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Towards greener and more sustainable cellulose-based hand sanitizer products

Journal of Bioresources and Bioproducts 2017年第2期2卷 50-54页

作者： Bo Sun Min Zhang Zhibin He Linqiang Zheng Jing Shen Yonghao Ni Key Laboratory of Food Nutrition and Safety(Tianjin University of Science and Technology) Ministry of EducationTianjin 300457China Department of Chemical Engineering University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Key Laboratory of Bio-based Material Science and Technology of Ministry of Education Northeast Forestry UniversityHarbin 150040China Tianjin Food Safety&Low Carbon Manufacturing Collaborative Innovation Center Tianjin300457China

More than 85%of the currently marketed hand sanitizer products are alcohol-based products,and the alcohol content is usually about 70%in order to be *** high alcohol content can cause dehydration,which is undesirable for sensitive skin,particularly for *** creates opportunities for the development of innovative hand sanitizer products that are free of alcohol and have green nano-cellulose-based materials as carriers for the antibacterial *** skin affinity and biocompatibility are the special features of the newly developed products,which would satisfy the need of the general public for green products.

关键词： hand sanitizer Alcohol-free Nano-cellulose-based Products Biocompatibility

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Effects of some common additives on the antimicrobial activities of alcohol-based hand sanitizers

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 222-226页

作者： Nzekwe Ifeanyi Thaddeus Egbuna Chukwuemeka Francis Okpara Ogonna Jane Agubata Chukwuma Obumneme Esimone Charles Okechukwu Department of Pharmaceutics & Pharmaceutical Technology Nnamdi Azikiwe University Department of Pharmaceutical Technology & Industrial Pharmacy University of Nigeria Department of Pharmaceutical Microbiology and Biotechnology Nnamdi Azikiwe University

Objective: To study the effects of some common additives on the antimicrobial activities of alcohol-based hand sanitizers. Methods: The antibacterial activities of varying aqueous concentrations of ethanol and isopropyl alcohol were tested by the agar well diffusion method. The influences of different concentrations of glycerin was similarly tested. Finally, isopropyl alcohol and benzalkonium chloride were combined in different ratios within the sate use concentrations of each, and the effects of these combinations were compared with values obtained for the two agents used alone. Statistical methods, such as student t test and one-way ANOVA were used when appropriate to evaluate the differences in activity. Results: The activities of the alcohols showed marked concentration dependence, and both showed peak activity at 85%-95% concentration range. Over the concentration range of 60%-100%, isopropyl alcohol inhibited more bacterial and fungal organisms than ethanol, though the inhibition zone diameters it produced were not statistically different from those of ethanol for organisms which were sensitive to both of *** of glycerin reduced the antimicrobial activities of the isopropyl alcohol, as shown by reduction in the inhibition zone diameters produced in vitro, which may be due to reduced drug diffusion with increase in viscosity. Addition of benzalkonium to isopropyl alcohol systems improved the activity of the alcohol, but the overall activity of the combination was not superior to that seen in the use of benzalkonium alone. Conclusion: Alcohol-based hand sanitizers should not be used outside the concentration range of 85%-95% and isopropyl alcohol inhibits more bacterial and fungal organisms than ethanol for most concentrations. Inclusion of benzalkonium improves the antimicrobial spectrum and activity of isopropyl alcohol, and the combination may justifiably be used to achieve both immediate and long lasting effect. Glycerin may adversely affect the an

关键词： Infection control Disinfection hand sanitizer Alcohol Optimization

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Evaluation of the Quality and Safety of hand sanitizers Marketed in Saudi Arabia

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Health 2022年第5期14卷 523-534页

作者： Ibrahim A. Al Othaim Turki F. Al-Mutari Nasser S. Bakiri Khalid M. Bin Shehail Fouza K. Al-Enazi Fahad S. Aldawsari Anwar S. Al Suhaibani Yahya M. Alshehri Reference Laboratory for Medicine and Cosmetics Saudi Food and Drug Authority (SFDA) Riyadh Saudi Arabia National Drug and Cosmetic Control Laboratories Saudi Food and Drug Authority (SFDA) Riyadh Saudi Arabia

Background: hand sanitizers are an important preventive measure to halt the spread of pathogens, which has become a huge demand during the coronavirus disease (COVID-19). Consequently, their safety and quality are top priorities for regulatory organizations. Methods: Saudi Food & Drug Authority laboratories have analyzed numerous samples of hand sanitizers in order to ensure their safety and efficacy. Active ingredients, as well as hazardous impurities, have been checked according to the pharmacopeia. Results: In this study, we report the results of the analysis of 1409 samples, which represent the majority of products available in the Saudi Arabian market. The results showed that 196 samples (13.9%) did not meet international standards. Specifically, out of 196 failed samples, 75, 12, and 4 products contained hazardous substances such as methanol, 1-propanol, and acetaldehyde, respectively. Additionally, some failed samples contained foreign particles, were improperly labeled, or contained an inadequate concentration of alcohol. Conclusion: The substandard hand sanitizers possess a risk to the community, particularly during pandemics, and hence stringent yet dynamic regulations should be implemented.

关键词： hand sanitizer COVID-19 US FDA Ethanol Methanol

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Study on Bacteriostatic Properties of Piroctone Olamine in Commonly Used Surfactants Systems

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China Detergent & Cosmetics 2023年第1期8卷 45-51页

作者： Lei Faling Xiao Lei Infinitus(China)Co. Ltd.China

Piroctone olamine(OCT) was used as the main bacteriostatic component, the inhibition of OCT in different kinds and mass concentrations of surfactants were studied. Six surfactants commonly used in personal care products, i.e. sodium laureth sulfate(AES), cocamidopropyl betaine(CAB 35), sodium lauroyl sarcosinate(LS-30), sodium lauroyl glutamate(ULS-30S), alkyl glycoside(APG), cocamide methyl MEA(CMMEA),were used. The results showed that the bacteriostatic of OCT decreased with the increase of AES, which was suggested ≤ 5%. OCT has good bacteriostatic performance in the systems of amino acid surfactants and high dosage of amphoteric surfactants, 5% LS 30 and ≥ 10% CAB 35 was recommended. High dosage of nonionic surfactant could interfere the bacteriostatic performance of OCT, the recommended dosage was ≤ 2%.In addition, OCT has good bacteriostatic performance against Staphylococcus aureus, Escherichia coli and Candida albicans when pH was controlled less than 5.5.

关键词： piroctone olamine surfactant bacteriostatic hand sanitizer

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