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Global Transmission of Human Immunodeficiency Virus 1 subtype c and Its Impact on the circulation of B/c Recombination Strains in china

引用

Infectious Microbes & Diseases 2022年第4期4卷 157-160页

作者： Zhanmou Liu Yanling Liang Yi Feng Kang Li Yiming Shao Guangxi Key Laboratory of AIDS Prevention and Treatment and Guangxi Universities Key Laboratory of Prevention and control of Highly Prevalent Disease School of Public HealthGuangxi Medical UniversityNanningChina Division of Research on Virology and Immunology National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

This study aimed to reconstruct the origin and worldwide epidemic history of human immunodeficiency virus(hiv)1 subtype c and comprehend how hiv-1 subtype c was introduced into and spread throughout china in the formof B/c recombinant *** sequences ofhiv-1 subtype c and some other subtypes deposited before December 31,2020 were downloaded from the Los Alamos hiv Database and the chinese National center for AIDS/STD control and Prevention *** available sequences were screened for quality,and Bayesian analysis was used to build the maximum clade credibility evolutionary tree to analyze and judge the origin and spread of hiv-1 subtype ***-1 subtype c originated in central Africa around 1952,then spread to southern Africa around 1969 and to eastern Africa around ***-1 subtype c fromsouthern Africa was introduced into India in ***-1 subtype c of eastern Africa was introduced into Brazil in *** hiv-1 subtype c was exported to china in three migration events during the period from 1986 to *** two predominant recombinants in china(cRF07_Bc and cRF08_Bc)emerged in 1988 and 1990,*** B/c recombinants,namely,cRF64_Bc,cRF61_Bc and cRF62_Bc,originated in 1993,2002 and 2000,*** study has reconstructed the global origin and evolutionary history of hiv-1 subtype *** addition,our study demonstrated that the chinese hiv-1 subtype c originated from three related Indian lineages around the mid to late 1980s and,since then,has formed some B/c recombinants with subtype B that caused a widespread epidemic in china.

关键词： hiv-1 subtype c origin B/c recombination strains china global

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