检索结果-南通市图书馆

The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 830-841页

作者： Yu Jiang Mengxuan Du Lisheng Xie Minzhi Jiang Yaokun Zhang Mingxia Bi Chang Liu Hongwei Liu Shuangjiang Liu State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071000China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Many studies have revealed that gut microbes modulate host metabolism.In this study,we characterized the therapeutic effects of a novel gut commensal Luoshenia tenuis against host metabolic disorders.First,by in silico analysis,we demonstrated that the L.tenuis was prevalent in the gut microbiomes of healthy humans but were depleted specifically in obesity cohorts.Further in vitro cultivation revealed that L.tenuis produced short chain fatty acids that were verified to modulate host metabolism and some other volatile metabolites to benefit hosts by anti-inflammation and anti-tumor.Second,gavage of the L.tenuis significantly decreased the body weight gain and food intake of high-fat diet-feeding C57BL/6J mice,which was in parallel with the changed expression level of genes related to satiety and feeding behavior.We then performed the gavage trial using diet induced obese mice,and it revealed that the administration of L.tenuis alleviated significantly the abnormal glucose and lipid metabolisms and reduced the inflammatory response.In summary,this study revealed a previously-unknown human gut commensal microbe that benefited host metabolism,and set the stage for the development of novel next-generation probiotic applicable for treatment of obesity and related metabolic disorders.

关键词： Luoshenia tenuis gut microbe Feeding behavior Obesity Next-generation probiotic

Clinical Report on the Treatment of Post-stroke Cognitive Impairment Based on microbe-gut-Brain Axis Theory

在线全文

学校读者我要写书评

暂无评论

Medicinal Plant 2022年第2期13卷 70-72,86页

作者： Zhonghui ZENG Lingyun ZHOU Zeyu ZHANG Guizhou University of Traditional Chinese Medicine Guiyang 550002 China Cadre Health Care Department The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550003 China

Based on the close relationship between MGBA and PSCI,one PSCI related case is reported,and it is emphasized to improve clinicians'understanding of MGBA theory in the treatment of PSCI,thereby providing new ideas for ... 详细信息

关键词： microbe-gut-brain axis Post-stroke cognitive impairment gut microbe

Consistent Alterations of Human Fecal microbes After Transplantation into Germ-free Mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2022年第2期20卷 382-393页

作者： Yanze Li Wenming Cao Na L Gao Xing-Ming Zhao Wei-Hua Chen MOE Key Laboratory of Molecular Biophysics Hubei Key Laboratory of Bioinformatics and Molecular-imagingDepartment of Bioinformatics and Systems BiologyCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Institute of Science and Technology for Brain-Inspired Intelligence(ISTBI) Fudan UniversityShanghai 200433China College of Life Science Henan Normal UniversityXinxiang 453007China

Fecal microbiota transplantation(FMT)of human fecal samples into germ-free(GF)mice is useful for establishing causal relationships between the gut microbiota and human phenotypes.However,due to the intrinsic differences between human and mouse intestines and the different diets of the two organisms,it may not be possible to replicate human phenotypes in mice through FMT;similarly,treatments that are effective in mouse models may not be effective in humans.In this study,we aimed to identify human gut microbes that undergo significant and consistent changes(i.e.,in relative abundances)after transplantation into GF mice in multiple experimental settings.We collected 16S rDNA-seq data from four published studies and analyzed the gut microbiota profiles from 1713 human–mouse pairs.Strikingly,on average,we found that only 47%of the human gut microbes could be re-established in mice at the species level,among which more than 1/3 underwent significant changes(referred to as“variable taxa”).Most of the human gut microbes that underwent significant changes were consistent across multiple human–mouse pairs and experimental settings.Consequently,about 1/3 of human samples changed their enterotypes,i.e.,significant changes in their leading species after FMT.Mice fed with a controlled diet showed a lower enterotype change rate(23.5%)than those fed with a noncontrolled diet(49.0%),suggesting a possible solution for rescue.Most of the variable taxa have been reported to be implicated in human diseases,with some recognized as the causative species.Our results highlight the challenges of using a mouse model to replicate human gut microbiota-associated phenotypes,provide useful information for researchers using mice in gut microbiota studies,and call for additional validations after FMT.An online database named FMT-DB is publicly available at http://fmt2mice.***.info/#/.

关键词： Germ-free mice Fecal microbiota transplantation gut microbe Enterotype 16S rDNA

Regulatory effect of gut microbes on blood pressure

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2022年第6期5卷 513-531页

作者： Dong Yan Ye Sun Xiaoyue Zhou Wenhao Si Jieyu Liu Min Li Minna Wu Xinxiang Key Laboratory of Pathogenic Biology Department of Pathogenic BiologySchool of Basic Medical SciencesXinxiang Medical UniversityXinxiangChina Institute of Medical Laboratory Animal Science Chinese Academy of Medical Sciences&Comparative Medical CenterPeking Union Medical CollegeBeijingChina Department of Dermatology the First Affiliated Hospital of Xinxiang Medical UniversityXinxiangChina

