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Characterization of gut microbial and metabolite alterations in faeces of Goto Kakizaki rats using metagenomic and untargeted metabolomic approach

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World Journal of Diabetes 2023年第3期14卷 255-270页

作者： Jin-Dong Zhao Min Sun Yan Li Chan-Juan Yu Ruo-Dong Cheng Si-Hai Wang Xue Du Zhao-Hui Fang Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Graduate School Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina School of Life Sciences Anhui UniversityHefei 230039Anhui ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKGROUND In recent years,the incidence of type 2 diabetes(T2DM)has shown a rapid growth *** Kakizaki(GK)rats are a valuable model for the study of T2DM and share common glucose metabolism features with human T2DM patients.A series of studies have indicated that T2DM is associated with the gut microbiota composition and gut *** aimed to systematically characterize the faecal gut microbes and metabolites of GK rats and analyse the relationship between glucose and insulin *** To evaluate the gut microbial and metabolite alterations in GK rat faeces based on metagenomics and untargeted *** Ten GK rats(model group)and Wistar rats(control group)were observed for 10 wk,and various glucose-related indexes,mainly including weight,fasting blood glucose(FBG)and insulin levels,homeostasis model assessment of insulin resistance(HOMA-IR)and homeostasis model assessment ofβcell(HOMA-β)were *** faecal gut microbiota was sequenced by metagenomics,and faecal metabolites were analysed by untargeted *** metabolic pathways were evaluated based on the differential metabolites identified,and the correlations between blood glucose and the gut microbiota and metabolites were *** The model group displayed significant differences in weight,FBG and insulin levels,HOMA-IR and HOMA-βindexes(Pgut microbiota structure compared with the control *** results demonstrated significantly decreased abundances of Prevotella ***:604 and Lactobacillus murinus(P<0.05)and a significantly increased abundance of Allobaculum stercoricanis(P<0.01)in the model group.A correlation analysis indicated that FBG and HOMA-IR were positively correlated with Allobaculum stercoricanis and negatively correlated with Lactobacillus *** orthogonal partial least squares discriminant analysis suggested that the faecal metabolic profiles differed between the model and control *** pote

关键词： Type 2 diabetes mellitus gut microbial Metabolites Goto-Kakizaki rats Metagenomics Untargeted metabolomics

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