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Mechanism Analysis of gui jianyu in treating Hypertension complicated with Impaired Glucose Tolerance Based on Network Pharmacology and Molecular Docking

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TMR Modern Herbal Medicine 2022年第2期5卷 20-28页

作者： Ying Chen Shi-Yi Tao Lu Zhou De-Shuang Yang Chong-Xiang Xue Li Huang China and Japan Friendship School of Clinical Medicine Beijing University of Traditional Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Traditional Chinese MedicineBeijing 100029China Department of Integrative Cardiology China Japan Friendship HospitalBeijing 100029China

Objective To explore the mechanism of gui jianyu(Euonymus alatus(Thunb.)Sieb.)in treating hypertension(HT)complicated with impaired glucose tolerance(IGT)based on network pharmacology and molecular docking *** The main chemical components and targets of gui jianyu were obtained from TCMSP *** Swiss Target Prediction platform was used to predict drug-related targets for *** disease targets of HT complicated with IGT were obtained from GenCards,OMIM and DrugBank *** intersection targets of drugs and two diseases were obtained by R and Veen Diagram was *** protein-protein interaction(PPI)network model was constructed in STRING platform and visualized by Cytoscape *** and KEGG analysis on Metascape platform were used to analyse the common *** of main drug components-disease targets-pathways was established with Cytoscape ***,the molecular docking between the core regulatory active components of gui jianyu and the core targets were verified by Autodock *** Eight active components and 357 corresponding targets were obtained.681 HT related targets and 727 IGT related targets,196 disease intersection targets,and 57 gui jianyu targets in the treatment of HT complicated with IGT were confirmed.20 GO and 19 KEGG main pathways were *** docking of 2 key active ingredients with 2 key targets showed that all results scores were less than-5.0 kcal·*** and kaempferol,the key active components,had good binding activity with AKT1 and *** gui jianyu may play a key role in the treatment of HT complicated with IGT by reducing insulin *** work explored the common pathogenesis of HT complicated with IGT,and also provided a reference for further pharmacological research and exploration the efficacy of gui jianyu for HT complicated with IGT.

关键词： Network pharmacology Molecular docking Insulin resistance gui jianyu Hypertension Impaired glucose tolerance

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