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Controlled Self-assembly of Thermo-responsive Amphiphilic h-shaped polymer for Adjustable Drug Release

Chinese Journal of polymer Science 2018年第3期36卷 406-416页

作者： Yang Bai Fang-Yuan Xie Wei Tian College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an 710021China Ministry of Education Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Macromolecular Science and Technology School of ScienceNorthwestern Polytechnical UniversityXi’an 710072China Department of Pharmacy Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghai 200438 China

Despite the fact that some progress has been made in the self-assembly of h-shaped polymers, the corresponding self-assemblies that respond to external stimulus and are further utilized to adjust the release of drugs are still deficient. The stimuli-responsive segments with amphiphilic h-shaped structure are generally expected to enhance the controllability of self-assembly process. The synthesis and self-assembly behavior of thermo-responsive amphiphilic h-shaped polymers with poly（ethylene glycol）（PEG）, polytetrahydrofuran （PThF） and poly（N-isopropyl acrylamide）（PNIPAM） as building blocks are reported in this paper. The inner architecture structure and size of complex micelles formed by h-shaped self-assemblies were effectively adjusted when the solution temperature was increased above the lower critical solution temperature of PNIPAM segments. Furthermore, it was found that the architecture of self-assemblies underwent a transition from the complex micelles based on primary micelles with hybrid PEG/PNIPAM shells to large complex micelles based on primary micelles with hybrid PThF/PNIPAM cores and PEG shells during the thermal-induced self-assembly process. The adjustable release rate ofdoxorubicin （DOX） from the DOX-loaded complex micelles and basic cell experiments further proved the feasibility of these self-assemblies as the thermal-responsive drug delivery system.

关键词： h-shaped polymer Thermo-responsive polymer Amphiphilic polymer Self-assembly Drug release

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