/NF-kB and CYP2E1/ROS/Nrf2 pathways

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Animal Models and Experimental Medicine 2024年第4期7卷 444-459页

作者： Eason Qi Zheng Kong Vetriselvan Subramaniyan Natasha Sura Anak Lubau Pharmacology Unit Jeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaSubang JayaSelangorMalaysia Center for Global health Research Saveetha Medical CollegeSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia

This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health,elucidating the underlying mechanisms involving the Toll-like receptor 4(TLR4)/Nuclear factor kappa light chain enhancer of activated B cells(NF-kB)pathway and the Cytochrome P4502E1(CYP2E1)/reactive oxygen spe-cies(ROS)/nuclear factor erythroid 2-related factor 2(Nrf2)*** TLR4/NF-kB pathway,crucial for inflammatory and immune responses,triggers the production of pro-inflammatory agents and type-1 interferon,disrupting the balance between inflammatory and antioxidant responses when tissues are chronically exposed to ***-induced dysbiosis in gut microbes heightens gut wall permeability to pathogen-associated molecular patterns(PAMPs),leading to liver cell infection and subsequent ***,CYP2E1-mediated alcohol metabolism gen-erates ROS,causing oxidative stress and damaging cells,lipids,proteins,and deoxy-ribonucleic acid(DNA).To counteract this inflammatory imbalance,Nrf2 regulates gene expression,inhibiting inflammatory progression and promoting antioxidant *** alcohol intake results in elevated liver enzymes(ADH,CYP2E1,and catalase),ROS,NADH,acetaldehyde,and acetate,leading to damage in vital organs such as the heart,brain,and ***,alcohol negatively affects reproduc-tive health by inhibiting the hypothalamic-pituitary-gonadal axis,causing infertility in both men and *** findings underscore the profound health concerns associated with alcohol-induced damage,emphasizing the need for public awareness regarding the intricate interplay between immune responses and the multi-organ im-pacts of alcohol consumption.

关键词： alcohol health impact inflammation metabolism molecular pathways

Understand the local and regional contributions on air pollution from the view of human health impacts

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 133-143页

作者： Yueqi Jiang Jia Xing Shuxiao Wang Xing Chang Shuchang Liu Aijun Shi Baoxian Liu Shovan Kumar Sahu State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing100084China Beijing Municipal Research Institute of Environment Protection Beijing100037China Beijing Key Laboratory of Airborne Particulate Matter Monitoring Technology Beijing Municipal Environmental Monitoring CenterBeijing100048China

The source-receptor matrix of PM_(2.5)concentration from local and regional sources in the Beijing-Tianjin-Hebei(BTH)and surrounding provinces has been created in previous ***,because the spatial distribution of concentration does not necessarily match with that of the population,such concentration-based source-receptor matrix may not fully reflect the importance of pollutant control effectiveness in reducing the PM_(2.5)-related health *** demonstrate that,we study the source-receptor matrix of the PM_(2.5)-related deaths instead,with inclusion of the spatial correlations between the concentrations and the *** advanced source apportionment numerical model combined with the integrated exposure-response functions is used for BTH and surrounding regions in *** observed that the relative contribution to PM_(2.5)-related deaths of local emissions was 0.75%to 20.77%larger than that of PM_(2.5)*** results address the importance of local emissions control for reducing health impacts of PM_(2.5)particularly for local *** of regional transport to PM_(2.5)-related deaths in rural area was 22%larger than that in urban area due to the spatial pattern of regional transport which was more related to the rural *** resulted in an environmental inequality in the sense that people staying in rural area with access to less educational resources are subjected to higher impacts from regional transport as compared with their more resourceful and knowledgeable urban *** unexpected benefit from the multi-regional joint controls is suggested for its effectiveness in reducing the regional transport of PM_(2.5)pollution thus mitigating the associated environmental inequality.

关键词： PM_(2.5) Regional transport Local emissions health impact Environmental inequality

impact of Plastic Waste on the Human health in Low-Income Countries: A Systematic Review

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Journal of Environmental Protection 2024年第5期15卷 572-595页

作者： Ramde Wendkoaghenda Sophie Gbandama Koffi Kouame Pacome Gansore Aminata Camara Kelety Tolno Barthélemy Assogba Ange Wenceslas Vinciale Niare Boubacar Patrice Ngangue Institute for Interdisciplinary Training and Research in health Sciences and Education Ouagadougou Burkina Faso Regional Directorate of health and Public Hygiene of South-Central Burkina Faso Ministry of Health Ouagadougou Burkina Faso Department of health Promotion and Education Ministry of Health and Public Hygi&#232ne Ouagadougou Burkina Faso Department of Dermatology-Venorology Treichville University Hospital F&#233lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire Department of Infectious and Tropical Diseases Donka National Hospital Faculty of Health Sciences and Techniques Bamako Mali National AIDS Control Program PNLS Ministry of Health and Public Hygiene Abidjan C&#244te d&#8217Ivoire Marketing and Consumer Welfare Research Laboratory Abomey-Calavi University Cotonou Benin Regional health Directorate of the District of Bamako Ministry of Health and Social Development Bamako Mali Department of Family Medicine Faculty of Medicine and Odonto Stomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali Faculty of Nursing Sciences Laval University Quebec Canada

