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An Analysis of the Global and Partial Voice handicap Index in Patients with Early Glottic Carcinoma Treated with High Level of Irradiation

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Journal of Cancer Therapy 2014年第1期5卷 21-27页

作者： Daniela Musio Francesca De Felice Cristina Bigelli Nadia Bulzonetti Roberta Guarnaccia Mario Tombolini Giovanni Ruoppolo Marco de Vincentiis Vincenzo Tombolini Dipartimento di Otorinolaringoiatria Audiologia e Foniatria “Giorgio Ferreri” Università degli Studi di Roma “Sapienza” Roma Italy Dipartimento di Scienze Radiologiche Oncologiche e Anatomo-Patologiche Catterdra di Radioterapia Università degli Studi di Roma “Sapienza” Roma Italy

Background: This is a retrospective study on a group of patients with early glottic carcinoma, treated with curative radiotherapy. The aim of the study is to assess voice quality after treatment. We also evaluated local recurrence, overall survival, disease free survival and toxicity. Material and Methods: We examined a total of 36 patients, out of which 27 were smokers: 10 females/5 smokers;26 males/22 smokers. The sample was observed from January 2007 to July 2012 (average follow-up period: 33.5 months, range 12 - 76). Diagnosis of early glottic carcinoma was eight during the two-year period 2007/2008, nine during 2009/2010, eleven during year 2011 and eight during year 2012. All patients suffering from early glottic carcinoma, histopathologically confirmed, were classified as follows: 24 patients T1a, 3 patients T1b, 6 patients T2 and 3 patients had a carcinoma in situ. They were treated only with conventional radiotherapy. After the treatment (total dose 70 Gy), patients were asked to fill out the Voice handicap Index (VHI) questionnaire, composed of 30 questions that covered physical, emotional and functional areas. Results: The global VHI was evidenced with good voice quality (62% of patients: VHI < 30;34% of patients: VHI 31 - 60). Vocal disability was mild in over 70% of patients within the physical area and over 80% within the emotional area. We observed two local recurrences, one occurred five years after the end of radiation therapy and one six months after. In terms of toxicity, we observed that acute reactions, such as dysphonia, dysphagia and erythema, were relatively limited. Conclusions: The VHI index suggests that radiotherapy produces acceptable functional results, with limited repercussion on life quality. In line with literature, our data confirmed good cure rates and larynx preservation (94.4%).

关键词： Glottic Carcinoma Voice handicap Index Radiotherapy

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Preliminary Receiver Operating Characteristic Analysis on Voice handicap Index of Laryngeal Inflammation in Greek Patients

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第3期7卷 115-131页

作者： Dionysios Tafiadis Meropi E. Helidoni Spyridon K. Chronopoulos Evangelia I. Kosma Vasiliki Liagkou Louiza Voniati Nafsika Ziavra George A. Velegrakis Department of Speech & Language Therapy Technological Educational Institute of Epirus Ioannina Greece ENT Department University of Crete Crete Iraklion Greece Department of Informatics and Telecommunications Engineering University of Western Macedonia Kozani Greece Department of Computer Engineering Technological Educational Institute of Epirus Arta Greece Psychologist Private Practice Mihail Aggelou 18 Ioannina Greece Faculty of Medicine School of Health Sciences University of Thessaly Biopolis Larissa Greece Department of Health Sciences Speech and Language Therapy European University Nicosia Cyprus Department of Otolaryngology University of Crete Crete Iraklion Greece

Objective(s): Laryngeal inflammations lead to voice disorders. Medical conditions such as chronic laryngitis, gastroesophageal reflux, laryngopharyngeal reflux, Reinke edema and/or vocal folds hemorrhage, result in diverse symptoms including chronic cough, throat cleaning and dysphonia (e.g. hoarseness). In turn, the dysphonic symptoms can be evaluated via subjective and objective procedures. The objective procedures usually include self-perceived questionnaires like the Voice handicap Index (VHI). Studies reported that VHI can distinguish objectively dysphonic and non-dysphonic populations using the cut-off points of Receiver Operating Characteristic Curves. The purpose of this study was to calculate the cut-off points for individuals exhibiting voice symptoms which had been developed from laryngeal inflammatory diseases in Greece. Methods: One hundred and twelve participants (90 non-dysphonic and 22 dysphonic) filled in the Hellenic Voice handicap Index (VHI) and the Greek translated version of Voice Evaluation Template (VEF) were administrated. All subjects were evaluated by an Otolaryngologist and a Speech-Language Pathologist. Results: The group with voice disorders exhibited higher VHI scores (in total and in its 3 subdomains) compared to non-dysphonic subgroup. Statistical significant differences were found for all VHI’s total cut-off point of 19.50 (sensitivity: 0.882, 1-specificity: 0.011) and for its three subdomains [functional 6.50 (sensitivity = 0.636, and 1-specificity = 0.022);physical 9.50 (sensitivity = 0.636, and 1-specificity = 0.000);emotional 6.50 (sensitivity = 0.455, and 1-specificity = 0.133)]. Conclusion: The preliminary results showed that VHI could discriminate individuals having voice disorders from laryngeal inflammations. The Voice handicap Index can be used as a primary health care tool and a self-monitoring procedure in acute and sub-acute phases of the laryngeal inflammation.

