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Selenium-enriched and ordinary Green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet

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Food Science and Human Wellness 2022年第3期11卷 738-751页

作者： Meirong Wu Xiaobin Wu Jiangxiong Zhu Fanglan Li Xinlin Wei Yuanfeng Wang Development Center of Plant Germplasm Resources College of Life SciencesShanghai Normal UniversityShanghai 200234China Department of Food Science&Technology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China

High-salt diet is well recognized as a risk factor for hypertension,and dietary intervention plays a critical role in the prevention of hypertension.The current study investigated the effects of selenium-enriched Green tea(Se-GT)and ordinary Green tea(GT)on prevention of hypertension of rats induced by high-salt diet,as well as their potential regulatory and mechanism.Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure(BP),activated the phosphoinosmde-3-kinase/protein kinase B(PI3K/Akt)signaling pathway,and regulated the gene expression related to BP,as well as improved the tissue damage like heart,liver,and kidneys.Besides,the key parameters associated with oxidative stress,inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments.Importantly,GT or Se-GT administration adjusted the diversity and composition of the intestinal flora.Moreover,GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria.More specifically,GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides,whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium.Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora,and thus preventing hypertension induced by high-salt diet.

关键词： High-salt diet Hypertension Green tea Selenium-enriched Green tea PI3K/Akt pathway Microbial profile

Effect of digestive enzymes and pH on variation of bioavailability of Green tea during simulated in vitro gastrointestinal digestion

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Food Science and Human Wellness 2022年第3期11卷 669-675页

作者： Wei Qin Sunantha Ketnawa Yukiharu Ogawa Graduate School of Horticulture Chiba University648MatsudoMatsudo 271-8510Japan

To exam ine the effect of digestive attributes such as digestive enzymes and pH on changes in phenolic compound content and antioxidant activity during digestion,the bioavailability of Green tea infusion was investigated using a simulated in vitro gastrointestinal digestion model.The total polyphenol content(TPC)decreased to 65%–70%throughout the mimicked normal digestion(MD)compared to the initial value.The total flavonoid content(TFC)decreased to approximately 25%after starting the gastric stage(pH 1.2);however,it regained to approximately 60%in the intestinal stage(pH 6.8).The mimicked digestive condition without digestive enzymes(WOE),which followed only the pH conditions of MD,showed significantly lower TPC and TFC values than MD.The percentage of antioxidant activity based on the initial values indexed by DPPH,ABTS,and FRAP gradually declined from approximately 60%at the gastric stage to approximately 40%at the final digestion stage.Meanwhile,the percentage of residual MIC was around 50%at the gastric stage.However,it gradually increased at the intestinal stage.The significantly lower antioxidant activity showed for WOE than MD throughout the simulated digestion.This study demonstrated that digestive enzymes and pH play a crucial role in the bioavailability of Green tea infusion.

关键词： Green tea Polyphenols Antioxidant activity Digestive enzyme Bioavailability

Green tea catechins inhibit microglial activation which prevents the development of neurological disorders

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Neural Regeneration Research 2020年第10期15卷 1792-1798页

作者： Tahereh Farkhondeh Ali Mohammad Pourbagher-Shahri Milad Ashrafizadeh Silvia Llorens Folgado Ali Rajabpour-Sanati Mohammad Reza Khazdair Saeed Samarghandian Cardiovascular Diseases Research Center Birjand University of Medical SciencesBirjandIran Faculty of Medicine Birjand University of Medical SciencesBirjandIran Department of Basic Science Faculty of Veterinary MedicineUniversity of TabrizTabrizIran Department of Medical Sciences Faculty of Medicine of AlbaceteCentro Regional de Investigaciones Biomedicas(CRIB)University of Castilla-La ManchaAlbaceteSpain Healthy Ageing Research Center Neyshabur University of Medical SciencesNeyshaburIran Department of Basic Medical Sciences Neyshabur University of Medical SciencesNeyshaburIran

The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders.The over-activated microglia can disturb neuronal function by releasing inflammatory mediators leading to neuronal dysfunctions and death.Thus,inhibition of over-activated microglia may be an effective therapeutic approach for modulating neuroinflammation.Experimental studies have indicated anti-neuroinflammatory effects of flavonoids such as Green tea catechins.The current research was aimed to review the effect of Green tea catechins in inhibiting microglial cells,inflammatory cascades,and subsequent neurological diseases.

