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Chinese Science Bulletin 1996年第22期41卷 1881-1885页

作者：鲁云程津培 Department of Chemistry Nankai University Tianjin 300071 China

The reduced form of the nicotinamide-adenine dinucleotide coenzyme(NAD(P)H)plays an important role in many bio-reductions by transferring a hydride ion or an electronto the surrounding substrate(see eq.(1),R represent... 详细信息

关键词： BNAH hantzsch ester reactivity mechanism.

二氧化钛纳米粒子催化合成hantzsch酯和多氢喹啉衍生物(英文)

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催化学报 2012年第9期33卷 1517-1522页

作者： Mahmood TAJBAKHSH Ehsan ALAEE Heshmatollah ALINEZHAD Mohammad KHANIAN Fatemeh JAHANI Samad KHAKSAR Parizad REZAEE Mahgol TAJBAKHSH Department of Organic Chemistry Faculty of ChemistryUniversity of Mazandaran Gorgan Medical University Chemistry Department Islamic Azad University

1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via hantzsch condensation using nanosized titanium dioxide as a heterogeneous *** present methodology offers several advantages such as excellent yields,short reaction times (30-120 min),environmentally benign,and mild reaction *** catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse.

关键词： titanium dioxide nanoparticles hantzsch reaction 1,4-dihydropyridine polyhydroquinoline

二氧化锡纳米粒子催化四组分hantzsch缩合合成多氢喹啉衍生物(英文)

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催化学报 2013年第4期34卷 758-763页

作者： Seyed Mohammad VAHDAT Fereshteh CHEKIN Mehdi HATAMI Maryam KHAVARPOUR Saeed BAGHERY Ziba ROSHAN‐KOUHI Department of Chemistry Science and Research Ayatollah Amoli Branch Islamic Azad University Marine Science Research Institute Khoramshar University of Marine Science and Technology Chemical Engineering Department Islamic Azad University Ayatollah Amoli Branch Department of Chemistry College of Science Bu‐Ali Sina University Young Researchers Club Science and Research Ayatollah Amoli Branch Islamic Azad University

Tin dioxide (SnO2 ) nanoparticles efficiently catalyzed unsymmetrical four-component hantzsch condensations of various aldehydes, dimedone, ethyl acetoacetate, and ammonium acetate to form polyhydroquinoline derivatives in excellent yields. This novel method offers several advantages over the traditional method of synthesizing these compounds, including safety, mild conditions, short reaction times, high yields, and an easy workup.

关键词： Nano tin dioxide catalyst hantzsch condensation Polyhydroquinoline 1 4‐Dihydropyridine

微波辅助溶胶-凝胶法合成MgO纳米粒子及其催化合成hantzsch1,4-二氢吡啶性能(英文)

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催化学报 2012年第9期33卷 1502-1507页

作者： Hakimeh MIRZAEI Abolghasem DAVOODNIA Department of Chemistry Mashhad BranchIslamic Azad University

A microwave-assisted sol-gel method was employed for the preparetion of nano-sized MgO particles using Mg(NO 3)2·6H2O as precursor and deionized water as *** sample calcined at 500℃ had a high specific surface area of 243.2m2/g and particles sizes from *** comparison,MgO nanoparticles were also synthesized without microwave irradiation.X-ray diffraction (XRD) characterization showed the formation of smaller particles after microwave *** structure and morphology of the MgO particles were analyzed by N2 adsorption-desorption,XRD,scanning electron microscopy,and transmission electron *** catalytic behavior was studied with the one-pot synthesis of hantzsch1,4-dihydropyridines from the reaction of aromatic aldehydes,ethyl acetoacetate,and ammonium *** MgO nanoparticles have high catalytic activity and gave the desired products in good to high *** catalyst can be easily recovered by filtration and was used at least three times with only a slight reduction in its catalytic activity.

