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hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain

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Protein & Cell 2011年第6期2卷 470-476页

作者： Jiwei Ding Lishan Su Guangxia Gao Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100039China The University of North Carolina Chapel HillNC 27599-7295USA

Hepatocyte growth factor-regulated tyrosine kinase substrate(hrs)is a key component of the endosomal sorting complexes required for transport and has been demonstrated to play a regulatory role in endocytosis/exocytosis and the accumulation of internal vesicles in multivesicular bodies.Citron kinase is a Ser/The kinase that we previously reported to enhance human immunodeficiency virus type 1(HIV-1)virion production.However,the relationship between hrs and citron kinase in HIV-1 production remains elusive.Here,we report that hrs interacts with citron kinase via its FYVE domain.Overexpression of hrs or the FYVE domain resulted in a significant decrease in HIV-1 virion production.Depletion of hrs by RNA interference in HEK293T cells increased HIV-1 virion production and enhanced the activity of citron kinase.These data suggest that hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.

关键词： citron kinase hrs HIV-1 budding

Management of Hepatorenal Syndrome:A Review

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 192-199页

作者： Raseen Tariq Ashwani K.Singal Department of Medicine Rochester General HospitalRochesterNYUSA Division of Gastroenterology and Hepatology University of South DakotaSanford School of MedicineSioux FallsSDUSA

Acute kidney injury (AKI) occurs frequently in patients with cirrhosis, and hepatorenal syndrome (hrs) is second most common etiology of AKI after volume responsible pre-renal etiology. AKI in these patients negatively impacts pre- and post-transplant patient survival and healthcare burden. Re-duced effective blood volume with consequent reduced renal blood flow, along with systemic inflammation in patients with decompensated cirrhosis, result in susceptibility to hrs. In this article, we will review updates over the last 5 years on the changing definition with diagnostic criteria and nomenclature of AKI and hrs, data on medical treatment with vasocon-strictors, and urinary biomarkers in diagnosis of etiology of AKI. We will also discuss the significance of liver trans-plantation evaluation once the diagnosis of hrs is established and the post-transplant immunosuppression management. We will also review one of the challenging issues that remains among transplant-eligible patients, that of allocation of si-multaneous liver kidney transplant. Finally, we will review the new implemented policy from the Organ Procurement Trans-plant Network on simultaneous liver kidney allocation.

关键词： hrs Management Liver transplant for hrs

Tunneling Anisotropic Magnetoresistance in L1_0-MnGa Based Antiferromagnetic Perpendicular Tunnel Junction

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Chinese Physics Letters 2018年第8期35卷 88-92页

作者：赵旭鹏魏大海鲁军毛思玮余之峰赵建华 State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of Sciences College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences

We report on the tunneling anisotropic magnetoresistance in antiferromagnetic perpendicular tunnel junction consisting of L10-MnGa/FeMn/AlOx/Pt grown on GaAs（001） substrates by molecular-beam epitaxy. The temperature-dependent perpendicular exchange bias effect reveals an exchange coupling between ferromagnetic L10-MnGa and antiferromagnetic FeMn. The rotation of antiferromagnetic spins in FeMn can be driven by perpendicularly magnetized L10-MnGa due to the exchange-spring effect at the interface and leads to roomtemperature tunneling anisotropic magnetoresistance ratio of 0.86%. We also find that the tunneling anisotropic magnetoresistance strongly depends on temperature and angle. These results have broadened the material selection range for high performance antiferromagnetic spintronic devices.