Background: Plastic pollution is the accumulation of waste composed of plastic and its derivatives all over the environment. Whether in the form of visible garbage or microparticles, as it slowly degrades, plastic pollution poses significant threats to terrestrial and aquatic habitats and the wildlife that call them home, whether through ingestion, entanglement or exposure to the chemicals contained in the material. Unfortunately, there is a lack of documentation on the impact of plastic waste on human health in low- and middle-income countries (LMICs). Methods: We searched five electronic databases (PubMed, Embase, Global health, CINAHL and Web of Science) and gray literature, following the preferred reporting elements for systematic reviews and meta-analyses (PRISMA), for the impact of plastic waste on human health in developing countries. We included quantitative and qualitative studies written in English and French. We assessed the quality of the included articles using the Mixed Methods Appraisal tool (MMAT). Results: A total of 3779 articles were initially identified by searching electronic databases. After eliminating duplicates, 3167 articles were reviewed based on title and abstract, and 26 were selected for full-text review. Only three articles were retained. The three articles dealt with practices likely to lead to oral exposure to plastic chemicals in human health, as well as the level of awareness of participants concerning the possible impact of plastic on human health, namely, the use of plastic baby bottles, the use of microwaves to cook food and reheat precooked food, the use of plastic bottles to store water in the refrigerator, water purifier containers with plastic bodies and plastic lunch boxes, the reuse of plastic bags and the inadequacy of treatment facilities. Conclusion: Plastic waste poses different risks to human health at every stage of its life cycle. Hence, strategies must be adopted to raise public awareness of the dangers of plastic

关键词： Human Population Plastic Waste health impact Low-Income-Countries (Humans Iatrogenic Disease Plastics Policy Recycling Waste Management)

Monitoring of the Physicochemical and Bacteriological Quality of the Water of the Gounti-Yéna Basin and Assessment of the impact on the health of the Populations

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Journal of Environmental Protection 2022年第7期13卷 459-489页

作者： Halidou Alassane Hado Adamou Mahaman Moustapha Guillaume Favreau Karmadine Hima Ibrahim Dan Dano Abdourhamane Amadou Toure Nafissa Saidou Faculty of Agronomy Abdou Moumouni University of Niamey Niamey Niger Grenoble Alpes University IRD CNRS Grenoble INP IGE Grenoble France Faculty of Science and Technology Abdou Moumouni University of Niamey Niamey Niger Medical and health Research Center Niamey Niger Quali Control Lab Niamey Niger

The Gounti Yéna valley is the main watercourse that divides the left bank of the city of Niamey into two unequal parts. The area of its watershed is estimated at about 62 km2. The objective of this study is on the one hand to evaluate the current state of the physico-chemical and bacteriological quality of the water of the Gounti Yéna basin and on the other hand to define the risks of water pollution and its origin in the face of the phenomenon of the rise in the water table of this basin by defining some health risks linked to these impacts. In order to properly carry out this work, we carried out a study of the evolution of the physicochemical and bacteriological parameters of the water of the Gounti Yéna basin during the period from November 2020 to October 2021, at three sampling points chosen from upstream to downstream of the basin then entomological surveys and among the health centers of the capital. The results obtained showed that the physico-chemical quality of water in the Gounti Yéna basin is influenced by climatic factors (precipitation and temperature) and anthropogenic actions. This study also highlighted the presence of faecal contamination in the water of the Gounti Yéna basin with a greater degree during the rainy season. This contamination remains worrying and constitutes a health risk causing waterborne diseases. The stagnation of the various bodies of water is also a favorable place for the development and spread of vector-borne diseases.

关键词： Pond Resurgence Point Flooding health impact Urban Environment

Carbon Dioxide Emissions by the Transportation Sector and Its impact on health in the Kathmandu Valley, Nepal

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Journal of Civil Engineering and Architecture 2017年第2期11卷 184-193页

作者： Kishor Shrestha Pramen P. Shrestha Geeta Shrestha General Engineering Department Montana Tech of the University of Montana Montana 59701 USA Civil and Environmental Engineering and Construction Department University of Nevada Las Vegas Nevada 89154 USA Human Rights Officer National Human Rights Commission Harihar Bhawan Lalitpur Nepal

Air pollution is one of the leading cause of death for underdeveloped as well as developed countries. In 2011, the air pollution was the second leading cause of death in one of the main hospitals of the Kathmandu Valley, Nepal, and it was the third leading cause in the United States. Burning fossil fuels for transportation was one of the major causes. Among various impacts of the air pollution, COPD （chronic obstructive pulmonary disease） was one of the main consequences. In the 570 km2 Kathmandu Valley, vehicle registration was increased from 45,871 in 1990/1991 to 570,145 in 2010/2011, an increase of over 12-fold over 20 years. The vehicle registration and number of COPD patients＇ data were collected from various government divisions. In addition, the average daily travel distance and fuel mileage data were collected with a survey with residents of the Kathmandu Valley. This paper calculates the amount of carbon dioxide （CO2） emissions by transportation sector and determines correlation between CO2 emissions and COPD patients. Results show that there was a very high level of CO2 emissions, and it was positively correlated with the number of COPD patients in the valley.