关键词： catechins Green tea microglia neuroinflammation neurological disease

Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence

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Food Science and Human Wellness 2022年第4期11卷 765-770页

作者： Klaus W.Lange Katharina M.Lange Yukiko Nakamura Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge worldwide.The symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the disorder.The potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of AD.Numerous mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical studies.However,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are scarce.While epidemiological studies have provided some evidence indicating that Green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these observations.The clinical evidence regarding preventive or therapeutic effects of Green tea and its bioactive components is unsatisfactory.A role of Green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of Green tea.

关键词： Green tea Epigallocatechin gallate Alzheimer’s disease Neurodegeneration Prevention

Assessing the effectiveness of nanoscale zero-valent iron particles produced by Green tea for Cr(VI)-contaminated groundwater remediation

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Journal of Groundwater Science and Engineering 2023年第1期11卷 55-67页

作者： Hui Li Zhan-tao Han Qiang Deng Chun-xiao Ma Xiang-ke Kong Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Key Laboratory of Groundwater Remediation of Hebei Province and China Geological Survey Shijiazhuang 050061China Technical Centre for Soil Agriculture and Rural Ecology and EnvironmentMinistry of Ecology and EnvironmentBeijing 100012China Resource and Environmental College Hebei Geology UniversityShijiazhuang 050031China

Nanoscale zero-valent iron particles(NZVI) produced by using Green tea(GT) extract as a reductant can remove Cr(Ⅵ) from water effectively,which can be utilized in groundwater remediation.In order to define the reaction mechanism and removal effect in the aquifer,in this study,GT-NZVI particles were prepared and measured by some characterization methods to define their surface performance,and then batch and one-dimensional experiments were carried out to reveal the reaction properties of GT-NZVI and Cr(Ⅵ) in groundwater.The results showed that the prepared GT-NZVI particles were regular spherical with a diameter of 10-20 nm,which could disperse in water stably.The main component of GT-NZVI wasα-Fe with superficial polyphenols as a stabilizer.GT-NZVI suspension had good ability to reduce the Cr(Ⅵ) to Cr(Ⅲ) in water.When the concentration of GT-NZVI was 1 g/L,the removal efficiency of Cr(Ⅵ)with an initial concentration of 100 mg/L reached 92.8% in 1 h reaction.In column tests,GT-NZVI passed through the natural sand column successfully with an average outflow percentage of 71.2%.The simulated in-situ reaction zone(IRZ) with GT-NZVI was used to remediate Cr(Ⅵ) contaminated groundwater.The oufflow concentration of Cr(Ⅵ) kept in 0.14-0.32 mg/L corresponding to the outflow rate below 0.32%within 15 days,and the removal efficiency of Cr(Ⅵ) by IRZ with GT-NZVI decreased with the increase of aquifer medium particle size,groundwater flow rate and ionic strength.Most of Cr(Ⅲ) as reduzate was adsorbed or immobilized on the surface or in the lattice of GT-NZVI,which indicated effective immobilization for chromium.

关键词： Nanoscale iron particles Green tea Hexavalent chromium Groundwater remediation

Synergistic effects of three traditional herbs Green tea,mulberry leaf and corn silk on glucose uptake level of L6 myoblasts and the hypoglycemic mechanism

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Traditional Medicine Research 2024年第7期9卷 1-12页

作者： Jing-Na Zhou Ming-Yue Li Ting-Ting Zhang Jing-Yang Lu Min Zhang Peng-Wei Zhuang Hai-Xia Chen Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China. School of Food Science and Bioengineering Tianjin Agricultural UniversityTianjin 300384China. State Key Laboratory of Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China. Haihe Laboratory of Modern Chinese Medicine Chinese Materia Medica CollegeTianjin University of Traditional Chinese MedicineTianjin 301617China.

