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Diagnostic Efficacy and Possible Underlying Mechanisms of Noninvasive Clinical Markers in Hepatocellular Carcinoma

Journal of Clinical and Translational Hepatology 2023年第4期11卷 889-898页

作者： Chao-Xu Fu Jun Li Zheng-Da Chen Yan-Ping Cao Hong-Ling Zhang Hong-Ting Sui Bao-Cheng Shan Lei Xu Yang Zhou Min Zhou En-Yue Yang Hong-Xin Piao Department of Internal Medicine Yanbian UniversityYanjiJilinChina Meritco Services ShanghaiChina Jilin Cancer Hospital ChangchunJilinChina Xiamen University Medical Center/Xiang’an Hospital affiliated to Xiamen University XiamenFujianChina Department of Critical Care Medicine Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhouFujianChina The First Affiliated Hospital of Qiqihaer Medical University HeilongjiangChina Beidahuang Group Beian Hospital HeiheHeilongjiangChina Office of Clinical Trials Affiliated Hospital of Yanbian UniversityYanjiJilinChina

Background and Aims:In this study,we aimed to evaluate the diagnostic values of alpha-fetoprotein(AFP),soluble AXL(sAXL),des-γ-carboxy prothrombin(DCP),the aspartate aminotransferase-to-platelet ratio index(APRI),and the gamma-glutamyl transpeptidase-to-platelet ratio(GPR)in hepatocellular carcinoma(hcc)and the possible underlying mechanisms of the correlations between ***:We collected serum samples from 190,128,and 75 patients with hcc,cirrhosis,and chronic viral hepatitis,and from 82 healthy *** levels of AFP,sAXL,and DCP were determined,and APRI and GPR values were *** operating characteristic(ROC)curves were used to analyze the diagnostic value of single and combined ***:We detected significant differences between the hcc group and other groups regarding serum AFP,sAXL,DCP,and APRI *** significantly differed between the hcc group and other groups,except for the liver cirrhosis ***,sAXL,DCP,APRI,and GPR had positive correlations with each other,and AFP showed a higher area under the curve(AUC)and Youden index values,while APRI and DCP showed the highest sensitivity and ***,when AFP was combined with sAXL,DCP,APRI,and GRP,the highest AUC(0.911)and a higher net reclassification improvement value were obtained compared with those obtained for the individual ***:AFP,sAXL,DCP,APRI,and GPR are independent risk factors for hcc,and the diagnostic performance of AFP combined with sAXL,DCP,APRI,and GPR for hcc diagnosis was superior to that of the individual biomarkers.

关键词： Hepatocellular carcinoma hcc-specific biomarkers Alpha-fetoprotein Chronic viral hepatitis Cirrhosis

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