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Depression and sarcopenia-related traits:A Mendelian randomization study

World Journal of Psychiatry 2023年第11期13卷 929-936页

作者： Ding-Kun Wang Yi-Hao Li Xiao-Ming Guo Department of Neurosurgery Tongde Hospital of Zhejiang ProvinceHangzhou 310016Zhejiang ProvinceChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310012Zhejiang ProvinceChina

BACKGROUND Observational studies have suggested that depression is associated with ***,the causal relationship between depression and sarcopenia remains *** To investigate the causal relationship between depression and *** We performed a Mendelian randomization(MR)analysis to identify the bidirectional relationship between depression and sarcopenia-related *** data and independent variants used as instrumental variables came from large genome-wide association studies of depression(414055 cases and 892299 controls),of appendicular lean mass(ALM,450243 participants),and of hand grip strength(exposure:360000 participants;outcome:334925 participants).RESULTS We identified a negative association of depression with lower ALM[odds ratio(OR):0.932,95%confidence interval(95%CI):0.889-0.979,P=0.005].In the reverse MR analysis,we also observed an inverse association of hand grip strength with depression(OR:0.200,95%CI:0.108-0.370,Pstrength might lead to a higher risk of depression.

关键词： Appendicular lean mass Depression hand grip strength Mendelian randomization Older adults Sarcopenia

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Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 44-54页

作者： Suprabhat Giri Prajna Anirvan Sumaswi Angadi Ankita Singh Anurag Lavekar Department of Gastroenterology and Hepatology Kalinga Institute of Medical SciencesBhubaneswar 751024OdishaIndia Department of Gastroenterology Kalinga Gastroenterology FoundationCuttack753001OdishaIndia Department of Gastroenterology Nizam’s Institute of Medical SciencesHyderabad 500082TelanganaIndia Department of Gastroenterology Seth GS Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sagar HospitalBengaluru 560041KarnatakaIndia

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced ***,characterized by decreased muscle strength and mass,shares common pathophysiological traits with *** association exists between sarcopenia and increased NAFLD ***,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain *** To analyze the prevalence and outcomes of sarcopenia in patients with *** We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June *** included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse *** also used the Newcastle-Ottawa scale for quality *** Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for *** was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such *** in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and *** This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD *** variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent *** review demonstrates the multidimension

关键词： Non-alcoholic fatty liver disease Sarcopenia Hepatic fibrosis Low muscle mass hand grip strength Bioelectric impedance analysis Dual X-ray absorptiometry

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