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Consolidation treatment needed for sustained HBsAg-negative response induced by interferon-alpha in hbeag positive chronic hepatitis B patients

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Virologica Sinica 2022年第3期37卷 390-397页

作者： Minghui Li Fangfang Sun Xiaoyue Bi Yanjie Lin Liu Yang Yao Lu Lu Zhang Gang Wan Wei Yi Linqing Zhao Yao Xie Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing100015China Department of Biostatistics Beijing Ditan HospitalCapital Medical UniversityBeijing100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing100015China Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijing100020China

Hepatitis B surface antigen(HBsAg)clearance is considered as functional cure in patients with chronic hepatitis B(CHB).This study aimed to assess the durability of HBsAg clearance achieved by interferon-based therapies in patients with CHB who were originally positive for hepatitis B envelope antigen(hbeag).In this prospective study,hbeag-positive CHB patients with confirmed HBsAg loss under interferon-based therapies were enrolled within 12 weeks from end of treatment and followed up for 48 *** markers,biochemical indicators,and liver imaging examinations were observed every 3–6 *** functional cure was analysed as primary *** associated with sustained HBsAg loss or reversion was also *** rate of HBsAg loss sustainability was 91.8%(212/231).Patients receiving consolidation treatment for 12–24weeks or≥24 weeks had higher rates of sustained HBsAg negativity than those receiving consolidation treatment forhbeag-positivity at cessation of treatment(OR 12.271,95%CI 1.076–139.919,P=0.043)was a predictor of HBsAg ***-alpha induced functional cure was durable and a consolidation treatment of≥12–24 weeks was needed after HBsAg loss in hbeag-positive CHB patients.

关键词： Chronic hepatitis B(CHB) Functional cure hbeag positive HBsAg loss Interferon(IFN)

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Change of Cytokines in Chronic Hepatitis B Patients and hbeag are positively Correlated with HBV RNA, Based on Real-world Study

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 390-397页

作者： Qiqi Zhang Hui Huang Aijun Sun Chunyan Liu Zhidong Wang Feifan Shi Wei Duan Xueying Sun Qi Wang Ping Sun Chunwen Pu Yong Zhang Department of Biobank The Sixth Affiliated People’s Hospital of Dalian Medical UniversityDalianLiaoningChina Outpatient Department of Hepatitis The Sixth Affiliated People’s Hospital of Dalian Medical UniversityDalianLiaoningChina Department of Pathology The Sixth Affiliated People’s Hospital of Dalian Medical UniversityDalianLiaoningChina School of Pharmacy Shenyang Pharmaceutical UniversityShenyangLiaoningChina School of Medicine Deakin UniversityVictoriaAustralia

Background and Aims:The natural course of chronic hepatitis B virus(HBV)infection is widely studied;however,follow-up studies of the same patients are ***,we studied the dynamic changes of serum HBV RNA and cytokines in hepatitis B virus e antigen(hbeag)-positive patients treated with entecavir(ETV)to explore the relationship between the HBV serum viral nucleic acids and host ***:Thirty-three chronic hepatitis B patients who are hbeag-positive,with high virus load(HBV DNA>20,000 IU/mL),and received standard nucleos(t)ide analogue(NA)antiviral therapy(ETV)for more than 48 weeks were *** serum levels of HBV nucleic acids and selected cytokines were measured at 0,12,24,and 48 weeks ***:Serum HBV RNA could still be detected while serum HBV DNA had fallen below the detection limit in patients treated with *** was a strong positive correlation between HBV RNA and hbeag,with a concomitant decrease in the secretion of cytokines from type 1 helper T(Th1)/type 2 helper T(Th2)/interleukin(IL)-17 producing T(Th17)***-4 and IL-10 were the main cytokines negatively associated with serum HBV ***:hbeag can be used to reflect the load of HBV RNA indirectly,because serum HBV RNA has not been widely used in clinical ***,serum IL-4 and IL-10 might be explored in combination with HBV RNA in guiding future clinical antiviral therapy.

关键词： HBV RNA Cytokines hbeag positive Entecavir Chronic hepatitis B

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Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase

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Chinese Medical Journal 2014年第9期127卷 1691-1695页

作者： Song Guangjun Rao Huiying Feng Bo Wei Lai Peking University People's Hospital Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Peking University Beijing 100044 China

Background Some hepatitis B extracellular antigen （hbeag）-positive chronic hepatitis B （CHB） patients in their immune active phase can clear the virus spontaneously and enter into an inactive hepatitis B virus （HBV） carrier state,indicating a benign *** this study,the association between cytokine-inducibie SRC homology 2 domain protein （C/SH） gene polymorphisms at-292 （rs414171） and the spontaneous clearance of HBV in hbeag-positive CHB patients in immune the active phase was *** Seventy hbeag-positive CHB patients in the immune active phase were followed up for 76 weeks without antiviral *** alanine transaminase,aspartate transaminase,HBV DNA,hbeag and hepatitis B extracellular antibody levels were tested *** week 76,27 patients were classified into group A （HBV DNA level below 2 104 IU/ml and the value of hbeag declined below 10％ of the baseline at week 76）,and 43 patients were classified into group B （HBV DNA level higher than 2×104 IU/ml or the value of hbeag did not decline substantially at week 76）.CISH （rs414171） polymorphisms were also tested using the iPLEX *** The HBV DNA levels at week 12 were significantly greater in group B compared with group A （group A：（6.87±1.40） log10IU/ml; group B：（7.61±1.38） log10IU/ml,P=0.034） and the hbeag values were greater in group B at week 28 compared with group A （P=0.001）.The differences in HBV DNA and hbeag values increased between the groups over *** patients in group A and 11 in group B were genotype *** with genotype AT or TT included 11 in group A and 31 in group B （AA *** and TT,odds ratio 4.10 （95％ confidence interval：1.462-11.491）,P=0.006）.Conclusion CISH gene polymorphisms at-292 （rs414171） are associated with HBV clearance in hbeag-positive CHB patients in the immune active phase,and AA is a favorable genotype for this effect.

关键词： CISH gene polymorphism hbeag positive chronic hepatitis B hbeag seroconversion

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