关键词： Receiver Operating Characteristic Statistical Analysis Cut-Off Scores Voice handicap Index Voice Disorders Laryngeal Inflammatory Diseases

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A Preliminary Receiver Operating Characteristic Analysis on Voice handicap Index Results of the Greek Voice-Disordered Patients

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第3期7卷 98-114页

作者： Dionysios Tafiadis Evangelia I. Kosma Spyridon K. Chronopoulos Louiza Voniati Nafsika Ziavra Department of Speech & Language Therapy Technological Educational Institute of Epirus Ioannina Greece Faculty of Medicine School of Health Sciences University of Thessaly Biopolis Larissa Greece Private Practice Mihail Aggelou 18 Ioannina Greece Department of Informatics and Telecommunications Engineering University of Western Macedonia Kozani Greece Department of Computer Engineering Technological Educational Institute of Epirus Arta Greece Department of Health Sciences Speech and Language Therapy European University Nicosia Cyprus

Objective(s): The cutting-edge assessment of voice disorders includes objective and subjective methods in the daily clinical practice. The latter assessment is usually performed through the administration of self-reported questionnaires. Voice handicap Index (VHI) is one of the most widely used tools both in clinical practice and in research level. This tool-questionnaire was employed in this research along with the Voice Evaluation Template (VEF). In turn, the aim of this study was to analyse and produce the cut-off points of VHI for voice-disordered patients in Greece by using Receiver Operating Characteristic Curves (ROC Curves). Methods: Sixty-three participants (40 non-dysphonic and 23 with different types of dysphonia) were classified by ENT (Ear, Nose, and Throat) doctors and SLPs (Speech-Language Pathologists). The Hellenic VHI along with the translated Greek version of the VEF was administered to the subjects of this research. Results: The voice-disordered subjects exhibited higher overall VHI scores (in total and in its 3 subdomains) compared to the control group. Statistical significant differences were found between dysphonic and non-dysphonic participants for all VHI’s construct domains. The cut-off point of VHI total score was estimated at the value of 14.50 (sensitivity: 0.870, 1-specificity: 0.000). Moreover, the cut-off points of the three subdomains were computed as 7.50 for functional (sensitivity: 0.783, 1-specificity: 0.000), 8.50 for physical (sensitivity: 0.739, 1-specificity: 0.000) and 8.50 for emotional domain (sensitivity: 0.783, 1-specificity: 0.050). Conclusion: The preliminary statistical and ROC data analysis of VHI concluded that by using this type of assessment method, populations with or without voice disorders (in Greece) can be distinguished. Albeit this tool is a non-interventional method it could consequently offer an adequate screening and monitoring capability.

关键词： Voice handicap Index Voice Disorders Cut-off Scores Monitoring Preliminary Data

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Column sufficient tensors and tensor complementarity problems

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Frontiers of Mathematics in China 2018年第2期13卷 255-276页

作者： Haibin CHEN Liqun QI Yisheng SONG School of Management Science Qufu Normal University Rizhao 276826 China Department of Applied Mathematics The Hong Kong Polytechnic University Hong KongChina School of Mathematics and Information Science Henan Normal UniversityXinxiang 453007 China

Stimulated by the study of sufficient matrices in linear complementarity problems, we study column sufficient tensors and tensor complementarity problems. Column sufficient tensors constitute a wide range of tensors that include positive semi-definite tensors as special cases. The inheritance property and invariant property of column sufficient tensors are presented. Then, various spectral properties of symmetric column sufficient tensors are given. It is proved that all H-eigenvalues of an even-order symmetric column sufficient tensor are nonnegative, and all its Z-eigenvalues are nonnegative even in the odd order case. After that, a new subclass of column sufficient tensors and the handicap of tensors are defined. We prove that a tensor belongs to the subclass if and only if its handicap is a finite number. Moreover, several optimization models that are equivalent with the handicap of tensors are presented. Finally, as an application of column sufficient tensors, several results on tensor complementarity problems are established.