关键词： magnesium oxide microwave-assisted sol-gel method nanoparticle hantzsch 1,4-dihydropyridine

A Novel Dihydropyridines C-Glycosylated Compound by hantzsch Cyclo-Condensation

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Open Journal of Synthesis Theory and Applications 2018年第2期7卷 17-29页

作者： Soheila Sedaghat Shabnam Madjdpour Chemistry Department Islamic Azad University Tehran North Branch Tehran Iran

The hantzsch synthesis has been used for the preparation of the 1,4-Dihydropyridines compounds with different pharmacophore groups. The use of a designed glycosylated compound in hantzsch synthesis would lead to a novel Dihydropyridines C-Glycosylated compound. We used the 6-methoxy-2, 2-dimethyltetrahydrofuro [3, 4-d] [1, 3] dioxole-4-carbaldehyde as a glycosylated-based aldehydes. The 4-(3,4-Dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxy-lic acid 3-ethyl ester 5-methyl ester was synthesized. The structure of compounds was determined by NMR spectroscopy, FTIR and mass spectroscopy methods. We synthesized this 1,4-Dihydropyridines compound by ionic liquid under ultrasound irradiation as a green chemistry synthesis.

关键词： 1 4-Dihydropyridines c-Glycosylated Multi Component Reaction hantzsch Reaction

Search for New Three-, Four-Component Petasis, Passerini, hantzsch, Kabachnic-Fields, Ugi Reactions with Organic Compounds of Phosphorus, Arsenic, Antimony and Bismuth

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Journal of Chemistry and Chemical Engineering 2014年第4期8卷 428-432页

作者： Aibassov Erkin Zhakenovich Yemelyanova Valentina Stepanovna Shakieva Tatyana Vladimirovna TussupbaevNessipbay Kuandykovich Blagikh Evgeniy Vladimirovich Research Institute of New Chemical Technologies and Materials Kazakh National University AI-Farabi Almaty 005012 Kazakhstan

It is discovered a new three-, four-component Petasis, Passerini, hantzsch, Kabachnic-Fields, Ugi reactions with of arsine, stibine and bismuthine in organometallic chemistry. Modifications were replaced to a nitrogen atom of classical reactions of atoms of phosphorus, arsenic, antimony and bismuth. It has been proposed a new mechanism for possible reactions.

关键词： Petasis Passerini hantzsch Kabachnic-Fields Ugi reactions phosphorus arsenic antimony bismuth.

微波辐射下离子化合物的合成及在hantzsch反应中的应用

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化学试剂 2016年第4期38卷 314-316,322页

作者：裴学海黄克俊陈林艳陈治明贵州师范大学化学与材料科学学院贵州省功能材料化学重点实验室贵州贵阳550001

采用微波合成法得到4种离子化合物,反应在3~6 min内结束,并将4种离子化合物应用于催化hantzsch二氢吡啶及Dilantin的合成,其中[n-C4H9Dmap]Br催化hantzsch二氢吡啶,得到87%的较高收率。离子化合物可反复使用7次,且催化活性并未降低。反... 详细信息

采用微波合成法得到4种离子化合物,反应在3~6 min内结束,并将4种离子化合物应用于催化hantzsch二氢吡啶及Dilantin的合成,其中[n-C4H9Dmap]Br催化hantzsch二氢吡啶,得到87%的较高收率。离子化合物可反复使用7次,且催化活性并未降低。反应具有操作简单、条件温和、产率高等特点。

关键词：微波合成 hantzsch Dilantin 离子化合物

脲酶催化hantzsch反应和碳酸钙仿生构建及其负载酶和药物的研究

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脲酶催化Hantzsch反应和碳酸钙仿生构建及其负载酶和药物的研究

