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Clinical significance of"anti-hbc alone"in human immunodeficiency virus-positive patients

World Journal of Gastroenterology 2009年第10期15卷 1237-1241页

作者： M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez Infectious Diseases Unit Internal Medicine DepartmentXeral-Cíes University Hospital36204 VigoSpain Faculty of Medicine University of Santiago de Compostela15705 Santiago de CompostelaA CoruaSpain Infectious Diseases Department Vall d' Hebron Hospital08035 BarcelonaSpain Microbiology Department Xeral-Cíes University Hospital36204 VigoSpain

AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection("anti-hbc alone")among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,"anti-hbc alone"and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on"anti-hbc alone"patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55"anti-hbc alone"(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the"anti-hbc alone"pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No"anti-hbc alone" patient tested positive for HBV DNA. CONCLUSION:"Anti-hbc alone"prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury.

关键词：人类免疫缺陷病毒阳性患者临床意义 hbc 丙型肝炎病毒感染乙型肝炎病毒感染 HBV感染标志物丙型肝炎病毒基因型

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“Anti-hbc alone” in human immunodefi ciency virus-positive and immuno-suppressed lymphoma patients

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World Journal of Gastroenterology 2009年第30期15卷 3834-3835页

作者： Yu Xuan Koo Daniel SW Tan Iain BH Tan Richard Quek Miriam Tao Soon Thye Lim Yong Loo Lin School of Medicine NationalUniversity of Singapore10 Medical DriveSingapore 117597Singapore Department of Medical Oncology National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore

Hepatitis B virus (HBV) infection is endemic in various parts of the world. A proportion of patients have resolved prior exposure to HBV, as evidenced by the clearance of circulating hepatitis B surface antigen and the appearance of antibody to hepatitis B core antigen (anti-hbc), which could produce protective antibody to hepatitis B surface antigen (anti-HBs). With time, anti-HBs in some patients may become negative. Such patients are described as having occult HBV infection or "anti-hbc alone". In the context of immunodef icient patients, such as HIV patients or lymphoma patients undergoing immunosuppressive immunotherapy, the lack of protective anti-HBs may increase the risk of hepatitis B reactivation. Serum HBV DNA testing may be necessary in "anti-hbc alone" patients, to detect patients at a high risk of developing HBV infection allowing appropriate prophylactic management.

关键词：人类免疫缺陷病毒免疫反应 hbc 淋巴瘤患者阳性乙型肝炎表面抗原乙型肝炎病毒

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Analysis of wave propagation on human body based on stratified media model

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Journal of Central South University 2013年第12期20卷 3545-3551页

作者：马力沈海斌刘磊 Institute of VLSI Design Zhejiang University Institute of Advanced Technology of Electrical and Electronic Engineering Zhejiang University

Human body communication(hbc) is a promising near-field communication(NFC) method emerging in recent years. But existing theoretical models of hbc are too simple to simulate the wave propagation on human body. In this work, in order to clarify the propagation mechanism of electromagnetic wave on human body, a surface waveguide hbc theoretical model based on stratified media cylinder is presented. A numerical model analyzed by finite element method(FEM) is used for comparing and validating the theoretical model. Finally, results of theoretical and numerical models from 80 MHz to 200 MHz agree fairly well, which means that theoretical model can characterize accurate propagation mechanism of hbc signal. Meanwhile, attenuation constants derived from two kinds of models are within the range from 1.64 to 3.37, so that hbc signal can propagate effectively on human body. The propagation mechanism derived from the theoretical model is useful to provide design information for the transmitter and the modeling of the propagation channel in hbc.