关键词： Column sufficient tensor H-eigenvalue tensor complementarity problems handicap

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Closed rhinoplasty:effects and changes on voice-a preliminary report

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Plastic and Aesthetic Research 2016年第1期3卷 231-234页

作者： Giuseppe Guarro Romano Maffia Barbara Rasile Carmine Alfano Department of Plastic and Reconstructive Surgery University of Perugia06156 PerugiaItaly

Aim:Effects of rhinoplasty were already studied from many points of view:otherwise poor is scientific production focused on changes of voice after *** preliminary study analyzed objectively and subjectively these potential effects on 19 patients who underwent exclusively closed ***:This preliminary evaluation was conducted from September 2012 to May 2013 and 19 patients have undergone primary rhinoplasty with exclusively closed approach(7 males,12 females).All patients were evaluated before and 6 months after *** of them answered to a questionnaire(Voice handicap Index Score)and the voice was recorded for spectrographic analysis:this system allowed to perform the measurement of the intensity and frequency of vowels(“A”and“E”)and nasal consonants(“N”and“M”)before and after *** were analysed with the Mann-Whitney ***:Sixteen patients showed statistically significant differences after *** was detected in 69%of cases an increased frequency of emission of the consonant sounds(P=0.046),while in 74%of cases the same phenomenon was noticed for vowel sounds(P=0.048).Conclusion:Many patients who undergo rhinoplasty think that the intervention only leads to anatomical changes and improvement of respiratory *** surgeon should instead accurately inform patients about the potential effects on the *** preliminary study reveals the significant effects of closed rhinoplasty on the human voice.

关键词： Rhinoplasty voice handicap score spectrogram

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听力障碍筛查量表用于老年人群听力筛查分析

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听力学及言语疾病杂志 2014年第3期22卷 230-234页

作者：胡娴亭黄治物陈建勇梅玲李蕴任燕唐职健沈敏张勤吴皓上海交通大学医学院附属新华医院耳鼻咽喉头颈外科上海200092 上海交通大学医学院耳科学研究所

目的探讨中文版老年听力障碍筛查量表(the hearing handicap inventory for the elderly-screening version,HHIE-S)用于老年人群听力筛查的可行性及实用性。方法随机选取840例年龄大于60周岁的老年人,先自行填写HHIE-S量表,然后在工作... 详细信息

目的探讨中文版老年听力障碍筛查量表(the hearing handicap inventory for the elderly-screening version,HHIE-S)用于老年人群听力筛查的可行性及实用性。方法随机选取840例年龄大于60周岁的老年人,先自行填写HHIE-S量表,然后在工作人员指导下再次填写,对比指导前后HHIE-S量表的得分,计算指导后量表的信度Cronbach'sα值,判断量表的可行性;所有填表者均进行0.5、1.0、2.0、4.0kHz纯音听阈测试,计算平均纯音听阈(PTA)值,比较筛查目标听力损失分别设定为PTA>25dB HL、PTA>40dB HL、PTA>60dB HL时,HHIE-S得分>8分与>10分及指导前后所填量表的灵敏度、特异度、阳性预测值、假阳性率及假阴性率,并根据ROC曲线及曲线下面积值(AUC),判断三种目标听力损失时量表的实用性。结果 840例老年人指导前后HHIE-S量表平均得分分别为7.6±10.6和10.8±16.7分(P8分作为听力障碍判断标准时较HHIE-S>10分灵敏度高,假阴性率低(P8分时PTA>25dB HL、PTA>40dB HL及PTA>60dB HL三种听力损失条件下ROC曲线下面积值分别为0.70±0.03、0.84±0.01及0.88±0.02。结论适当指导后,HHIE-S量表用于老年人听力筛查得分>8分即可认为存在听力障碍,目标听力损失为PTA>40dB HL时,HHIE-S量表的实用性强,汉化版HHIE-S量表可作为老年人群听力障碍有效的筛查方式。

关键词：老年性聋老年听力障碍筛查量表听力筛查 Hearing handicap inventory for the elderly -screening version (HHIE-S)

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突发性聋伴耳鸣患者治疗前后耳鸣残疾量表和视觉模拟量表比较及相关性

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中国耳鼻咽喉头颈外科 2014年第6期21卷 294-295页

作者：王培邱泽恒陈玲甘小玲余佳莹中山大学孙逸仙纪念医院博济医疗保健中心体检科广东广州510120 中山大学孙逸仙纪念医院耳鼻咽喉科中山大学听力与言语研究所广东广州510120

突发性聋伴耳鸣的发病率较高，多数耳呜患者可伴情绪紧张和疲劳，这成为众多临床医师工作中需要解决的问题。耳呜作为一种主观感受，缺乏客观有效的检测手段。国外应用于评价耳呜的最常用量表主要有耳鸣残疾量表（tinnitus handicap inv... 详细信息

突发性聋伴耳鸣的发病率较高，多数耳呜患者可伴情绪紧张和疲劳，这成为众多临床医师工作中需要解决的问题。耳呜作为一种主观感受，缺乏客观有效的检测手段。国外应用于评价耳呜的最常用量表主要有耳鸣残疾量表（tinnitus handicap inventory，THI）和视觉模拟量表（visual-analoguescale，VAS）。

关键词：听觉丧失突发性(Hearing Loss Sudden) 耳鸣(Tinnitus) 耳鸣残疾量表(tinnitus handicap inventory) 视觉模拟量表(visual—analogue scale)

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