作者：朱淦暨南大学

学位级别：硕士

hantzsch型反应产物—二氢吡啶(1,4-DHP)及其类似物多氢吖啶(PHA)和多氢喹啉(PHQ)是具有药物活性的重要化合物,部分产物已商业化。生物催化剂如酶、DNA等在有机合成中的应用越来越广泛,已受到科学家的极大关注。但脲酶用于催化合成中的... 详细信息

hantzsch型反应产物—二氢吡啶(1,4-DHP)及其类似物多氢吖啶(PHA)和多氢喹啉(PHQ)是具有药物活性的重要化合物,部分产物已商业化。生物催化剂如酶、DNA等在有机合成中的应用越来越广泛,已受到科学家的极大关注。但脲酶用于催化合成中的应用还比较少。生物矿化材料被广泛用于酶的固定,药物负载,新型催化剂的制备等,是材料领域的研究热点之一。本文研究包括以下几个部分:1.以脲酶为催化剂,以原位水解脲得到的氨作为氮源,与芳香醛、达米酮或乙酰乙酸乙酯进行一锅法四组分反应,合成了一系列PHA和PHQ。2.以CMC作为碳酸钙仿生矿化模板,通过控制CMC的浓度,制备了多孔球形球霰石。通过XRD,FTIR,BET,SEM对其形态和结构进行了表征。并探究了多孔碳酸钙在脲酶的负载和药物负载上的应用。结果表明,所得碳酸钙并不能有效负载脲酶,但能有效负载布洛芬并能有效控制其释放。

关键词：脲酶 hantzsch 多氢吖啶多氢喹啉羧甲基纤维素钠碳酸钙球霰石缓释

用hantzsch反应测定制剂中丁胺卡那霉素、卡那霉素、新霉素和妥布霉素

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国外医药.合成药.生化药.制剂分册 1985年第5期 316-317页

作者：钱树德

本文系经hantzsch反应形成双氢卢剔啶(dihydrolutidine)衍生物后,以分光光度法定量测定制剂中丁胺卡那霉素(Ⅰ)、卡那霉素(Ⅱ)、新霉素(Ⅲ)和妥布霉素(Ⅳ)。赋形剂EDTA、苯酚、亚硫酸钠和枸橼酸钠对含量测定均无干扰,而铵盐则有干扰。... 详细信息

本文系经hantzsch反应形成双氢卢剔啶(dihydrolutidine)衍生物后,以分光光度法定量测定制剂中丁胺卡那霉素(Ⅰ)、卡那霉素(Ⅱ)、新霉素(Ⅲ)和妥布霉素(Ⅳ)。赋形剂EDTA、苯酚、亚硫酸钠和枸橼酸钠对含量测定均无干扰,而铵盐则有干扰。Ⅰ、Ⅱ、Ⅲ和Ⅳ的相对标准差(n=7)分别为1.64、1.88、2.10和1.93％。

关键词：丁胺卡那霉素 hantzsch 妥布霉素新霉素抗菌素制剂反应

应用hantzsch反应定量测定药物制剂中丁胺卡那霉素、卡那霉素、新霉素和托普霉素

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国外药学(抗生素分册) 1984年第4期 374-374页

作者：李光华

氨基糖苷类抗生素微生物测定实验误差较高,近来年其它测定方法有所发展。本文介绍基于hantzsch反应,氨基糖苷类抗生素与乙酰丙酮—甲醛溶液形成双氢卢剔啶衍生物,以分光光度法测定。可用本法进行测定的药物有丁胺卡那霉素(注射剂)、卡... 详细信息

氨基糖苷类抗生素微生物测定实验误差较高,近来年其它测定方法有所发展。本文介绍基于hantzsch反应,氨基糖苷类抗生素与乙酰丙酮—甲醛溶液形成双氢卢剔啶衍生物,以分光光度法测定。可用本法进行测定的药物有丁胺卡那霉素(注射剂)、卡那霉素(注射剂和胶囊剂)、新霉素(片剂)以及托普霉素(注射剂)。方法系将待测样品溶液与相应的氨基糖

关键词：丁胺卡那霉素药物托普霉素 hantzsch 定量测定新霉素抗菌素反应