关键词：介质模型波传播传播机制数值模型 hbc 波的传播表面波导分层介质

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A thermosensitive chitosan-based hydrogel for controlled release of insulin

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Frontiers of Materials Science 2014年第2期8卷 142-149页

作者： Ting-Ting GAO Ming KONG Xiao-Jie CHENG Gui-Xue XIA Yuan-Yuan GAO Xi-Guang CHEN Dong Su CHA HyunJin PARK ColLege of Marine Life Science Ocean University of China Qingdao 266003 China College of Life Sciences and Biotechnology Korea University Seoul 136-701 Korea

现在的学习为胰岛素的控制版本在综合瞄准 thermosensitive hydrogel。根据一个修改方法， hydroxybutyl chitosan (hbc ) hydrogel 拥有了热敏感被准备它能在 25T 上形成 hydrogel

关键词：控制释放热敏感性水凝胶胰岛素糖基成纤维细胞 hbc 温敏凝胶

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三维氧化石墨烯电场敏感水凝胶的制备及其经皮控释给药研究

三维氧化石墨烯电场敏感水凝胶的制备及其经皮控释给药研究

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作者：董萌辽宁大学

学位级别：硕士

氧化石墨烯(Graphene oxide,GO)是对石墨进行高度氧化改造后所获得的重要衍化物,自问世以来凭借其优异的物理和化学特性在医药学领域得到了广泛应用。三维氧化石墨烯(3D@GO),顾名思义是由二维氧化石墨烯组装而成的三维结构。与二维结构... 详细信息

氧化石墨烯(Graphene oxide,GO)是对石墨进行高度氧化改造后所获得的重要衍化物,自问世以来凭借其优异的物理和化学特性在医药学领域得到了广泛应用。三维氧化石墨烯(3D@GO),顾名思义是由二维氧化石墨烯组装而成的三维结构。与二维结构比较,三维结构的氧化石墨烯不但继承了石墨烯固有的理化特性,而且三维多孔的纳米分子结构还使它具备比表面积大、电子传输力高、机械强度好等的优良特点。吲达帕胺是治疗高血压的一线药物,市面上常制备为口服制剂出售,这种给药方式由于口服给药吸收较快且药物半衰期短,会导致需要患者频繁服药,经常出现胃肠道刺激等问题。此外,由于抗高血压药物存在长期给药的特性,长时间用药会引起低血钠和低血钾等副作用。经皮给药方式可有效减少给药的次数,以降低副作用,并增加对病人顺应性。本研究选择吲达帕胺为模型药物,系统性研究电场调控下3D@GO-hbc对吲达帕胺的经皮控释给药过程并分析其释放机制。首先将氧化石墨烯通过自组装法制备为三维结构的氧化石墨烯,然后再将以壳聚糖为主要原料,1,2-环氧丁烷为醚化剂使用,以异丙醇溶液为主要分散系统,得到了改性水溶性壳聚糖衍生物hbc。在此基础上,将3D@GO与羟丁基壳聚糖超声融合,制备了具有电场敏感性的3D@GO-hbc,作为一种能够在电场条件下控制释放药物的载体并进行了不同电场强度调控下的药物经皮释放实验。本课题主要包括以下四个部分:(1)课题首先采用改进的Hummers法对石墨烯进行了高度氧化使其改性,成功合成了片层状氧化石墨烯,并对合成的改性产物进行表征。结果表明,制备的GO为2D片层状结构,证明含氧官能团被成功引入到石墨烯表面及边缘了。通过将制得的GO片状物固体超声溶解得到GO溶液。GO溶液分散均一,稳定性良好,未产生聚集或沉淀。(2)以高脱乙酰度壳聚糖为原材料,以1,2-环氧丁烷为反应醚化剂,以异丙醇溶液为分散体系,在强碱性环境下向壳聚糖分子结构上成功导入了羟丁基制备了水溶性壳聚糖衍生物,并通过壳聚糖高分子链间的相互缠绕和氢键作用形成hbc。实验结果表明,合成的hbc具有蜂窝状网络结构,且随浓度的增大网格越发致密。之后采用流变学手段考察了产物成胶温度和成胶时间,浓度5%的hbc在4℃与20.4℃之间完成了溶胶-凝胶态的转变,证明合成的hbc具有良好的温敏特性。(3)以上文制得的GO为原料,通过自组装法合成了三维结构的氧化石墨烯,并对合成的3D@GO进行表征及电学性质研究。制备的3D@GO与GO红外图类似,证明其延续了石墨烯固有的理化性质,且经过测试其电导率良好,具备成为电敏感性药物载体的条件。(4)超声融合3D@GO与羟丁基壳聚糖并装载吲达帕胺后得到终产物水凝胶3D@GO-hbc-IND,并对其进行处方优化和表征。以吲达帕胺药物累积释放量(Q%)为指标,制备终产物水凝胶并进行了不同电压下药物经皮控制释放实验。结果表明,合成的终产物水凝胶呈现均一的浅棕褐色,具有一定的机械强度,说明3D@GO在其中均匀分布。通过溶胀度测试,终产物水凝胶的溶胀度随着电场强度的升高而明显增大,具有电敏感性。通过在四个依次增大的电流强度下测定24 h内模型药物吲达帕胺的透皮累积释放量,实验结果显示,在外加电场条件下,随着电流强度的增大吲达帕胺24 h的累积释放量明显逐渐高于未加电场条件下吲达帕胺的累计释放量。说明3D@GO-hbc在外加电场下表现出良好的电敏感性,可作为经皮控制释放药物的载体进一步研究。

