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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses

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Cellular & Molecular Immunology 2021年第8期18卷 1956-1968页

作者： Seon-Hee Kim Rohit Singh Chungyong Han Eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim Dong Hoon Shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi Division of Tumor Immunology National Cancer CenterGoyang10408Republic of Korea Graduate School of Cancer Science and Policy National Cancer CenterGoyang10408Republic of Korea Biomedicine Production Branch Program for Immunotherapy ResearchGoyang10408Republic of Korea Eutilex Institute for Biomedical Research EutilexCo.Ltd.Seoul08594Republic of Korea Division of Convergence Technology National Cancer CenterGoyang10408Republic of Korea Division of Translational Science National Cancer CenterGoyang10408Republic of Korea Institute of Oral Biology School of DentistryGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA70112USA

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor ***,the adverse side effects associated with agonist antibodies have hindered their clinical ***,we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB *** show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1^(+)CD8^(+)T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8^(+)T cells,which was beneficial for suppressing tumor growth in the early phase of anti-4-1BB ***,repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes(TDLNs)of mice due to recruitment and accumulation of macrophages via the CD8^(+)T cell-IFN-γ*** was accompanied by excessive lymph node swelling,which impaired the sequential activation of CD8^(+)T *** data provide insights into the immune-related adverse events of long-term agonist 4-1BB antibody dosing,which should be considered during the clinical development of immunomodulating therapy.

关键词： 4-1BB Costimulation granuloma CD8 lymphocyte Macrophage

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Liver inflammatory pseudotumor or parasitic granuloma?

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World Journal of Gastroenterology 2000年第3期6卷 458-460页

作者： Ji XL Shen MS Yin T Gen Hosp Chinese PLA Dept Pathol Beijing 100853 Peoples R China

INTRODUCTION Liver pseudotumor is a very rare benign *** the first case reported by Pack and Baker in1953,only 40 cases had been reported up to *** diagnostic challenge of hepatic inflammatorypseudotumor is emphasized... 详细信息

关键词： inflammatory pseudotumor parasitic granuloma ascariasis larva liver disease

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granuloma of graphite foreign body in conjunctiva simulates melanoma: a case report and literature review

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 515-517页

作者： Ying-Wei Wang Yan-Ru He Jing Ma Jian Zhou Yan-Nian Hui Hong-Jun Du Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Pathology Xijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

Dear Editor,We present a rare case of conjunctival foreign body granuloma simulating melanoma caused by longterm retained pencil *** pigmented conjunctival mass and eye injury caused by writing instruments are not rare.

关键词： melanoma rare granuloma

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Spatiotemporal mapping of the leprosy granuloma landscape

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Cellular & Molecular Immunology 2022年第5期19卷 558-560页

作者： Marco P.La Manna Francesco Dieli Nadia Caccamo Central Laboratory of Advanced Diagnosis and Biomedical Research(CLADIBIOR) University of PalermoPalermoItaly Department of Biomedicine Neurosciences and Advanced DiagnosisUniversity of PalermoPalermoItaly

Leprosy is a chronic infectious disease of humans caused by Mycobacterium leprae(***)that is prevalent in some countries of Asia,Africa,and South America[1].Leprosy has traditionally been classified into two major types,tuberculoid and *** with tuberculoid leprosy(TLEP)have limited disease with relatively few bacteria in the skin and nerves and can successfully control the infection.

