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Bariatric surgery induces alterations in effective connectivity between the orbitofrontal cortex and limbic regions in obese patients

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Science China(Information Sciences) 2020年第7期63卷 49-59页

作者： Shijun DUAN Gang JI Guanya LI Yang HU Wenchao ZHANG Jia WANG Dardo TOMASI Nora D.VOLKOW Yongzhan NIE Guangbin CUI Gene-Jack WANG Yi ZHANG Department of Radiology Tangdu Hospital Fourth Military Medical University State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University Center for Brain Imaging School of Life Science and Technology Xidian University Laboratory of Neuroimaging National Institute on Alcohol Abuse and Alcoholism

Obese subjects show enhanced brain responses in motivation and reward neurocircuitry encompassing sensory and somatic integration-interception, motivation-reward(striatal), emotion, and memory processes, which attenuate frontal region activation during food cues. Bariatric surgery(BS) is the only reliable treatment for morbid obesity. Unfortunately, it is unknown how BS affects neurocircuitry after weight loss. We aimed to examine effects of BS on the basal activity of brain areas involved in reward and motivation processing, emotion, memory, and gut-brain interaction. We combined resting-state fMRI with amplitude of low-frequency fluctuation(ALFF) and granger causality analysis(GCA) to assess interactions between regions within the frontal-mesolimbic circuitry in 16 obese subjects(OB) and 22 normal-weight(NW) *** OB group was studied at baseline and 1 month post BS. Comparisons between OB and NW, and preand post BS showed significant differences in ALFF in areas involved in drive(caudate, orbitofrontal cortex(OFC)), arousal(thalamus), and conditioning/memory(amygdala, hippocampus)(P < 0.05, FDR correction). GCA revealed that in the OB group, the OFC had greater connectivity to limbic regions(amygdala,hippocampus, and medial thalamus) and the caudate. Post BS, the connectivity of the OFC to limbic regions decreased, whereas the connectivity from the amygdala and hippocampus to the caudate and thalamus was enhanced, particularly in subjects with lower body mass index(BMI). OFC activation in the OB group was associated with BMI prior to surgery, and changes in OFC post surgery were associated with alterations in BMI. Overall, the functional connectivity of the OFC was significantly decreased. As it is important for salience attribution and connected to limbic brain regions involved with emotional reactivity and conditioning after BS, its significant association with BMI changes indicates the contribution of OFC changes to the improved control of eating behavi

关键词： fMRI granger causality analysis obesity bariatric surgery frontal-mesolimbic

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Regional Financial Development and Regional Economic Growth: An Empirical analysis of Suzhou City, China

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Chinese Geographical Science 2010年第3期20卷 269-274页

作者： LIU Yong LI Weiping Economics School Peking University Beijing 100871 China China Development Bank Beijing 100037 China

There are many defects in researches on the relationship of the regional financial development (FD) and economic growth of China, such as simply assuming the causality direction, not highlighting financial institution, using incomplete financial indicator, etc. This article, taking Suzhou City of Jiangsu Province, China as a case, builds a simple model to study the level of FD from three aspects of financial scale, structure and institution. Three original indicators of PRIVY (private investment/aggregate investment), DEPTH (aggregate loan/GDP) and FDIVG (FDI/GDP) are used to construct the FD economic indicator through Principal Component analysis approach. Then we use granger method to analyze the relationship between the FD and the economic growth of Suzhou. Empirical test results show that the FD of Suzhou is the granger reason of economic growth, while economic growth is not the reason for FD, because the relationship between the FD and the economic growth of Suzhou is just in the ″supply-leading″ period. In terms of Suzhou experiences, the local government should strengthen the protection of private investment, improve the institutional environment, and establish the reasonable financial structure. So we can concluded that FD could play a great role in promoting economic growth at the economy takeoff stage.

关键词： financial development regional economic growth institution granger causality analysis

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Study on the Relationship Between the Chemical Industry Energy Consumption and Economic Development in China

Study on the Relationship Between the Chemical Industry Ener...

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2012年管理与服务科学国际会议(MASS2012)

作者： Li Xinran Fan Tijun Zhang Lili Statistics and Management School Shanghai University of Finance and Economics Business School East China University of Science and Technology

the chemical industry is the pillar industry of national economy, but also features in high energy consumption and high emission. Based on the cointegration analysis and causality method, this paper empirically researches the relationship between China chemical industry energy consumption and economic growth from 1996 to 2007. It finds that there exists a long-term cointegration relationship between the chemical industry energy consumption and economic development. At the same time, the chemical industry development will lead to energy consumption, but the converse is not true. The results show that to promote healthy and sustainable development of chemical industry in China, it is necessary to ensure adequate energy supply, but also constantly improve energy efficiency and adjust the energy structure.

关键词： chemical industry energy consumption granger causality analysis

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Operating Performance Assessment and Cause Identification of Sewage Treatment Process

Operating Performance Assessment and Cause Identification of...

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第32届中国过程控制会议(CPCC2021)

作者： Yuhan Wang Xin Peng Hui Cheng Weimin Zhong Key Laboratory of Smart Manufacturing in Energy Chemical Process East China University of Science and Technology

A good and stable running state is the guarantee of high product quality of an industrial process and the premise of the maximization of enterprise *** decades have witnessed the constant improvement of process detection *** of the safety of production process,keeping the production process in good working condition has become the new research ***,it is necessary to identification the root cause when the production state enters into non-optimization,so as to adjust the production *** this paper,a novel operating performance assessment and cause identification method is *** correlation analysis and slow feature analysis are used for state assessment,and based on the result,nonoptimal cause identification was performed using granger causality analysis and Bayesian network *** effectiveness is validated by BSM1.

关键词： process performance assessment non-optimal cause identification granger causality analysis Bayesian network

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