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A multicenter study of the clinicopathological characteristics and a risk prediction model of early-stage breast cancer with hormone receptor-positive/human epidermal growth factor receptor 2-low expression

引用

Chinese Medical Journal 2023年第24期136卷 2967-2973页

作者： Ling Xin Qian Wu Chongming Zhan Hongyan Qin Hongyu Xiang Min Gao Xuening Duan Yinhua Liu Jingming Ye Chinese Society of Breast Surgery(CSBrS) Chinese Society of Surgery of Chinese Medical Association Department of Breast and Thyroid Peking University First HospitalBeijing 100034China Jun Yi Tai He Medical Technology Co.Ltd. Beijing 100024China 不详

Background:In light of the significant clinical benefits of antibody-drug conjugates in clinical trials,the human epidermal growth factor receptor 2(her2)-low category in breast cancers has gained increasing ***,we studied the clinicopathological characteristics of Chinese patients with hormone receptor(HR)-positive/her2-low early-stage breast cancer and developed a recurrence risk prediction ***:Female patients with HR-positive/her2-low early-stage breast cancer treated in 29 hospitals of the Chinese Society of Breast Surgery(CSBrS)from Jan 2015 to Dec 2016 were *** clinicopathological data and prognostic information were collected,and machine learning methods were used to analyze the prognostic ***:In total,25,096 patients were diagnosed with breast cancer in 29 hospitals of CSBrS from Jan 2015 to Dec 2016,and clinicopathological data for 6486 patients with her2-low early-stage breast cancer were *** them,5629 patients(86.79%)were *** median follow-up time was 57 months(4,76 months);the 5-year disease-free survival(DFS)rate was 92.7%,and the 5-year overall survival(OS)rate was 97.7%.In total,412 cases(7.31%)of metastasis were observed,and 124(2.20%)patients *** Cox regression analysis revealed that T stage,N stage,lymphovascular thrombosis,Ki-67 index,and prognostic stage were associated with recurrence and metastasis(P2%.Conclusion:Most of patients with her2-low early-stage breast cancer were HR-positive,and patients had favorable outcome;tumor N stage,lymphovascular thrombosis,Ki-67 index,and tumor prognostic stage were prognostic *** HR-positive/her2-low early-stage breast cancer recurrence prediction model established based on the random forest method h

关键词： Breast cancer Hormone positive her2-low expression Multicenter study

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