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Clinical, Biological, Immunological and Therapeutic Profile of Patients co-Infected with hiv-hbv and/or hcv in Kinshasa, in the Democratic Republic of the congo: Multicenter Cross-Sectional Study

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Open Journal of Gastroenterology 2022年第4期12卷 107-118页

作者： Jean-Paul Mayimona Kimpiatu Aliocha Natuhoyila Nkodila Antoine Wola Yaba Tshimpi Charles Nlombi Mbendi Thérèse Ndarabu Jean Jacques Matimbo Youyou Paka Patrick de Jésus Ngoma Blaise Batumona Trésor Monsere Pitchou Kengibe Jean Robert Rissassi Makulo Mireille Nganga Hippolyte Nani-Tuma Situakibanza Benjamin Longo Mbenza Garstroenterology Department University of Kinshasa Kinshasa Democratic Republic of the Congo Departement of Family Medicine and Primary Health Care Protestant University in Congo Kinshasa Democratic Republic of the Congo Unit of Gastroenterology Clinic Marie Yvette Kinshasa Democratic Republic of the Congo Department of Nephrology University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Clinical Biology University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Infectious Diseases University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Cardiology University of Kinshasa Kinshasa Democratic Republic of the Congo

Background and Objective: hiv infection is often associated with hbv and hcv infection, together leading to high morbidity and mortality in developing countries. The objective of this study is to describe the clinical, biological, immunological and therapeutic profile of patients co-infected with hiv-hbv and/or hcv. Methods: A cross-sectional and descriptive study including 180 people living with hiv (PLWhiv) in the city of Kinshasa province was conducted. Socio-demographic, clinical, biological and serological characteristics were analyzed. Results: The frequency of hiv-hbv/hcv co-infection was 23.9%. The distribution of age and sex of patients did not differ significantly according to co-infection status. The notion of pedicure and manicure was significantly more observed in patients free from viral hepatitis (51.1% versus 32.6%, p = 0.034). The median duration of knowledge of the hiv status which was longer in the co-infected (4 years versus 2 years, p = 0.022). A lower median level of GPT was observed in co-infected compared to other patients (14 IU/L versus 20 IU/L, p = 0.041). Serum albumin (3.1 g/L versus 3.3 g/L, p = 0.034) and prothrombin (58.3% versus 65.6%, p = 0.045) were lower in hiv co-infected-VHB and/or VHC. The median INR was higher in co-infected than in other patients (1.6 versus 1.4;p = 0.009). Patients without therapy Antiretroviral (TARV) medication were more numerous in co-infected (20.9% versus 8.0%, p = 0.025). conclusions: The profile of PLWhiv was dominated by the presence of pedicures and manicures with high transaminases and without anti-viral treatment.

关键词： hiv-hcv-hbv co-infection Clinical Profile Biology TARVs Kinshasa

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Multiplex Rapid Test with Acceptable Diagnosis Performance as a Solution to Increase Diagnosis of Hepatitis B and C Viruses in Pregnant Women in an Area of High Prevalence of Both Hepatitis Viruses Associated with hiv

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Open Journal of Medical Microbiology 2024年第1期14卷 50-65页

作者： Catherine Boni-Cisse Nina Esther Onstira Ngoyi Hermione Dahlia Mossoro-Kpinde Noella Packo Rabi Senekian Hermann Ndoidet Koutou coretha Bokia-Baguida Christelle Luce Bobossi-Gadia Arthur Simplice Sombot-Ndicky Daniel Yvon Gonessa Freddy Samuel Ngbonga Konzapa Voulou Christian Diamant Mossoro-Kpinde Alassane OUATTARA National Center of Medical Oncology and Radiotherapy Abidjan Ivory Cost Department of Microbiology UFR of Medical Sciences University of Cocody Abidjan Ivory Cost Laboratory of Bacteriology-Virology of Teaching Hospital Center of Brazzaville Brazzaville Republic of Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Republic of Congo Department of Labor Medicine Service of HIV and STDs Control in the Workplace Bangui Central African Republic (CAR) Faculty of Health Sciences University of Bangui Bangui Central African Republic National Reference Center of Sexually Transmitted Diseases and Antiretroviral Therapy Bangui Central African Republic National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Medicine Department District Hospital of Alindao Alindao Ouaka Prefecture Central African Republic Doctoral School of Sciences and Technology University of Bangui Bangui Central African Republic coordination of Specialized Study of Clinical Biology University of Bangui Bangui Central African Republic Doctors without Borders Hospital Sica BanguiCRA Laboratory of Medical Analysis of Teaching Hospital Center Mother Elisabeth DOMITIEN of Bimbo Bimbo Central African Republic

Background and Objective: hiv, hepatitis B virus (hbv) and hepatitis C virus (hcv) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of hiv, hcv and hbv co-infections in pregnant women at Bangui community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. hiv, hcv antibodies and hbv antigens were detected using Exacto Triplex? hiv/hcv/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of hiv and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of hiv, hbv, and hcv viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for hiv-hbv, 10.2% for hiv-hcv, 14.7% for hbv-hcv and 6.5% for hiv-hbv-hcv. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 FCFA (60 Euros) by ELISA compared to 10,000 FCFA (15.00 Euros) with Exacto Triplex? hiv/hcv/AgHBs (BioSynex, Strasbourg, France). conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.

关键词： hiv-hcv-hbv co-infection Multiplex Immunochromatographic Rapid Test Central Africa Serology Test cost Diagnostic Accessibility

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