检索结果-南通市图书馆

Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity:Towards precision medicine in HPV-negative head&neck squamous cell carcinoma

引用

Genes & Diseases 2022年第3期9卷 820-825页

作者： Andrew T.Turk Dario Garcia-Carracedok David T.Kent Elizabeth Philipone Juana Maria Garcia-Pedrero Salvatore M.Caruana Lanny G.Close Gloria H.Su Department of Pathology and cell Biology and Columbia UniversityNew YorkNY 10032USA Department of Otolaryngology Columbia UniversityNew YorkNY 10032USA Department of Otolaryngology Vanderbilt UniversityNashvilleTN 37232USA Department of Otolaryngology Hospital Universitario Central de Asturias and Instituto Universitario de Oncologia Del Principado de AsturiasOviedo 33006Spain

In order to assess Stathmin as an immunohistochemical(IHC)indicator of phosphatidylinositol 3-kinase(PI3K)pathway activity in HPV-negative head&neck squamous cell carcinoma(HNSCC),we compared Stathmin IHC to expression of other pathway *** also evaluated the relationship between Stathmin IHC and the mutational status of four key pathway ***,we ascertained whether Stathmin IHC correlates with tumor grade or primary *** exists between high Stathmin expression and high pAKT1 expression,indicating a role for Stathmin IHC as a marker of pathway *** analysis did not show correlation between Stathmin IHC and mutation of the four genes *** also observed an association between high Stathmin expression and oropharyngeal primary *** results suggest utility of Stathmin IHC as an indicator of PI3K pathway activity,and thereby demonstrate potential relevance of Stathmin IHC in the context,of HNSCC.

关键词： Cancer head&neck squamous cell carcinoma Pathology Stathmin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-risk HPVs, microbiota and epithelial carcinogenesis: state of the art and research contribution of in vitro 3D models

引用

Journal of Cancer Metastasis and Treatment 2019年第11期4卷 1-11页

作者： Diletta Francesca Squarzanti Rita Sorrentino Barbara Azzimonti Laboratory of applied Microbiology Center for Translational Research on Allergic and Autoimmune DiseasesDepartment of Health SciencesMedical SchoolUniversitàdel Piemonte OrientaleNovara 28100Italy Department of Health Sciences Medical SchoolUniversitàdel Piemonte OrientaleNovara 28100Italy Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali Firenze 50121Italy(Local Unit of Universitàdel Piemonte OrientaleNovara 28100Italy

Persistent high-risk human papillomavirus (HR-HPV) infection is associated with anogenital and head & neck squamous epithelial (HNSCC) tumors, which altogether cause about 550,000 new cases every year. Several evidences suggest that the microbiota could have a role on the inflammatory, epithelial mesenchymal transition and tumorigenesis processes promoted by HR-HPV infection, yet the mechanisms involved remain to be clarified. In this review we report the state of the art on this topic and on the most promising in vitro developed models for studying the host-pathogen interactions. Using MEDLINE, several terms were searched and combined to select the most pertinent papers. The investigation was limited to the international indexed articles published in PubMed in the last 10 years. This review reports the latest knowledge in the field of the microbial-associated anogenital tumors and HNSCC. In addition, we also discuss the in vitro epithelial culture systems that reproduce the pathophysiological features of the tumoral microenvironment and the in vivo response to microbial agents, thus representing a useful tool for analyzing at cellular and molecular levels the role played by infective agents in tumorigenesis.

关键词： High risk human papillomavirus microbiota Fusobacterium nucleatum epithelial-mesenchymal transition anogenital cancer head&neck squamous cell carcinoma colorectal cancer transepithelial electrical resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：