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TLR9 Expression and Its Role in Chemosensitivity to DDP in Human Cervical Cancer Cells in vitro

Journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第4期31卷 550-554页

作者：翁艳洁王永军石英周文娟王鸿雁王常玉 Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Minimally Invasive Center of Gynecology Beijing Obstetrics and Gynecology HospitalCapital Medical University

Inflammation and infection play an important role in the pathogenesis of many ***-like receptors（TLRs） are a class of pattern recognition receptors that recognize conserved components of microbes and trigger the immune response against invading ***-like receptor 9（TLR9） recognizes non-methylated cytosine-phosphateguanosine（CpG） DNA sequences which are the surrogate for viral ***9 may react to tumor development and progression during chronic inflammation that involves the tumor *** order to study the role of TLR9 in cervical cancer,we analyzed the TLR9 expression in different types of hpv infection cervical cancer *** we detected if CpG sequences influenced the TLR9 expression and the sensitivity to cisplatin（DDP） of these cervical cancer cells in *** expression of TLR9 mRNA and protein in SiHa,Hela and C33A cells was detected by RT-PCR and Western ***-time PCR was used to examine the TLR9 expression changes induced by *** of the cervical cancer cells to cisplatin（DDP） was measured by *** was observed that the expression of TLR9 mRNA and protein was increased gradually in SiHa（hpv16＋）,Hela（hpv18＋） and C33A（hpv-） *** doses of CpG increased the TLR9 expression only in C33A（hpv-） cells,but not in SiHa（hpv16＋） and Hela（hpv18＋） ***,low dose of CpG significantly increased the sensitivity of C33A（hpv-） cells,but not that of SiHa（hpv16＋） and Hela（hpv18＋） *** results indicated that TLR9 may serve as a protective agent in hpv negative cervical cancer *** was concluded that TLR9 could improve the sensitivity to DDP in hpv negative cervical cancer cells and might represent a potential therapeutic option in clinical practice.

关键词： cervical cancer Toll-like receptor 9 cisplatin hpv infection

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Role of human papillomavirus and cell cycle-related variants in squamous cell carcinoma of the oropharynx

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The Journal of Biomedical Research 2010年第5期24卷 339-346页

作者： Guojun Li Zhigang Huang Xingming Chen Qingyi Wei Department of Head and Neck Surgery The University of Texas M.D.Anderson Cancer CenterHoustonTexas 77030-4095USA Department of Epidemiology The University of Texas M.D.Anderson Cancer CenterHoustonTexas 77030-4095USA Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityKey Laboratory of O tolaryngology Head and Neck SurgeryMinistry of EducationBeijing Institute of OtolaryngologyBeijing 100730China Department of Otolaryngology Head and Neck Surgery Peking Union Medical College HospitalPeking Union Medical Collegea nd Chinese Academy of Medical SciencesBeijing 100005China.

SCCOP is a subset of squamous cell carcinoma of the head and neck and is characterized by aggressive local tumor growth that requires morbid local-regional therapies. It has a moderately high recurrence rate, common medical comorbidities, and a high frequency of second primary tumorst^a. It is estimated that in the USA approximately 9,000 new cases of SCCOP were diagnosed and 2,110 deaths would result from these cancers in 2006. The median age at diagnosis is approximately 60 y, and this disease occurs more frequently in men （-75%） than in womenta.

关键词： P53 CODON-72 POLYMORPHISM CERVICAL-CANCER P16 PROTEIN TONSILLAR CARCINOMAS SEXUAL-BEHAVIOR GENE-EXPRESSION PHYSICAL STATUS hpv infection NEVER-SMOKERS NECK CANCERS

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Journal of Cancer Therapy 2016年第12期7卷 901-907页

作者： Anita Agrawal Rajni Chibbar Anahita Safavi-Naini Division of Gynecologic Oncology Saskatoon Cancer Centre University of Saskatchewan Saskatoon Canada Department of Pathology and Laboratory Medicine Saskatoon Health Region University of Saskatchewan Saskatoon Canada Medical College University of Western Ontario London Canada

