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第八届海峡两岸心血管科学研讨会

作者：郭进荣邱碧莹许尧钦许淑芬张明温王哲川林茂村张菁萍邱仲庆 Department of Neurosurgery Chi Mei Medical Center Department of Biotechnology Southern Taiwan University Department of chinese Medicine Chi Mei Medical Center Department of Nursing Shu-Zen College of Medicine and Management Department of Electrical Engineering Southern Taiwan University Department of Medical Research Chi Mei Medical Center

＜正＞Objective The use of hypothermia therapy has been associated as a potential treatment for a number of medical conditions including cardiac *** therapy had protective effects on heart disease, but the mechanism still *** cultures have been proven to be useful in understanding the pathophysiology of cardiac damage during simulated ischemia and during *** investigated whether hypothermic therapy may protect against ischemia/ reperfusion injury and detrimental roles in the myocardium depending on the level of apoptosis,and discuss potential mechanisms by which apoptosis provides protection or induction of cell *** To deal with question,we exposed h9c2 cardiac muscle cells to an in vitro simulated ischemia（subtract - free medium plus hypoxia at 37℃） for induction of cell loss and examined the direct effects of mild hypothermia（subtract - free medium plus hypoxia at 32℃） on cell *** At simulated ischemia and hypoxia there was approximately 50%loss of cell viability accompanied by caspase -3 *** model of cell death due to hypoxia and ischemia in h9c2 cardiac cells belonged to apoptosis significant decrease in cytotoxicity,the percentage of apoptotic cells,and caspase -3 overproduction were observed following mild hypothermia ***,augmented to normal level of hSP 27 was observed in hypothermia group following ischemia *** also found that the increase of hSP 27 by hypothermia was associated with low level of cell *** The data indicate that mild hypothermia may act via hSP 27 overexpression to inhibit ischemic injury - induced apoptosis in cardiac muscle cells.

关键词： h9c2 cell apoptosis hypoxia heat shock protein

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Paeoniflorin reduces cardiotoxicity of aconitine in h9c2 cells

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中国药理学与毒理学杂志 2019年第9期33卷 689-689页

作者： LI J ZhANG Sh hE D WANG JF LI JQ School of medicine University of Electronic Science and Technology of China&Department of PharmacySichuan Provincial People′s HospitalChengdu 610072China Personalized Drug Therapy Key Laboratory of Sichuan Province&Sichuan Academy of Medical Sciences Chengdu 610072China

OBJEcTIVE Aconitine(AcO)as the main active component in Aconitum carmichaelii debeaux(family Ranunlaceae),has highly toxicity in heart and the mechanisms are not clear ***(PF),the main chemical ingredient in herbaceous peony,can protect heart hurt by antioxidant,vasodilator effect and other *** this study,we focused on investigating the mechanism of PF reducing the cardiotoxicity of *** We chose h9c2 cells as experimental ***,Western blotting and real-time PcR were used to measure cell proliferation,apoptosis,ion channels and oxidative *** cell proliferation in AcO+PF group was significantly increased compared with AcO group;the ratio with Bcl-2 and Bax and the level of p53 were upregulated by PF,while the level of caspase-3 was lightly *** expression of ScN5A mRNA significantly was increased in AcO+PF group,while the expres⁃sion of RyR2 and cx43 mRNA was *** with AcO group,extracellular LDh and intracellular MDA were highly decreased,while intracellular SOD was *** cardiotoxicity of AcO in h9c2 cells was signifi⁃cantly decreased by PF.

关键词： acontine paeoniflorin cardiotoxicity h9c2 cell

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