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Journal of Applied Mathematics and Physics 2024年第6期12卷 2007-2019页

作者： Jianping Wang Shenghua Zou Zhicai Guo The Department of Basic Course Education Jian College Jian China

In this article, the transmission dynamics of a hand-foot-mouth disease model with treatment and vaccination interventions are studied. We calculated the basic reproduction number and proved the global stability of disease-free equilibrium when R0 R0 > 1. Meanwhile, we obtained the optimal control strategies minimizing the cost of intervention and minimizing the infected person. We also give some numerical simulations to verify our theoretical results.

关键词： hand-foot-mouth disease Optimal Control Transmission Dynamic Vaccination Interventions

Transmission dynamics of hand-foot-mouth disease with partial immunity through non-integer derivative

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生物数学学报:英文版 2023年第6期16卷 149-173页

作者： Rashid Jan Salah Boulaaras Sultan Alyobit Muhammad Jawad Department of Mathematics University of Swabi Swabi 23561Khyber PakhtunkhwaPakistan Department of Mathematics College of Sciences and Arts Qassim UniversityAr RassSaudi Arabia Department of Mathematics College of Science 8 Arts King Abdulaziz UniversityRabighSaudi Arabia

In this paper,we formulate the transmission phenomena of hand-foot-mouth disease(HFMD)through non-integer *** interrogate the biological meaningful results of the recommended system of *** basic reproduction number is determined through next generation method and the impact of different parameters on the reproduction number is examined with the help of partial rank correlation coeficient(PRCC)*** addition,we concentrated on qualitative analysis and dynamical behavior of HFMD ***'s and Schaefer's fixed-point theorems are used to analyze the uniqueness and existence of the solution of the proposed HFMD *** HFMD system's Ulam-Hyers stability has been confirmed to be *** highlight the impact of the parameters on the dynamics of HFMD,we performed several simulations through numerical scheme to conceptualize the transmission route of the *** be more specific,numerical simulations are used to visualize the effect of input parameters on the systems *** have shown the key input parameters of the system for the control of infection in the society.

关键词： hand-foot-mouth disease fractional derivatives mathematical model threshold parameter numerical scheme dynamical behavior

Antiviral Drugs(Synthetic Small Molecule Inhibitors and Nature Drugs)Against EV71 in Enteroviruses:Advances and Perspectives

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Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 19-33页

作者： Yuwei Liu Yuan Xi Likai Ji Quan Shen Wen Zhang Mengzhu Xue Department of laboratory Medicine Department of Bioinformatics and Intelligent DiagnosisSchool of MedicineJiangsu UniversityZhenjiang 212003JiangsuChina SARI center for stem cell and nanomedicine Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

Background:Enterovirus 71(EV71)is a major virus that causes hand-foot-mouth *** cases of infants and young children,EV71 infection has been associated with severe neurological disease and potentially fatal systemic *** sporadic outbreak worldwide is increasingly prevalent in the Asia-Pacific region,where it has become a major public health ***:No specific antiviral drugs are currently approved for the treatment of EV71 *** purpose of this study is to comprehensively review the research progress of anti-EV71 drugs(synthetic small molecule inhibitors and nature drugs)in the past twenty years,and further to promote the research and development of antiviral drugs against enterovirus ***:This study reviewed the drugs on anti EV71 in the past *** literature search in PubMed database was conducted for original studies and review articles on drugs against enterovirus *** articles published in English were selected for study and ***:As reviewed in this paper,bioactive molecules include receptor analogues,protease inhibitors,natural drugs derived from traditional chinese medicine or natural *** bioactive molecules have shown significant effectiveness in inhibiting the entry and replication of EV71 in vitro and in vivo ***:This review demonstrated that the entry receptor of EV71 into host cells has been studied,and receptor drugs against enterovirus have been made some progress,but most receptor analogues have not been *** research is needed in this area in the *** the other hand,the protease inhibitors have always been a major aspect of anti-enterovirus research and can be developed as antiviral agents for clinical *** terms of natural drugs,many monomers derived from traditional chinese medicine or natural medicine have good antiviral activity and little toxic and side effects on host cells,but in view of their multi-target prop

关键词： hand-foot-mouth disease Enterovirus 71 Receptors Natural drugs Protease inhibitors

Clinical characteristics and treatment of severe encephalitis associated with neurogenic pulmonary edema caused by enterovirus 71 in China

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World Journal of Emergency Medicine 2010年第2期1卷 108-113页

作者： Yu-cai Zhang Xing-wang Li Xiao-dong Zhu Su-yun Qian Yun-xiao Shang Bi-ru Li Xiao-lin Liu Children's Hospital Shanghai Jiaotong University Shanghai 200040 China Beijing Ditan Hospital Beijing 100010 China Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 China Beijing Children's Hospital Beijing 100045 China Shengjing Hospital China Medical University Shenyang 110004 China Children Medical Center Shanghai Jiaotong University School of MedicineShanghai 200127 China People's Hospital of Fuyang City Fuyang 236004 China

BACKGROUND:hand-foot-mouth disease has become a major public health issue in children in China. In the present prospective study we investigated the clinical characteristics and emergency management of children with severe encephalitis associated with NPE caused by enterovirus 71.;METHODS:The study was conducted in 2 pediatric intensive care units (PICUs) over a 2-month period. Clinical records were reviewed of critically ill children with severe encephalitis associated with NPE caused by EV71 who were admitted to PICUs during the period of May to June 2008 in Fuyang.;RESULTS:We reviewed the complete records of 36 children, of whom 23 (63.9%) were male and 13 (36.1%) female. Their age ranged from 4 to 48 months, with an average of 15.8 months. All children except one were under 3 years of age. The overall mortality in these children was 19.4%. The average duration of critical life threatening signs and symptoms was 2.1 days (12 hours-5 days). Nervous system diseases included brainstem encephalitis in 27 children (75%), brainstem encephalitis associated with myelitis in 6 children (16.7%), and general encephalitis in 3 chidren (8.3%), respectively. In 12 patients of NPE (33.3%) pink or bloody bubble sputum and asymmetric pulmonary edema or hemorrhage was the primary manifestation but no typical exanthema was observed. Five children died of acute onset of NPE and / or pulmonary hemorrhage with rapid progression of cardiopulmonary failure within hours after admission. Therapeutic management consisted of mechanical ventilation and administration of mannitol, methylprednisolone, intravenous immunoglobulin (IVIG) and vasoactive drugs, associated with the need of fluid volume resuscitation in 9 (25%) of the 36 children.;CONCLUSIONS:In children less than 3 years of age found to be affected by severe EV71 encephalitis associated with NPE, one fifth may die. The major organ systems infected by severe EV71 include the central nervous system, the respiratory system, and the car

关键词： Child Encephalitis Enterovirus71 (EV71) hand-foot-mouth disease Neurogenic pulmonary edema