关键词： granuloma nerves landscape

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Foreign body granuloma in the tongue differentiated from tongue cancer:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6247-6253页

作者： Zhen-Hua Jiang Ran Xv Li Xia Department of Otolaryngology-Head and Neck Surgery Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina

BACKGROUND Embedded foreign bodies in the tongue are rarely seen in clinical *** untreated foreign body can cause a granuloma which often presents as an enlarged tongue ***,if foreign body ingestion status is unknown,physical examination and magnetic resonance imaging(MRI)tend to lead to suspicion of tongue cancer,especially in older ***,differential diagnosis of an enlarged tongue mass is important,especially because it is closely related to the choice of treatment *** SUMMARY A 61-year-old woman was admitted to the hospital with pain and noticeable swelling in the tongue that had persisted for over 1 *** had no previous medical *** revealed abnormal signal intensities that were indicative of a ***,the oral surgeon and radiologist arrived at a primary diagnosis of tongue *** patient visited the Ear Nose and Throat Department for further consultation and underwent an ultrasound examination of the *** ultrasonography was consistent with a linear hyperechoic foreign body which was indicative of an embedded foreign body(bone)in the tongue,even though the patient denied any history of foreign body *** surgical enucleation of the lesion was *** mass which included a fish bone was completely *** post-operative pathological examination confirmed that the mass was a granuloma containing collagen fibers,macrophages and chronic inflammatory *** patient recovered without complications over a 2 mo follow-up *** We report a rare case of foreign body granuloma in the tongue that was primarily diagnosed as tongue *** MRI and ultrasound examinations revealed a piece of bone in the left lateral aspect of the *** granuloma,which contained a fish bone,was completely removed via surgery and confirmed via *** diagnosis of the enlarged tongue mass was critical to the selection of treatment method.

关键词： Tongue Foreign body granuloma Cancer Differential diagnosis Case report

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A Retrospective Study on Cholesteatoma Otitis Media Coexisting with Cholesterol granuloma

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第2期22卷 168-170页

作者： LUO Linghui GONG Shusheng BAI Guangping WANG Jibao Department of Otolaryngology Xiehe HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022

To investigate the etiology and pathogenesis of cholesteatoma otitis media accompanied by cholesterol granuloma and the relationship between cholesteatoma and cholesterol granuloma,63 cases of middle ear cholesterol granuloma treated in our hospital during the period from March 1988 to May 2000 were retrospectively *** cases were surgically and pathologically verified.15 cases of cholesteatoma coexisting with cholesterol granuloma were found among the 63 *** 15 cases had a long-term history of otitis media,such as otorrhea(sanguine purulent otorrhea and bloody otorrhea in 8 cases)and perforation of the eardrum(perforation of pars flaccida in 8 cases).Temporal bone CT scans showed cholesteatoma in 11 *** patients were treated surgically,and cholesteatoma and cholesterol granuloma were found coexisting alternately,the latter lying mainly in the tympanic antrum,attic and mastoid air ***-colored mucus was accumulated in well-developed mastoid air cells,and glistening dotty cholesterol crystals were also *** most cases,enlarged aditus,destruction of lateral attic wall,erosion of ossicular chain,exposure of horizontal segment of facial nerve and tegmen of attic were *** of Eustachian tube was noted in 6 cases,and occlusion of tympanic isthmus was revealed in all cases.A post-operative dry ear was achieved in all patients,and hearing improvement was achieved in all 12 cases following *** and cholesterol granuloma in middle ear may share a common pathophysiological etiology:occlusion of ventilation and disturbance of *** diagnosis should be considered when patients presented with chronic otitis media with bloody *** and magnetic resonance imaging are useful for the diagnosis before *** surgical approach depends on the location,extension and severity of the lesion,The purpose of surgery is to remove the lesion and create an adequate drainage.

关键词： cholesteatoma middle ear granuloma surgical procedures

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Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 539-542页

作者： Zhaodi WANG Xuan LU Yunmei YANG Yuanqiang LU DepartmentofGeriatricandEmergency Medicine theFirst Affiliated Hospital.Zhejiang University Schoolof MedicineHangzhou310003 China Key Laboratoryfor Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou310003.China

Epstein-Barr virus(EBV),a double-stranded DNA virus with an envelope,is a ubiquitous pathogen that is prevalent in humans,although most people who contract it do not develop symptoms(Kerr,2019).While the primary cells EBV attacks are epithelial cells and B lymphocytes,its target range expands to a variety of cell types in immunodeficient *** change occurs in 90%of infected ***,immunoglobulin M(IgM)and IgG,serologically reactive to viral capsid antigens,are reliable biomarkers for the detection of acute and chronic EBV infections(Cohen,2000).Symptoms of EBV infection vary according to age and immune status.