Hypertension is an important global public health issue because of its high morbidity as well as the increased risk of other diseases.Recent studies have indicated that the development of hypertension is related to the dysbiosis of the gut microbiota in both animals and humans.In this review,we outline the interaction between gut microbiota and hypertension,including gut microbial changes in hypertension,the effect of microbial dysbiosis on blood pressure(BP),indicators of gut microbial dysbiosis in hypertension,and the microbial genera that affect BP at the taxonomic level.For example,increases in Lactobacillus,Roseburia,Coprococcus,Akkermansia,and Bifidobacterium are associated with reduced BP,while increases in Streptococcus,Blautia,and Prevotella are associated with elevated BP.Furthermore,we describe the potential mechanisms involved in the regulation between gut microbiota and hypertension.Finally,we summarize the commonly used treatments of hypertension that are based on gut microbes,including fecal microbiota transfer,probiotics and prebiotics,antibiotics,and dietary supplements.This review aims to find novel potential genera for improving hypertension and give a direction for future studies on gut microbiota in hypertension.

关键词： blood pressure diversity gut microbe hypertension probiotic

Bile acids and microbes in metabolic disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第48期28卷 6846-6866页

作者： Dhiraj Kumar Sah Archana Arjunan Sun Young Park Young Do Jung Department of Biochemistry Chonnam National UniversityGwangju 501190South Korea Department of Internal Medicine Chonnam National UniversityGwangju 501190South Korea

Bile acids(BAs)serve as physiological detergents that enable the intestinal absorption and transportation of nutrients,lipids and vitamins.BAs are primarily produced by humans to catabolize cholesterol and play crucial roles in gut metabolism,microbiota habitat regulation and cell signaling.BA-activated nuclear receptors regulate the enterohepatic circulation of BAs which play a role in energy,lipid,glucose,and drug metabolism.The gut microbiota plays an essential role in the biotransformation of BAs and regulates BAs composition and metabolism.Therefore,altered gut microbial and BAs activity can affect human metabolism and thus result in the alteration of metabolic pathways and the occurrence of metabolic diseases/syndromes,such as diabetes mellitus,obesity/hypercholesterolemia,and cardiovascular diseases.BAs and their metabolites are used to treat altered gut microbiota and metabolic diseases.This review explores the increasing body of evidence that links alterations of gut microbial activity and BAs with the pathogenesis of metabolic diseases.Moreover,we summarize existing research on gut microbes and BAs in relation to intracellular pathways pertinent to metabolic disorders.Finally,we discuss how therapeutic interventions using BAs can facilitate microbiome functioning and ease metabolic diseases.

关键词： Bile acids Metabolic diseases gut microbe Diabetic mellitus Obesity Hypercholesterolemia

gut health:The results of microbial and mucosal immune interactions in pigs

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2021年第2期7卷 282-294页

作者： Jie Peng Yimei Tang Yanhua Huang Innovative Institute of Animal Healthy Breeding Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong510225China College of Animal Science and Technology Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong510225China Guangzhou Fishtech Biotechnology Co. Ltd.Guangdong510640China

There are a large number of microorganisms in the porcine intestinal tract.These microorganisms and their metabolites contribute to intestinal mucosal immunity,which is of great importance to the health of the host.The host immune system can regulate the distribution and composition of intestinal mi-croorganisms and regulate the homeostasis of intestinal flora by secreting a variety of immune effector factors,such as mucin,secretory immunoglobulin A(sIgA),regenerating islet-derivedⅢ(RegⅢ)γ,and defensin.Conversely,intestinal microorganisms can also promote the differentiation of immune cells including regulatory T cells(Treg)and Th17 cells through their specific components or metabolites.Studies have shown that imbalances in the intestinal flora can lead to bacterial translocation and compromised intestinal barrier function,affecting the health of the body.This review focuses on the composition of the pig intestinal flora and the characteristics of intestinal mucosal immunity,discusses the interaction mechanism between the flora and intestinal mucosal immunity,as well as the regulation through fecal microbiota transplantation(FMT),dietary nutritional composition,probiotics and pre-biotics of pig intestinal microecology.Finally,this review provides insights into the relationship between intestinal microorganisms and the mucosal immune system.

关键词： gut microbe Pig Intestine Mucosal immunity

Dietary fiber and microbiota interaction regulates sow metabolism and reproductive performance

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2020年第4期6卷 397-403页

作者： Min Tian Jiaming Chen Jiaxin Liu Fang Chen Wutai Guan Shihai Zhang Guangdong Province Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou510642China College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou516042China

Dietary fiber is a critical nutrient in sow diet and has attracted interest of animal nutritionists for many years.In addition to increase sows’satiety,dietary fiber has been found to involve in the regulation of multiple biological functions in the sow production.The interaction of dietary fiber and gut microbes can produce bioactive metabolites,which are of great significance to sows’metabolism and reproductive performance.This article reviewed the interaction between dietary fiber and gut microbes in regulating sows’gut microbial diversity,intestinal immune system,lactation,and production performance,with the aim to provide a new strategy for the use of dietary fiber in sow diets.

关键词： Dietary fiber gut microbe Reproductive performance Sow