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Recombinant Human Prolactin Protects against Irradiation-Induced Myelosuppression

Cellular & Molecular Immunology 2005年第5期2卷 379-385页

作者： Weici Zhang Rui Sun Jianhua Zhang Jian Zhang Zhigang Tian Institute of Immunopharmacology and Immunotherapy Shandong University 44 Wenhua West Road Jinan 250021 China Institute of Basic Medical Sciences Shandong Academy of Medical Sciences Jinan 250062 China

Prolactin is a multifunctional hormone that exerts many separate functions and acts as an important connection between the endocrine and immune systems. There are increasing researches implicating the role of prolactin in hematopoiesis. Enhanced erythropoiesis in pregnant women and direct erythropoietic effects in vitro of plasma either from pregnant or lactating mice have been reported. Furthermore, regression of erythroblastic leukemia has been observed in a significant number of rats after hypophysectomy. In this study, the effects of recombinant human prolactin （rhPRL） on hematopoiesis were assessed in irradiated mice. Mice were treated with rhPRL for five consecutive days after exposure to a lethal dose or a sub-dose irradiation. Prolonged survival rate and increased erythropoiesis were observed in the irradiation-induced myelosuppressive mice. It was concluded that rhPRL might act on erythropoiesis and could be a potential candidate for the treatment of irradiation-induced myelosuppresion in clinic.

关键词： prolactin irradiation erythropoiesis erythroid cell haematocrit

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Effects of sodium valproate combined with levetiracetam in treatment of children epilepsy and its influences on serum S-100βand high mobility group box-1

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Discussion of Clinical Cases 2020年第1期7卷 12-18页

作者： Huimin Li Jinli Hao Hua Chen Yong Meng Department of Pediatrics Baogang HospitalBaotouInner MongoliaChina Department of Pediatrics Surgery the First Affiliated Hospital of Xinxiang Medical CollegeHenan ProvinceChina

Objective:To explore the effects of sodium valproate combined with levetiracetam in the treatment of children epilepsy,and its influences on serum S-100βand high mobility group box-1(HMGB-1)in children with ***:A total of 160 children who were diagnosed as epilepsy in Baogang Hospital of Inner Mongolia from July 2016 to October 2018 were selected as research *** were randomly divided into the study group(n=80)and the control group(n=80)by the random number table method,i.e.,they were treated with sodium valproate combined with levetiracetam and sodium valproate alone,*** 16 weeks of treatment,the effective rates of epileptic seizure treatment and the improvement of epileptiform discharge were evaluated,and chi-square test was used for statistical *** related indicators,including serum tumor necrosis factor-(TNF-α),hypersensitive C-reactive protein(hs-CRP),homocysteine(Hcy),haematocrit(HCT),erythrocyte sedimentation rate(ESR),serum S-100βand HMGB-1,were measured before and after *** t-test was used for the comparison in the above indicators within a group before and after treatment;group t-test was used for the comparison between two ***-square test was used for the comparison in the rate of adverse reactions during treatment between two *** study was approved by Ethics Committee of Baogang Hospital(Approval No.:BG201606073),and all children’s guardians were required to sign informed consent forms for clinical *** were no statistically significant differences between two groups in general clinical data(p>0.05),such as sex constituent ratio,age,the course of disease,the frequency of epileptic seizure per year before treatment,the incidence of epileptiform discharge before treatment and the constituent ratio of types of epileptic seizure,***:1)After treatment,the effective rates of epileptic seizure treatment and the improvement of epileptiform discharge in the study group were 9

关键词： Epilepsy Sodium valproate Levetiracetam S-100 HMGB-1 protein Tumor necrosis factor- haematocrit Children

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肺脏疾病患者血流变与临床生化指标观察

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中国血液流变学杂志 1996年第3期6卷 72-73,67页

作者：朱心智秦任甲蓝佳庭卢权昌李友邕易菲黄作群杨霞芳唐萍李乃珍广西南宁市二轻局职工医院 530011 桂林医学院南宁市第一人民医院广西区人民医院

在肺脏疾病的发生及发展过程中，患者血液流变性可出现异常．本文对６２例肺脏疾病患者的血液流变及临床生物化学指标检测结果进行对比，表明血液流变指标的改变与生物化指标明显相关，现将结果报告如关．

关键词： pulmonary diseases hemorheology blood viscosity blood gas analysis haematocrit

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