Background:Green tea,mulberry leaf and corn silk are traditional herbs used in the prevention and treatment of diabetes in China for a long time,but their synergistic hypoglycemic effects and mechanisms remain unclear.Methods:The effective components of Green tea,mulberry leaf and corn silk were extracted and enriched.Mixture design of experiments was used to study the influences of different combinations on the cell viability and glucose uptake level of L6 myoblasts,so as to determine the optimal synergistic hypoglycemic combination.The possible hypoglycemic mechanism of the optimal synergistic combination was explored by cytotoxicity assay,glucose uptake assay,and western blot.Results:Three polyphenol enrichment fractions of the herbs,30%ethanol elution fraction of Green tea(GT),50%ethanol elution fraction of mulberry leaf(ML)and 60%ethanol elution fraction of corn silk(CS)were obtained.The antioxidant activities of GT-30%,ML-50%and CS-60%were superior to those of crude extracts,and showed strong potential inα-amylase andα-glucosidase inhibition activities.The optimal synergistic combination of crude extracts G7(crude extract of Green tea:crude extract of mulberry leaf:crude extract of corn silk=1:5:3),polyphenol enrichment fractions R3(GT-30%:ML-50%:CS-60%=1:7:1)and monomers X2(epigallocatechin gallate:morusin:formononetin=3:1:2)were selected,respectively.G7,R3,and X2 showed promoting effects on the cell viability and glucose uptake of L6 myoblasts within the detected concentration range.In addition,G7,R3,and X2 could increase the expression levels of p-PI3K/PI3K and p-Akt/Akt in L6 myoblasts,and promote the translocation of Glut4,but G7 and R3 showed more significant effects.Conclusion:The synergistic hypoglycemic effects of Green tea,mulberry leaf and corn silk had the characteristics of multiple-components and multiple-targets with p-PI3K/PI3K,p-Akt/Akt and the translocation of Glut4 signal pathways involved.The three traditional herbs might have the potential to be combined used for the prevention and trea

关键词： Green tea mulberry leaf corn silk synergistic effect type 2 diabetes mellitus mechanism

Antioxidant and Antiapoptotic Polyphenols from Green tea Extract Ameliorate CCl4-Induced Acute Liver Injury in Mice

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Chinese Journal of Integrative Medicine 2020年第10期26卷 736-744页

作者： DIAO Jian-xin OU Jin-ying DAI Huan LI Hai-ye HUANG Wei HUA He-yu XIE Ting WANG Ming YANG Yun-gao School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Department of Internal Medicine Yongxing County People’s HospitalChengzhou(423000)Hunan ProvinceChina Department of Traditional Chinese Medicine Zhujiang Hospital of Southern Medical UniversityGuangzhou(510515)China

Objective To investigate the phenolic composition,antioxidant properties,and hepatoprotective mechanisms of polyphenols from Green tea extract(GTP)in carbon tetrachloride(CCl4)-induced acute liver injury mouse model.Methods High-performance liquid chromatography was used to analyze the chemical composition of the extract.Antioxidant activity of GTP was assessed by O2∙-,OH∙,DPPH∙,and ferric-reducing antioxidant power(FRAP)assay in vitro.Sixty Kunming mice were divided into 6 groups including control,model,low-,medium-,and high-doses GTP(200,400,800 mg/kg)and vitamin E(250 mg/kg)groups,10 in each group.GTP and vitamin E were administered at a level of abovementioned doses twice per day for 7 days prior to exposure to a single injection of CCl4.Hepatoprotective effects of GTP were evaluated in a CCl4-induced mouse model of acute liver injury,using commercial enzyme linked immunosorbent assay kits,histopathological observation,terminal deoxynucleotidyl transferase-mediated dUTPNick-end labeling(TUNEL)assay and Western blot.Results GTP contained 98.56µg gallic acid equivalents per milligram extract total polyphenols,including epicatechingallate,epigallocatechin gallate,epicatechin,and epigallocatechin.Compared with the model group,low-,medium-,or high doses GTP significantly decreased serum levels of alanine aminotransferase and aspartate transaminase(P<0.01).Histopathological observation confirmed that pretreatment of GTP prevented swelling and necrosis in CCl4-exposed hepatocytes.Hepatoprotective effects of low-,medium-,and high-dose GTP were associated with eliminating free radicals and improving superoxide dismutase,catalase,and glutathione peroxidase activity in the liver.Additionally,low-,medium-,and high-dose GTP decreased cell apoptosis in the CCl4-exposed liver(P<0.01).Phosphorylated nuclear factor kappa-B(NF-κB),p53,Bcl-2 associated x protein/B-cell lymphoma/leukemia-2 gene,cytochrome C,and cleaved caspase-3 levels were downregulated compared with the model group(P<0.01).Conclusion GTP achieves hepatoprotect

