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Nutritional status and nutritional therapy in inflammatory bowel diseases

World Journal of Gastroenterology 2009年第21期15卷 2570-2578页

作者： Corina Hartman Rami Eliakim Raanan Shamir Institute of Gastroenterology Nutritionand Liver DiseaseSchneider Children's Medical Center of Israel Institute of Gastroenterology Rambam Health Care CampusRappaport School of MedicineTechnion Institute

Underweight and specific nutrient deficiencies are frequent in adult patients with inflammatory bowel disease(IBD).In addition,a significant number of children with IBD,especially Crohn's disease(CD) have impaired linear *** has an important role in the management of *** adults with CD,enteral nutrition(EN) is effective in inducing clinical remission of IBD,although it is less efficient than *** EN is an established primary therapy for pediatric *** data suggests that EN is as efficient as corticosteroids for induction of *** advantages of nutritional therapy are control of inflammation,mucosal healing,positive benefits to growth and overall nutritional status with minimal adverse *** available evidence suggests that supplementary EN may be effective also for maintenance of remission in *** studies are needed to confirm these ***,EN supplementation could be considered as an alternative or as an adjunct to maintenance drug therapy in *** does not have a primary therapeutic role in ulcerative *** compositions of enteral dietselemental diets or diets containing specific components-were not shown to have any advantage over standard polymeric diets and their place in the treatment of CD or UC need further *** theories suggest that diet may be implicated in the etiology of IBD,however there are no proven dietary approaches to reduce the risk of developing IBD.

关键词： Inflammatory bowel disease Crohn'sdisease Ulcerative colitis Adults Children Malnutrition growth disorders Nutrition therapy

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Prevalence of celiac disease in Iranian children with idiopathic short stature

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World Journal of Gastroenterology 2008年第48期14卷 7376-7380页

作者： Jalal Hashemi Eskandar Hajiani HBB Shahbazin Rahim Masjedizadeh Navab Ghasemi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Division of Endocrinology and Diabetes center Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Golestan Hospital

AIM： To determine the prevalence of celiac disease （CD） in children with idiopathic short stature （ISS） and the diagnostic value of immunoglobulin （Ig） A G antigliadin antibodies （AGA） and transglutaminase （TTG） antibodies for ***： A total of 104 children （49 male, 55 female） with ISS without a specific etiology were studied. Extensive endocrine investigations had shown no abnormalities in any subject. Anthropometric parameters and IgA AGA and IgA TTG antibodies were evaluated in this study group. These antibodies were measured by enzyme-linked immunosorbent assay. All patients were referred for an endoscopic intestinal biopsy. The biopsy samples were classified according to revised Marsh criteria （UEGW 2001）.RESULTS： We detected positive IgA TTG antibodies in 36 and IgA AGA in 35 of these patients. Thirty one IgA TTG antibody positive and 28 IgA AGA positive subjects showed histological abnormalities compatible with celiac disease （33.6%）. Sensitivity, specificity, positive predictive value （PPV） and negative predictive value for IgA AGA were found to be 80%, 88.4%, 77.8% and 89.7%, respectively. Sensitivity, specificity and PPV for IgA TTG antibodies were 88.6%, 94.2% and 88.6%, ***： We conclude that the prevalence of celiac disease is high in patients with ISS and it is important to test all children with ISS for celiac disease by measuring serologic markers and performing an intestinal biopsy.

关键词： Celiac disease growth disorders Transglu-taminases Antibodies Gliadin

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