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Chronic hepatitis virus infection increases the risk of pancreatic cancer: a meta-analysis

Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 575-583页

作者： Shuai Xing Zhi-Wei Li Yuan-Feng Tian Li-Min Zhang Ming-Qiang Li Ping Zhou Institute of Organ Transplantation Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Key Laboratory of Organ Transplantation Ministry of Health and KeyLaboratory of Organ TransplantationMinistry of Education Department of Radiology Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Department of Urology Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology

BACKGROUND:Several reports have inconsistently demonstrated that there is an association between hepatitis B virus(hbv)or hepatitis C virus(HCV)infections and pancreatic cancer(PC).The aim of the present meta-analysis is to assess this possible *** SOURCES:Studies were identified by searching available database from January 2000 to July *** associations between PC risk and hepatitis B surface antigen(HBsAg)and its antibody(HBsAb),hepatitis B e antigen(HBeAg)and its antibody(HBeAb),anti-HBcAg antibody(HBcAb),and HCV antibody(anti-HCV)were ***:Eight case-control and two cohort studies were included,and their quality scores were assessed by the modified Newcastle-Ottawa Quality Assessment Scale(NOS).We found that HBsAg and anti-HCV seropositivity significantly increased risk of PC(OR=1.28,95%CI:1.11-1.48 and OR=1.21,95%CI:1.02-1.44).The presence of HBsAb was associated with a statistically significant decrease in the risk of PC(OR=0.40,95%CI:0.20-0.79)and HBeAb(OR=0.62,95%CI:0.39-0.99).HBsAg–/HBcAb+/HBsAb–or HBsAg–/HBcAb+/HBsAb+profile was not related to PC risk(OR=1.57,95%CI:0.83-2.98 and OR=1.24,95%CI:0.72-2.14).CONCLUSIONS:hbv/HCV infection increases the risk of *** and HBeAb seropositivity may be the protective factors against *** is still uncertain whether serological pattern of past exposure to hbv with or without natural immunity is associated with an enhanced probability of this malignancy.

关键词： hepatitis B virus hepatitis C virus hbv status pancreatic cancer meta-analysis

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