检索结果-南通市图书馆

Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors

引用

Bioactive Materials 2024年第12期42卷 299-315页

作者： John Akrofi Kubi Augustine suurinobah Brah Kenneth Man Chee Cheung Andy Chun Hang Chen Yin Lau Lee Kai-Fai Lee Wei Qiao Yibin Feng Kelvin Wai Kwok Yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)PR China shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadPR China shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Applied Oral sciences and Community Dental Care Faculty of DentistryPR China school of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)PR China

Age-related osteoporosis is a metabolic skeletal disorder caused by estrogen deficiency in postmenopausal *** use of anti-osteoporotic drugs such as bisphosphonates and FDA-approved anti-resorptive selective estrogen receptor modulators(sERMs)has been associated with various clinical *** recently discovered a low-molecular-weight biocompatible and osteoanabolic phytoprotein,called hkuot-s2 protein(32 kDa),from Dioscorea opposita Thunb that can accelerate bone defect ***,we demonstrated that the hkuot-s2 protein treatment can enhance osteoblasts-induced ossification and suppress osteoporosis development by upregulating skeletal estrogen receptors(ERs)ERα,ERβ,and GPR30 expressions in ***,hkuot-s2 protein estrogenic activities promoted hMsCs-osteoblasts differentiation and functions by increasing osteogenic markers,ALP,and RUNX2 expressions,ALP activity,and osteoblast biomineralization in *** treatment impaired the hkuot-s2 protein-induced ERs expressions,osteoblasts differentiation,and ***,we demonstrated that the hkuot-s2 protein could bind to ERs to exert osteogenic and osteoanabolic *** results showed that the biocompatible hkuot-s2 protein can exert estrogenic and osteoanabolic properties by positively modulating skeletal estrogen receptor signaling to promote ossification and suppress ***,there is no or limited data if any,on osteoanabolic *** hkuot-s2 protein can be applied as a new osteoanabolic sERM for osteoporosis treatment.

关键词： Ovariectomy(ovx) Osteoporosis Osteoblast functions Estrogen receptors(ERs) hkuot-s2 protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：