关键词： 3D@GO hbc 经皮给药电场控释吲达帕胺

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BOTTOM MESONS(B=±1)B^+=u,B^0=d,B^0=db,B^-=b,similarly for B~*'s

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Chinese Physics C 2014年第9期38卷 1042-1223页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerr D.Chakraborty M.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu M.Doser M.Drees H.K.Dreiner D.A.Edwards S.Eidelman J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes M.Heffner B.Heltsley J.J.Hernandez-Rey K.Hikasa A.Hocker J.Holder A.Holtkamp J.Huston J.D.Jackson K.F.Johnson T.Junk M.Kado D.Karlen U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss M.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin T.M.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.Maltoni T.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews D.Milstead P.Molaro K.Monig F.Moortgat M.J.Mortonson H.Murayama K.Nakamura M.Narain P.Nason S.Navas M.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock M.Pennington S.T.Petcov Kavli IPMU A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharma S.R.Sharpe M.Silari T.Sjostrand P.Skands J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sumiyoshi M.J.Syphers F.Takahashi M.Tanabashi J.Terning L.Tiator M.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.Valencia G.Venanzoni M.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg M.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Womersley C.L. University of Minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of Maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland Lab.Nazionali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest National Laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COMPAS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance Max-Planck-Institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-Maximilians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA Kavli Institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

Many measurements of B decays involve admixtures of B hadrons. Previously we arbitrarily included such admixtures in the B±section, but because of their importance we have created two new sections：

关键词： B~0=db,B hbc BOTTOM MESONS B~0 b,similarly for B

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∧ BARYONS(S=-1,I=0)∧~0=uds

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Chinese Physics C 2014年第9期38卷 1452-1470页

We have omitted some results that have been superseded by later experiments. See our earlier editions.

关键词： hbc uds BARYONS I

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CHARMED BARYONS(C=+1)∧_c^+=udc,∑_c^(++)=uuc,∑_c^+=udc,∑_c^0=ddc,≡_c^+=usc,≡_c^0=dsc,Ω_c^0=ssc

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Chinese Physics C 2014年第9期38卷 1514-1534页

CHARMED BARYONS Revised March 2012 by C.G. Wohl （LBNL）. There are 17 known charmed baryons, and four other candidates not well enough established to be promoted to the Summary Tables.＊ Fig. l（a） shows the mass sp... 详细信息

