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Antibodies elicited by newcastle disease virus-vectored h7n9 avian influenza vaccine are functional in activating the complement system

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Journal of Integrative Agriculture 2024年第6期23卷 2052-2064页

作者： Zenglei hu Ya huang Jiao hu Xiaoquan Wang Shunlin hu Xiufan Liu Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China Yangzhou UniversityYangzhou 225009China Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou 225009China

h7n9 subtype avian influenza virus poses a great challenge for poultry *** disease virus(nDV)-vectored h7n9 avian influenza vaccines(nDV_(vec)h7n9)are effective in disease control because they are protective and allow mass *** note,these vaccines elicit undetectable h7n9-specific hemagglutination-inhibition(hI)but high IgG antibodies in ***,the molecular basis and protective mechanism underlying this particular antibody immunity remain ***,immunization with an nDV_(vec)h7n9 induced low anti-h7n9 hI and virus neutralization titers but high levels of hemagglutinin(hA)-binding IgG antibodies in *** residues(S150,G151 and S152)in hA of h7n9 virus were identified as the dominant epitopes recognized by the nDV_(vec)h7n9 immune *** transferred nDV_(vec)h7n9 immune serum conferred complete protection against h7n9 virus infection in *** nDV_(vec)h7n9 immune serum can mediate a potent lysis of hA-expressing and h7n9 virus-infected cells and significantly suppress h7n9 virus *** activities of the serum were significantly impaired after heat-inactivation or treatment with complement inhibitor,suggesting the engagement of the complement ***,mutations in the 150-SGS-152 sites in hA resulted in significant reductions in cell lysis and virus neutralization mediated by the nDV_(vec)h7n9 immune serum,indicating the requirement of antibody-antigen binding for complement ***,antibodies induced by the nDV_(vec)h7n9 can activate antibody-dependent complement-mediated lysis of h7n9 virus-infected cells and complement-mediated neutralization of h7n9 *** findings unveiled a novel role of the complement in protection conferred by the nDV_(vec)h7n9,highlighting a potential benefit of engaging the complement system in h7n9 vaccine design.

关键词： h7n9 subtype avian influenza virus nDV vector vaccine antibody immunity complement protection

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