关键词： infection acute granuloma

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Giant pyogenic granuloma on the glans penis

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Asian Journal of Urology 2020年第4期7卷 382-383页

作者： Sheetanshu Kumar Tarun Narang Bishan Dass Radotra Dipankar De Department of Dermatology Venereology and LeprologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Histopathology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

A middle aged uncircumcised man presented with a painless growth on the glans penis which started 6 months back as a pinhead sized papule and rapidly progressed in *** patient reported occasional bleeding from the lesion on minimal *** patient was unable to perform sexual intercourse owing to the size of lesion and concern of *** patient was in monogamous relationship with his wife and denied any high risk sexual *** examination,there was a non-tender,oval,dark red,smooth,shiny,exophytic pedunculated growth of size 2.5 cm2 cm0.5 cm on the glans with a small but broad pedicle at the base of the lesion(Fig.1).Histopathological examination of the mucosal biopsy from the lesion revealed lobular proliferation of capillaries with thinned out epithelium(Fig.2).The diagnosis of penile pyogenic granuloma(PG)was reached on the basis of above *** lesion was referred to urology services and the lesion was surgically excised.

关键词： granuloma diagnosis bleeding

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Eosinophilic granuloma of the cervical spine

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Chinese Medical Journal 1997年第10期 79-81页

ＥｏｓｉｎｏｐｈｉｌｉｃｇｒａｎｕｌｏｍａｏｆｔｈｅｃｅｒｖｉｃａｌｓｐｉｎｅＫｅｎｎｅｔｈＭａｎＣｈｅｅＣｈｅｕｎｇ，ＹａｔＷａＷｏｎｇ，ＫｅｉｔｈＤｉｐＫｅｉＬｕｋａｎｄＪｏｈｎＣｈｉＹａｎＬｅｏｎｇＥｏｓｉｎｏ... 详细信息

ＥｏｓｉｎｏｐｈｉｌｉｃｇｒａｎｕｌｏｍａｏｆｔｈｅｃｅｒｖｉｃａｌｓｐｉｎｅＫｅｎｎｅｔｈＭａｎＣｈｅｅＣｈｅｕｎｇ，ＹａｔＷａＷｏｎｇ，ＫｅｉｔｈＤｉｐＫｅｉＬｕｋａｎｄＪｏｈｎＣｈｉＹａｎＬｅｏｎｇＥｏｓｉｎｏｐｈｉｌｉｃｇｒａｎｕｌｏｍａｏｆ...

关键词： the spine granuloma Eosinophilic cervical

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Fungal granuloma of mediastinal lymph nodes in an immunocompetent host

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Chinese Medical Journal 2011年第15期000卷 2396-2399页

作者： CHEN Xue-yuan LI Hui-ping ZHANG Rong-xuan LU Shui-hua Department of Respiratory Diseases Shanghai Pulmonary Hospital Tongji University Shanghai 200433 China Department of Pathology Shanghai Pulmonary Hospital Tongji University Shanghai 200433 China Department of Respiratory Shanghai Public Health Clinical Center affiliated to Fudan University Shanghai 201508 China

This is a case report of mediastinal fungal granuloma in an immunocompetent host. The definite diagnosis was made by pathological biopsy via video-assisted thoracoscopy and silver methenamine staining showed aspergillus hyphae and spores in the epithelioid granuloma. In conclusion, opportunistic pathogenic fungi can cause granulomatous inflammation in mediastinal lymph nodes in an immunocompetent host, as it can do in an immunocompromised host. More attention should be paid on tissue biopsy and pathological examination to ensure a correct diagnosis for these kinds of cases.

关键词： granuloma mediastinum fungi immunocompetent host

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