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Efficacy and Safety of guihuang formula in Treating Type Ⅲ Prostatitis Patients with Dampness-Heat and Blood Stasis Syndrome: A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第10期28卷 879-884页

作者： LIU Sheng-jing DENG Ying-jun ZENG Yin ZHAO Ming GUO Jun GAO Qing-he Department of Andrology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing(100091)China Graduate School of China Academy of Chinese Medical Sciences Beijing(100700)China Department of Andrology Beijing Chinese Medicine Hospital Afﬁliated to Capital Medical UniversityBeijing(100010)China Graduate School Beijing University of Chinese MedicineBeijing(100029)China

Objective: To observe the efficacy and safety of guihuang formula(GHF) in treating patients with type Ⅲ prostatitis and Chinese medicine syndrome of dampness-heat and blood stasis. Methods: Sixty-six type Ⅲ prostatitis patients with dampness-heat and blood stasis syndrome were randomly divided into the treatment group(GHF) and the control group(tamsulosin) using a random number table, with 33 cases each group. The treatment group received GHF twice a day, and the control group received tamsulosin 0.2 mg once daily before bedtime. Patients in both groups received treatment for 6 weeks and was followed up for 2 weeks. The outcomes included the National Institute of Health Chronic Prostatitis Symptom Index(NIH-CPSI) score, Chinese Medicine Symptoms Score(CMSS), expressed prostatic secretions(EPS) and adverse events(AEs). Results: After treatment, the NIH-CPSI total score and domain scores of pain discomfort, urination and quality of life decreased significantly from the baseline in both groups(P0.05). In addition, no serious AEs were observed. Conclusion: GHF is effective in treating type Ⅲ prostatitis patients with dampness-heat and blood stasis syndrome without serious AEs.(Registration No. ChiCTR1900026966)

关键词： typeⅢprostatitis dampness-heat and blood stasis syndrome guihuang formula Chinese medicine randomized controlled trial

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