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hiv-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020

引用

Biomedical and Environmental Sciences 2023年第9期36卷 800-813页

作者： YU De E XU Yu Jun LI Mu YANG Yuan LIANG Hua Yue ZHONG Shan Mei QIN Cai LAN Ya Nan LI Da Wei YU Ji Peng PANG Yuan QIN Xue Qiu LIANG Hao ZHU Kao Kao YE Li LIANG Bing Yu Guangxi Key Laboratory of AIDS Prevention and Treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina International School of Public Health and One Health Hainan Medical UniversityHaikou 571199HainanChina Prevention and Treatment Department the Fifth People's Hospital of Hainan Province&Affiliated Dermatology Hospital of Hainan Medical UniversityHaikou 570102HainanChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Life Sciences InstituteGuangxi Medical UniversityNanning 530021GuangxiChina Oncology Medical College Guangxi Medical UniversityNanning 530021GuangxiChina The First Clinical Medical College Guangxi Medical UniversityNanning 530021GuangxiChinaGuangxi Key Laboratory of AIDS Prevention and TreatmentSchool of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina

Objective This study aimed to determine the hiv-1 subtype distribution and hiv drug resistance(hivDR)in patients with ART failure from 2014 to 2020 in Hainan,*** A 7-year cross-sectional study was conducted among hiv/AIDS patients with ART failure in *** used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the hiv subtypes with pol *** resistance mutations(DRMs)were analyzed using the Stanford University hiv Drug Resistance *** A total of 307 hiv-infected patients with ART failure were included,and 241 available pol sequences were *** 241 patients,CRF01_AE accounted for 68.88%,followed by CRF07_BC(17.00%)and eight other subtypes(14.12%).The overall prevalence of hivDR was 61.41%,and the hivDR against non-nucleoside reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)were 59.75%,45.64%,and 2.49%,*** patients,hypoimmunity or opportunistic infections in individuals,and samples from 2017 to 2020 increased the odd ratios of ***,hivDR was less likely to affect female *** common DRMs to NNRTIs were K103N(21.99%)and Y181C(20.33%),and M184V(28.21%)and K65R(19.09%)were the main DRMs against *** The present study highlights the hiv-1 subtype diversity in Hainan and the importance of hivDR surveillance over a long period.

关键词： hiv-1 subtypes Antiretroviral therapy Virological failure Drug resistance

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