关键词： AFM LRS hrs As Pt Ga

Nonvolatile Resistive Switching and Physical Mechanism in LaCrO3 Thin Films

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Chinese Physics Letters 2018年第4期35卷 98-102页

作者：胡万景胡令魏仁怀汤现武宋文海戴建明朱雪斌孙玉平 Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 University of Science and Technology of China Hefei 230026 High Magnetic Field Laboratory Chinese Academy of Sciences Hefei 230031 Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093

Polycrystalline LaCrO3（LCO） thin films are deposited on Pt/Ti/SiO2/Si substrates by pulsed laser deposition and used as the switching material to construct resistive random access memory devices. The unipolar resistive switching（RS） behavior in the Au/LCO/Pt devices exhibits a high resistance ratio of ~104 between the high resistance state（hrs） and low resistance state（LRS） and exhibits excellent endurance/retention characteristics.The conduction mechanism of the hrs in the high voltage range is dominated by the Schottky emission, while the Ohmic conduction dictates the LRS and the low voltage range of hrs. The RS behavior in the Au/LCO/Pt devices can be understood by the formation and rupture of conducting filaments consisting of oxygen vacancies,which is validated by the temperature dependence of resistance and x-ray photoelectron spectroscopy results.Further analysis shows that the reset current IR and reset power PR in the reset processes exhibit a scaling law with the resistance in LRS（R0）, which indicates that the Joule heating effect plays an essential role in the RS behavior of the Au/LCO/Pt devices.

关键词： La Cr hrs LRS Pt Nonvolatile Resistive Switching and Physical Mechanism in LaCrO3 Thin Films

Bipolar Resistive Switching in Epitaxial Mn_3O_4 Thin Films on Nb-Doped SrTiO_3 Substrates

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Chinese Physics Letters 2016年第6期33卷 112-115页

作者：来旭波王宇航石晓兰李东勇刘伯旸王荣明张留碗 Department of Physics Beijing University of Aeronautics and Astronautics National Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid PhysicsChinese Academy of Engineering Physics State Key Laboratory of Low-Dimensional Quantum Physics Collaborative Innovation Center of Quantum MatterDepartment of PhysicsTsinghua University

Spinel （O01）-orientated Mn304 thin films on Nb-doped SrTi03 （001） substrates are fabricated via the pulsed laser deposition method. X-ray diffraction and high-resolution transmission electron microscopy indicate that the as-prepared epitaxial fihn is well crystaiHzed. In the film plane the orientation relationship between the film and the substrate is [lOOjMn3 04 ｜｜[110] Nb-doped SrTiO3. After an electroforming process, the film shows bipolar nonvolatile resistance switching behavior. The positive voltage bias drives the sample into a low resistance state, while the negative voltage switches it back to a high resistance state. The switching polarity is different from the previous studies. The complex impedance measurement suggests that the resistance switching behavior is of filament type. Due to the performance reproducibility and state stability, Mn3O4 might be a promising candidate for the resistive random access memory devices.

关键词： hrs is of LRS in Bipolar Resistive Switching in Epitaxial Mn3O4 Thin Films on Nb-Doped SrTiO3 Substrates on Mn

Simulation of stray grain formation in Ni-base single crystal turbine blades fabricated by hrs and LMC techniques

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China Foundry 2017年第2期14卷 75-79页

作者： Ya-feng Li Lin Liu Tai-wen Huang Miao Huo Jun-sheng He Jun Zhang Heng-zhi Fu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

The simulation models of the thermal and macrostructural evolutions during directional solidification of Ni-base single crystal(SX) turbine blades under high rate solidification(hrs) and liquid metal cooling(LMC) have been constructed using Pro CAST software, coupled with a 3D Cellular Automaton Finite Element(CAFE) model. The models were used to investigate the tendencies of stray grain(SG) formation in the platform region of turbine blades fabricated by hrs and LMC techniques. The results reveal that the LMC technique can prohibit SG formation by smoothing the concaved isotherm and in turn alleviating the undercooling in the platform ends to let the dendrites fill up the undercooled zone before SG nucleation. The simulation results agreed well with the experimental results, indicating that these models could be used to analyze the macrostructural evolution or to optimize process parameters to suppress SG formation. Using these models, the critical withdrawal rate for casting SX turbine blades without SG formation were determined to be around 75 μm·s^(-1) and 100 μm·s^(-1) for hrs and LMC respectively, suggesting that LMC can be used as an efficient technique in fabricating SX turbine blades without any SG defect formation.