Objective: To describe the primary carcinoma of the retroperitoneum that was positive for human papillomavirus (hpv), a surrogate molecular marker for high-risk hpv (p16) and p53. Methods: This is a case report. Results: We report a case of 50-year-old woman with a large retroperitoneal mass (squamous cell carcinoma on histology) that was treated in September of 2014 with radical concurrent chemotherapy with weekly cisplatin and pelvic radiation (4500 cGY) and additional right pelvic boost of 900 cGY. It was assumed she had FIGO stage IIIB local advanced cervical cancer. She initially presented with the right leg swelling, severe pain and difficulty in walking and was treated with antibiotics for presumed cellulitis. Several months later right leg extensive deep vein thrombosis (DVT) was diagnosed and was started on anticoagulation. CT scan and MRI reported a large right-sided retroperitoneal mass occluding the illiac vessels and ureter. The mass had invaded into the adjacent pelvic sidewall, with destruction of the iliacus muscle and underlying iliac wing. MRI showed that the cervix and uterus were both normal. On examination cervix appeared grossly normal and cervical punch biopsy revealed HSIL only. CT-guided biopsy of the mass revealed a moderately differentiated squamous cell carcinoma positive for p16 and p53. Conclusion: Primary squamous cell carcinoma of the retroperitoneum is a real entity that is unknown. It is unclear if primary neoplasia in the cervix was small from which a cell clone arose and migrated to the retroperitoneal space.

关键词： Primary Retroperitoneal Squamous Cell Carcinoma hpv infection Cervical Neoplasia

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Traditional Chinese medicine for human papillomavirus(hpv) infections:A systematic review

Traditional Chinese medicine for human papillomavirus(HPV) i...

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第9届中国中西医结合学会妇产科专业委员会第二次学术会议

作者： Jing Lin Lanting Chen Xuemin Qiu Na Zhang Qiting Guo Yan Wang Mingyan Wang Hans-Jürgen Gober Wei Tang Dajin Li Ling Wang Laboratory for Reproductive Immunology Hospital & Institute of Obstetrics and Gynecology IBS Shanghai Medical College Fudan University Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases The Academy of Integrative Medicine of Fudan University Public Health of Zhejiang University Department of Pharmacy Kepler University ClinicNeuromed Campus Department of Surgery Graduate School of Medicine the University of Tokyo

人乳头瘤病毒的感染通常无害而又常见,持续感染却会带来癌症、生殖器疣等健康问题。对于未感染人群,疫苗能提供安全有效的保护,但是疫苗价格昂贵而且覆盖的病毒种类有限。对于感染者,迄今已有若干治疗人乳头瘤病毒相关的良性或恶性疾病... 详细信息

人乳头瘤病毒的感染通常无害而又常见,持续感染却会带来癌症、生殖器疣等健康问题。对于未感染人群,疫苗能提供安全有效的保护,但是疫苗价格昂贵而且覆盖的病毒种类有限。对于感染者,迄今已有若干治疗人乳头瘤病毒相关的良性或恶性疾病的措施,中医药就是其中之一。本文回顾了中医药在人乳头瘤病毒感染及相关疾病中的应用,在体外实验和动物模型的基础上,深入探讨中医药的成分和抗病毒机制。中医药能改善人乳头瘤病毒相关的宫颈癌和生殖器疣等疾病的临床指标,主要机制包括调节细胞凋亡、病毒基因转录和翻译、细胞信号转导通路、免疫功能等。

关键词： Traditional Chinese medicine human papillomavirus(hpv) hpv infection cervical cancer genital warts

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DDX3 is a new potential biomarker for cervical cancer

DDX3 is a new potential biomarker for cervical cancer

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中国生物化学与分子生物学会2016年全国学术会议

作者： Yu He Yuling Liu Ying Cai Shufang Liang State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University /National Collaborative Innovation Center for Biotherapy

DDX3 is a prime target for viral manipulation,and it has multiple functions in viral infection,gene regulation and ***,DDX3 functions in cervical cancer are unclear up to *** our study,we focused on the connections be... 详细信息

关键词： DDX3 hpv infection Cervical cancer

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