关键词： Carbon dioxide emissions health impact Kathmandu.

A systematic review of the inequality of health burdens related to climate change

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 137-153页

作者： Xinke Song Shihui Zhang Hai Huang Qun Ding Fang Guo Yaxin Zhang Jin Li Mingyu Li Wenjia Cai Can Wang State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Department of Earth System Science Tsinghua UniversityBeijing100084China

Climate change significantly impacts human health,exacerbating existing health inequalities and creating new *** study addresses the lack of systematic review in this area by analyzing 2440 publications,focusing on four key terms:health,disparities,environmental factors,and climate *** inclusion criteria limited the selection to English-language,peer-reviewed articles related to climate health hazards,ensuring the relevance and rigor of the synthesized *** process synthesized 65 relevant *** investigation revealed that recent research,predominantly from developed countries,has broadened its scope beyond temperature-related impacts to encompass diverse climate hazards,including droughts,extreme weather,floods,mental health issues,and the intersecting effects of Coronavirus Disease *** has highlighted exposure as the most studied element in the causal chain of climate change-related health inequalities,followed by adaptive capability and inherent *** most significant vulnerabilities were observed among populations with low socioeconomic status,ethnic minorities,and *** study further reveals research biases and methodological limitations,such as the paucity of attention to underdeveloped regions,a narrow focus on non-temperature-related hazards,challenges in attributing climate change effects,and a deficit of large-scale empirical *** findings call for more innovative research approaches and a holistic integration of physical,socio-political,and economic dimensions to enrich climate-health discourse and inform equitable policy-making.

关键词： Climate change health impact Human well-being Inequality Vulnerability

Challenges and perspectives of air pollution control in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 9-16页

作者： Bin Zhao Shuxiao Wang Jiming Hao State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China

Air pollution is one of the most challenging environmental issues in the *** has achieved remarkable success in improving air quality in last decade as a result of aggressive air pollution control ***,the average fine particulate matter(PM2.5)concentration in China is still about six times of the World health Organization(WHO)Global Air Quality Guidelines(AQG)and causing significant human health *** emission reductions of multiple air pollutants are required for China to achieve the *** we identify the major challenges in future air quality improvement and propose corresponding control *** main challenges include the persistently high health risk attributed to PM2.5 pollution,the excessively loose air quality standards,and coordinated control of air pollution,greenhouse gases(GHGs)emissions and emerging *** further improve air quality and protect human health,a health-oriented air pollution control strategy shall be implemented by tightening the air quality standards as well as optimizing emission reduction pathways based on the health risks of various *** the meantime,an“oneatmosphere”concept shall be adopted to strengthen the synergistic control of air pollutants and GHGs and the control of non-combustion sources and emerging pollutants shall be enhanced.

关键词： Air pollution China health impact Air quality standards GHGs Emerging pollutants

Estimating health damage cost from secondary sulfate particles—a case study of Hunan Province,China

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Journal of Environmental Sciences 2003年第5期15卷 611-617页

作者： HAO Ji ming, LI Ji, YE Xue mei, ZHU Tian le (Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China. ) Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

China's coal dominated energy pattern has resulted in large amount of SO 2 emissions. Estimate of the sulfur related health damage cost is necessary to help perform systematic cost benefit analysis and set national energy and emissions control priorities. Current researches were confined to gaseous SO 2 in urban areas; however, secondary sulfate (SO 2- 4) particles can exert serious impact in a wider region. Based on the concept of “intake fraction', CALPUFF long range dispersion model and 180 sample emission sources, multiple regression equation was obtained with good correlation( r =0 85), which illustrates that populations were key parameters to determine intake fraction but source characteristics were insignificant. Based on the formula and the population distribution data, county level intake fractions were mapped for Hunan Province(range: 1 1×10 -6 -3 2×10 -6 ) of China. A combination of county level SO 2 emissions with the intake fractions yields a total 1 98 tons of sulfate(SO 2- 4) inhalation, and resulting total health damage cost to be 0 76(willingness to pay approach, WTP) or 0 16(human capital approach, HC) billion USD in 1997, about 2.1% or 0 45% of GDP in Hunan in 1997. Average health damage cost per ton of SO 2 emission is 930(WTP) or 200 USD(HC). The results demonstrated that more stringent regulation should be forced.

关键词： intake fraction health impact Hunan Province sulfate regression analysis