关键词：热侧面 macrostructural 进化模拟 hrs LMC 迷路的谷物 TG146.1+5 A

考虑定向参数精度信息的TerraSAR-X和SPOT-5hrs影像RFM联合定位

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测绘学报 2017年第2期46卷 179-187页

作者：程春泉张继贤黄国满张力杨景辉中国测绘科学研究院北京100830

卫星影像的RFM模型具有传感器无关的优点,适用于多源影像的几何定位处理,但在无地面控制点条件下联合定位时存在自主定位优势影像难以发挥主导作用且求解易发散的不足。本文通过将影像的先验自主定位精度和成像线性漂移转化为像方定向... 详细信息

卫星影像的RFM模型具有传感器无关的优点,适用于多源影像的几何定位处理,但在无地面控制点条件下联合定位时存在自主定位优势影像难以发挥主导作用且求解易发散的不足。本文通过将影像的先验自主定位精度和成像线性漂移转化为像方定向参数的精度和权信息,建立考虑影像定向参数精度信息的RFM模型。以12景TerraSAR-X和6对12景覆盖面积约为18万km2的SPOT-5hrs立体长条带影像为数据源,对两类影像定向参数先验精度配置偏差、SAR影像升降轨道方向、SAR影像数目、SAR影像分布等因素对定位精度的影响进行了系列定位试验,少量SAR与大范围hrs联合的影像自主定位平面/高程精度可达6.0m/4.2m。本文RFM平差模型无地面控制点定位精度和定向参数求解稳健性相对于传统模型有显著提升,是卫星影像无控制点1∶10万/1∶5万全球测图的一种潜在方法。

关键词： RFM 无控制点定位异源影像 TerraSAR-X SPOT-5 hrs 全球测图

聚集效应对银纳米粒子的二阶非线性光学特性的影响研究

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物理学报 2005年第1期54卷 144-148页

作者：王刚端木云崔一平张宇刘宓东南大学电子工程系南京210096 东南大学生物科学与医学工程系分子与生物分子电子学教育部重点实验室南京210096

运用超瑞利散射 (hrs)技术 ,对由KNO3诱导聚集的银纳米粒子的二阶光学非线性特性进行了实验研究 .通过粒子尺寸测量和透射电镜观察 ,表明银纳米粒子的聚集方式为链状聚集 .当聚集体平均尺寸为 12 0nm时 ,银纳米粒子聚集体的hrs信号强度... 详细信息

运用超瑞利散射 (hrs)技术 ,对由KNO3诱导聚集的银纳米粒子的二阶光学非线性特性进行了实验研究 .通过粒子尺寸测量和透射电镜观察 ,表明银纳米粒子的聚集方式为链状聚集 .当聚集体平均尺寸为 12 0nm时 ,银纳米粒子聚集体的hrs信号强度比聚集前增大了约 15倍 .分析表明 ,聚集导致银纳米粒子表面电场极化强度的增强和极化分布的改变。

关键词：银纳米粒子二阶非线性光学光学非线性聚集体表面平均电场 hrs 改变诱导

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Hepatorenal syndrome

World Journal of Gastroenterology 2007年第30期13卷 4046-4055页

作者： Sharon Turban Paul J Thuluvath Mohamed G Atta Department of Medicine Division of Nephrology Johns Hopkins School of Medicine and the Johns Hopkins Hospital Baltimore Maryland United States Department of Medicine Division of Gastroenterology Johns Hopkins School of Medicine and the Johns Hopkins Hospital Baltimore Maryland United States

Hepatorenal syndrome (hrs) is a "functional" and reversible form of renal failure that occurs in patients with advanced chronic liver disease. The distinctive hallmark feature of hrs is the intense renal vasoconstriction caused by interactions between systemic and portal hemodynamics. This results in activation of vasoconstrictors and suppression of vasodilators in the renal circulation. Epidemiology, pathophysiology, as well as current and emerging therapies of hrs are discussed in this review.

关键词：急性肾衰竭肝疾病 hrs 治疗方法