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Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome:A comprehensive review

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World Journal of Clinical Cases 2023年第19期11卷 4458-4476页

作者： Shiv Vardan Singh Risha Ganguly Kritika Jaiswal Aditya Kumar Yadav Ramesh Kumar Abhay K Pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002Uttar PradeshIndia

Irritable bowel syndrome(IBS)is a chronic functional disorder which alters gastrointestinal(GI)functions,thus leading to compromised health *** of IBS is not fully understood,whereas abnormal gut brain axis(GBA)has been identified as a major etiological *** studies are suggestive for visceral hyper-sensitivity,altered gut motility and dysfunctional autonomous nervous system as the main clinical abnormalities in IBS *** signalling interactions among these abnormalities are derived through various exogenous and endogenous factors,such as microbiota population and diversity,microbial metabolites,dietary uptake,and psychological *** efforts focused to study these interactions including probiotics,antibiotics and fecal transplantations in normal and germfree animals are clearly suggestive for the pivotal role of gut microbiota in IBS ***,neurotransmitters act as communication tools between enteric microbiota and brain functions,where serotonin(5-hydroxytryptamine)plays a key role in pathophysiology of *** regulates GI motility,pain sense and inflammatory responses particular to mucosal and brain *** the absence of a better understanding of various interconnected crosstalks in GBA,more scientific efforts are required in the search of novel and targeted therapies for the management of *** this review,we have summarized the gut microbial composition,interconnected signalling pathways and their regulators,available therapeutics,and the gaps needed to fill for a better management of IBS.

关键词： Irritable bowel syndrome Microbiota gut brain axis Stress Serotonin

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