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Dual roles of the Arabidopsis PEAT complex in histone H2A deubiquitination and H4K5 acetylation

Molecular Plant 2023年第11期16卷 1847-1865页

作者： Si-Yao Zheng Bin-Bin Guan Dan-Yang Yuan Qiang-Qiang Zhao Weiran Ge Lian-Mei Tan Shan-Shan Chen Lin Li She Chen Rui-Ming Xu Xin-Jian He College of Life Sciences Beijing Normal UniversityBeijingChina National Institute of Biological Sciences BejingChina National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijingChina School of Life Sciences University of Chinese Academy of SciencesBeijingChina Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeilingChina

Histone H2A monoubiquitination is associated with transcriptional repression and needs to be removed by deubiquitinases to facilitate gene transcription in ***,the deubiquitinase responsible for genome-wide H2A deubiquitination in plants has yet to be *** this study,we found that the previously identified PWWP-EPCR-ARID-TRB(PEAT)complex components interact with both the ubiquitin-specific protease UBP5 and the redundant histone acetyltransferases ham1 and ham2(ham1/2)to form a larger version of PEAT complex in Arabidopsis ***5 functions as an H2A deubiquitinase in a nucleosome substrate-dependent manner in vitro and mediates H2A deubiquitination at the whole-genome level in ***1/2 are shared subunits of the PEAT complex and the conserved NuA4 histone acetyltransferase com-plex,and are responsible for histone H4K5 *** the PEAT complex,the PWWP components(PWWP1,PWWP2,and PWWP3)directly interact with UBP5 and are necessary for UBP5-mediated H2A deu-biquitination,while the EPCR components(EPCR1 and EPCR2)directly interact with ham1/2 and are required for ham1/2-mediated ***,our study not onlyidentifies dual roles of thePEAT com-plex in H2A deubiquitination and H4K5 acetylation but also illustrates how these processes collaborate at the whole-genome level to regulate the transcription and development in plants.

关键词： histone H2A deubiquitination H4K5 acetylation UBP5 ham1 NuA4 PEAT

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The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis

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Journal of Integrative Plant Biology 2022年第4期64卷 901-914页

作者： Jin-Xing Zhou Xiao-Min Su Si-Yao Zheng Chan-Juan Wu Yin-Na Su Zhaodi Jiang Lin Li She Chen Xin-Jian He College of Life Sciences Beijing Normal UniversityBeijing 100091China National Institute of Biological Sciences Beijing 102206China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 100084China

Although two Enhancer of Polycomb-like proteins,EPL1 A and EPL1 B(EPL1 A/B),are known to be conserved and characteristic subunits of the Nu A4-type histone acetyltransferase complex in Arabidopsis thaliana,the biological function of EPL1 A/B and the mechanism by which EPL1 A/B function in the complex remain ***,we report that EPL1 A/B are required for the histone acetyltransferase activity of the Nu A4 complex on the nucleosomal histone H4 in vitro and for the enrichment of histone H4 K5 acetylation at thousands of protein-coding genes in *** results suggest that EPL1 A/B are required for linking the Nu A4 catalytic subunits HISTONE ACETYLTRANSFERASE OF THE MYST FAMILY 1(ham1)and ham2 with accessory subunits in the Nu A4 ***1 A/B function redundantly in regulating plant development especially in chlorophyll biosynthesis and *** EPL1 A/B-dependent transcription and H4 K5 Ac are enriched at genes involved in chlorophyll biosynthesis and *** also find that EAF6,another characteristic subunit of the Nu A4 complex,contributes to *** results suggest that the Arabidopsis Nu A4 complex components function as a whole to mediate histone acetylation and transcriptional activation specifically at light-responsive genes and are critical for photomorphogenesis.

关键词： chlorophyll EPL1A ham1 histone acetyltransferase NuA4 photosynthesis transcription

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