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Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer

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Nano Research 2023年第7期16卷 9688-9700页

作者： Pengyuan Liu Yajun Wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang Piao Zhibing Wu Department of Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Radiation Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Geriatrics Institute of Zhejiang Province Department of GeriatricsAffiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310030China Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhou 310058China TCM Dispensary Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Department of Breast Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China

Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat effectively.Exploring treatment options that can accurately target CPRC is an important issue with urgent need.In this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of CRPC.By combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic effects.From nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and chemotherapy.Doxorubicin(DOX)was selected as the chemotherapeutic agent for cytotoxicity.In terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug delivery.The nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)irradiation.Through the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in vitro.This work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision.

关键词： castration-resistant prostate cancer gold nanocage heat shock protein 70 targeted drug delivery photothermalchemotherapy

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gold nanocages in cancer diagnosis,therapy,and theranostics:A brief review

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Frontiers of Materials Science 2021年第4期15卷 494-511页

作者： Vahid ALIMARDANI Ghazal FARAHAVAR Sepide SALEHI Saeed TAGHIZADEH Moosa Rahimi GHIASI Samira Sadat ABOLMAALI Department of Pharmaceutical Nanotechnology School of PharmacyShiraz University of Medical SciencesShirazIran Department of Medical Biotechnology School of Advanced Medical Sciences and TechnologiesShiraz University of Medical SciencesShirazIran Laboratory of Basic Sciences Mohammad Rasul Allah Research TowerShiraz University of Medical SciencesShirazIran Center for Nanotechnology in Drug Delivery Shiraz University of Medical SciencesShirazIran

Regarding the increasing number of cancer patients,the global burden of this disease is continuing to grow.Despite a considerable improvement in the diagnosis and treatment of various types of cancer,new diagnosis and treatment strategies are required.Nanotechnology,as an interesting and advanced field in medicine,is aimed to further advance both cancer diagnosis and treatment.gold nanocages(AuNCs),with hollow interiors and porous walls,have received a great deal of interest in various biomedical applications such as diagnosis,imaging,drug delivery,and hyperthermia therapy due to their special physicochemical characteristics including the porous structure and surface functionalization as well as optical and photothermal properties.This review is focused on recent developments in therapeutic and diagnostic and applications of AuNCs with an emphasis on their theranostic applications in cancer diseases.

关键词： gold nanocage cancer nanotechnology imaging theranostics drug delivery

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Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis

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Nano-Micro Letters 2021年第2期13卷 124-143页

作者： Qin Zhao Miusi Shi Chengcheng Yin Zifan Zhao Jinglun Zhang Jinyang Wang Kailun Shen Lingling Zhang Hua Tang Yin Xiao Yufeng Zhang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of StomatologyWuhan UniversityWuhan 430079People’s Republic of China Medical Research Institute School of MedicineWuhan UniversityWuhan 430071People’s Republic of China Institute of Immunology Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000People’s Republic of China Institute of Health and Biomedical Innovation&Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of TechnologyKelvin Grove 4059QLDAustralia

The immune response of a biomaterial determines its osteoinductive effect.Although the mechanisms by which some immune cells promote regeneration have been revealed,the biomaterial-induced immune response is a dynamic process involving multiple cells.Currently,it is challenging to accurately regulate the innate and adaptive immune responses to promote osteoinduction in biomaterials.Herein,we investigated the roles of macrophages and dendritic cells(DCs)during the osteoinduction of biphasic calcium phosphate(BCP)scaffolds.We found that osteoinductive BCP directed M2 macrophage polarization and inhibited DC maturation,resulting in low T cell response and efficient osteogenesis.Accordingly,a dual-targeting nano-in-micro scaffold(BCP loaded with gold nanocage,BCP-GNC)was designed to regulate the immune responses of macrophages and DCs.Through a dual-wavelength photosensitive switch,BCP-GNC releases interleukin-4 in the early stage of osteoinduction to target M2 macrophages and then releases dexamethasone in the later stage to target immature DCs,creating a desirable inflammatory environment for osteogenesis.This study demonstrates that biomaterials developed to have specific regulatory capacities for immune cells can be used to control the early inflammatory responses of implanted materials and induce osteogenesis.

关键词： gold nanocage Drug release Photocatalysis Immunomodulation Osteoinduction

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gold nanocages as multifunctional materials for nanomedicine

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Frontiers of physics 2014年第3期9卷 378-384页

作者： Xiaohu Xia The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Medical School Atlanta GA 30332 USA School of Chemistry and Biochemistry School of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta GA 30332 USA

Featured by tunable localized surface plasmon resonance peaks in the near-infrared region and hollow interiors, Au nanocages represent a novel class of multifunctional nanomat, erials that have gained considerable attention in recent vears. This short review summarizes our recent work on the capabilities of An nanocages in nanomedicine. We start with a brief description of the synthesis of Au nanocages and highlight our recent protocols for the scaled-up production of An na.nocages. We then use a numer of examples to illustrate how Au nanocages can contribute to nanomedicine with respect to both diagnosis and therapy.

关键词： gold nanocage nanomedicine diagnosis therapy

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