关键词： polyphenol carbon tetrachloride acute liver injury anti-oxidant anti-apoptosis Green tea

Effect of Green tea consumption in treatment of mild to moderate depression in Iranian patients living with HIV: A double-blind randomized clinical trial

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Chinese Herbal Medicines 2021年第1期13卷 136-141页

作者： Dehghan Manshadi Seyed Ali Mousavi Seyed Alireza Salehi Mohammad Reza Zebardast Jayran SeyedAlinaghi SeyedAhmad Rezazade Shams Ali Mirhoseinian Seyed Saeid Asadollahi-Amin Ali Department of Infectious Diseases and Tropical Medicine Imam-Khomeini Hospital ComplexTehran University of Medical SciencesTehranTehran 11519Iran Department of Infectious Diseases and Tropical Medicine Shahid Sadoughi HospitalShahid Sadoughi University of Medical Sciences and Health ServicesYazd 11519Iran Cognitive Neuroscience Linguistics Institute for Cognitive Science Studies(ICSS)Tehran 11519Iran Iranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk BehaviorsTehran University of Medical SciencesTehran 11519Iran Medicinal Plants Research Center Institute of Medicinal PlantsACECRTehran 11519Iran Department of Pharmacognosy Faculty of Pharmacy.Tehran University of Medical Sciences.Tehran 11519Iran

Objective: Depression affects people living with HIV(PLWH) compliance leading to poor control infection.Previous observational studies showed an anti-depression effect of Green tea extract(GTE). The therapeutic effect of GTE on depression were investigated in PLWH receiving antiretroviral therapy(ART).Methods: Fifty PLWH on ART with diagnose of mild to moderate of depression, participated in a doubleblind, placebo-controlled trial and underwent 12 weeks of treatment with either 400 mg GTE capsules or placebo twice daily. The Hamilton depression scale of patients was measured before, 6 weeks and 12 weeks after treatment in two groups. The primary outcome measure was performed to evaluate the efficacy of GTE in improving depressive symptoms.Results: The mean of Hamilton score showed a significant difference between the two groups after 12 weeks(P = 0.035). Repeated measures ANOVA test showed a significant effect for time ? treatment interaction on the Hamilton mean score between the two groups(P = 0.000).Conclusion: It seems the use of GTE capsules in PLWH on ART is safe and could lead to greater and more rapid improvement in depressive symptoms than placebo. Thus it can be considered as an alternative therapy for mild to moderate depression. Further studies with higher sample size and longer followup and comparisons with other antidepressive drugs are warranted.

关键词： depression Green tea HIV

Using endogenous pigments to recolour roasted Green tea

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Food Quality and Safety 2021年第3期5卷 231-238页

作者：朱宏凯张坚强刘飞陈琳叶阳 tea Research Institute China Academy of Agricultural SciencesHangzhouChina Key Laboratory of tea Biology and Resource Utilization Ministry of AgricultureHangzhouChina tea and Fruit Instructional Station of Yixing City YixingChina tea Research Institute of Sichuan Academy of Agricultural Science ChengduChina

Roasted Green tea exhibits undesirable dark green that can seriously affect sensory quality,market price,and consumer acceptance.The aim of this work was to propose a method of improving the appearanee of the roasted Green tea.In this study,rehydration with freeze-drying(RFD)was used to recolour the tea leaves by redistributing the endogenous pigments.The results indicated that the colour of the roasted Green tea changed from dark green to bright green after the RFD treatme nt,the values of L^(*)and b^(*)were significa ntly in creased(Pgreen pigments transfer onto the surface of the tea leaves also induced a change in pigment contents,including chlorophylls,carotenoids,and flavonoid glycosides.The well-defined optimum parameters for the rehydration process were moisture content of tea leaves at 35 per cent,water temperature 25℃,and a standing time of 1.5 h.

关键词： Green tea colour pigments rehydration freeze-drying.