关键词： hbc c~0 udc usc uuc CHARMED BARYONS

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b MESONS

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Chinese Physics C 2014年第9期 1336-1367+547页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerr D.Chakraborty M.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu M.Doser M.Drees H.K.Dreiner D.A.Edwards S.Eidelman J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes M.Heffner B.Heltsley J.J.Hernandez-Rey K.Hikasa A.Hocker J.Holder A.Holtkamp J.Huston J.D.Jackson K.F.Johnson T.Junk M.Kado D.Karlen U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss M.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin T.M.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.Maltoni T.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews D.Milstead P.Molaro K.Monig F.Moortgat M.J.Mortonson H.Murayama K.Nakamura M.Narain P.Nason S.Navas M.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock M.Pennington S.T.Petcov Kavli IPMU A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J,L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharma S.R.Sharpe M.Silari T.Sjostrand P.Skands J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sumiyoshi M.J.Syphers F.Takahashi M.Tanabashi J.Terning L.Tiator M.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.Valencia G.Venanzoni M.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg M.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Womersley C.L. Prince Consort Road London SW7 2AZ UK Jefferson Lab 12000 Jefferson Ave. Newport News VA 23606 USA Department of Physics University of Virginia MD 20742-4111 PO Box 400714 Charlottesville VA 22904 USA Fermi National Accelerator Laboratory P.O.Box 500 Batavia IL 60510 USA Kavli Institute for Cosmological Physics USA University of Chicago Chicago IL 60637-1433 USA Department of Physics and Astronomy University of Sussex Falmer Brighton BN1 9QH UK Department of Physics Albert Einstein Center for Fundamental Physics Northern Illinois University DeKalb IL 60115 USA Department of Physics and Astronomy University of California Irvine CA 92697-4575 USA Michigan State University Universitat Bern Dept.of Physics and Astronomy East Lansing MI 48824-2320 USA Department of Physics Royal Holloway University of London Egham Surrey TW20 OEX UK CH-3012 Bern INFN-Sezione di Napoli Complesso Universitario Monte Sant'Angelo Via Cintia 80126 Napoli Italy Institut des Hautes Etudes Scientifiques F-91440 Bures-sur-Yvette France Departamento de Fisica FCEyN Switzerland Universidad de Buenos Aires Pab.1 Ciudad Universitaria (1428) Capital Federal Argentina Department of Physics and Astronomy Northwestern University Evanston IL 60208 USA Lab.Nazionali di Frascati dell'INFN Department of Physics University of Colorado at Boulder Boulder CO 80309 USA Nikhef P.O.Box 41882 1009 DB Amsterdam the Netherlands Institute for Particle Physics CP 13 ETH Zurich 8093 Zurich Switzerland Universitat Bonn Physikalisches Institut Nussallee 12 D-53115 Bonn Germany Deutsches Elektronen-Synchrotron DESY Notkestraβe 85 via E.Fermi D-22607 Hamburg Germany Budker Institute of Nuclear Physics SB RAS Novosibirsk State University Novosibirsk 630090 Russia Departamento de Fisica Teorica Instituto de Fisica Universidad Nacional Autonoma de Mexico Mexico D.F.04510 40 University of Minnesota Mexico Institut fur Physik Johannes-Gutenberg Universitat Mainz D-55099 Mainz Germany Department of Astronomy University of Illinois 1002 W.Green St. Urbana IL 61801 I-00044 Frasc

关键词： hbc MESONS

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LONG-TERM EFFICACY AND IMMUNOLOGICAL MEMORY OF PLASMA-DERIVED HEPATITIS B VACCINE 11 YEARS AFTER INITIAL INOCULATION

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Academic Journal of Xi'an Jiaotong University 2000年第2期12卷 122-125页

作者：王学良徐慧文庄贵华 Department of Epidemiology Med. Coll. of Xi'an Jiaotong Univ. Xi'an 710061 China

Objective To assess the efficacy and the immunological memory of plasma-derived hepatitis B vaccine 11 years after the initial inoculation. Methods: A randomized, double-blind and placebo-controlled trial design was used. Results: The immunogenicity and protection rate of the vaccine were good 11 years after vaccination, however, from 9 to 11 years after vaccination, the person year HBV infection rate showed no noticeable difference between the vaccine group and placebo-controls. Furthermore, the immunological memory remained 11 years after inoculation, but was significantly lower than that observed in the past 10 years. Conclusion: Vaccine protection wanes over the years. More information is needed to define the appropriate time for vaccine booster doses.

关键词： hbc HBV PLASMA-DERIVED HEPATITIS B VACCINE 11 YEARS AFTER INITIAL INOCULATION LONG-TERM EFFICACY AND IMMUNOLOGICAL MEMORY OF

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