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Validamycin treatment significantly inhibits the glycometabolism and chitin synthesis in the common cutworm,Spodoptera litura

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Insect Science 2022年第3期29卷 840-854页

作者： Hai-Zhong Yu Qin Zhang Zhan-Jun Lu Ming-Jie Deng College of Life Sciences Gannan Normal UniversityGanzhouJiangxi ProvinceChina National Navel Orange Engineering Research Center GanzhouJiangxi ProvinceChina Analytical and Testing Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Validamycin,as a broadly applied antibiotic,has been used to control rice sheath blight ***,validamycin was considered as an insecticide to control agricultural *** into the mechanism of validamycin’s action on insects can provide molecular targets for the control of agricultural *** this study,a toxicological test analysis revealed that Spodoptera litura larval growth and development was significantly inhibited and the pupation rate was significantly reduced with the increase of the concentration of *** to the NMR-based metabolomic analysis,a total of 15 metabolites involved in glycolysis and tricarboxylic acid cycle(TCA)pathways were ***,trehalase activities,glucose and chitin contents were significantly downregulated,but the trehalose content was upregulated after exposure to *** transcription quantitative PCR analysis revealed that the expression level of genes involved in glycolysis,TCA and chitin synthesis were upregulated after treating with *** chitin staining also confirmed that chitin content was downregulated at 12 h after validamycin *** results indicated that validamycin worked via two different molecular mechanisms,one through inhibiting glycometabolism and the other by inhibiting chitin synthesis in *** information lays a theoretical foundation for further control of ***.

关键词： chitin synthesis glycometabolism ^(1)H-NMR metabonomics Spodoptera litura validamycin

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Liver-specific Reduction of Mfn2 Protein by RNAi Results in Impaired glycometabolism and Lipid Homeostasis in BALB/c Mice

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第6期29卷 689-696页

作者：陈小琳徐焱成 Department of Endocrinology Renmin Hospital of Wuhan University Department of Endocrinology Zhongnan Hospital of Wuhan University

Mitofusin-2 （Mfn2） gene expression is positively correlated with insulin sensitivity in patients with type 2 diabetes. However, it is unclear if Mfn2 is involved in carbohydrate metabolism and lipid homeostasis. In order to investigate the specific functions of Mfn2 in glycometabolism and lipid homeostasis in BALB/c mice, a RNA interference technique-mediated hydrodynamic injection was developed, in which short hairpin RNAs （shRNAs） were used to inhibit the Mfn2 expression in vivo. Seventy-two mice were randomly divided into two groups： the Mfn2 reduction group （Mfn2/shRNA） and the negative control group （NC）. Intraperitoneal glucose tolerance tests and intraperitoneal insulin tolerance tests were used to evaluate glycometabolism and insulin sensitivity. D-（3-3H） glucose or 3H2O was injected into the tail vein or intraperitoneally to facilitate the calculation of the rate of hepatic glucose production and fatty acid synthesis in vivo. The results showed that, in Mfn2/shRNA mice, the liver Mfn2 protein was significantly decreased, and fasting blood glucose concentrations were increased by approximately 48%, when compared with the NC mice. In parallel with the changes in fasting glucose levels, hepatic glucose production was significantly elevated in Mfn2/shRNA mice. When insulin was administrated, these mice exhibited impaired insulin tolerance. It was also found that the reduction of Mfn2 markedly decreased the rate of fatty acid synthesis in the liver, and the Mfn2/shRNA mice exhibited hypertriglyceridema. Taken together, our results indicate that Mfn2 plays an important role in maintaining glucose and lipid homeostasis, and in the development of insulin resistance in vivo.

关键词： Mitofusin-2 RNA interference glycometabolism lipid homeostasis

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Effects of electroacupuncture on glycometabolism in metabolism syndrome

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World Journal of Acupuncture-Moxibustion 2014年第1期24卷 1-5页

作者：李青李莲罗亚萍周琰秦秀娟冯媛媛米慧茹张炜冉宋敬坤邢海娇姚美美王少锦石家庄市第一医院河北中医学院

Objec ve To observe the effi cacy of electroacupuncture on glycometabolism disturbance in metabolism syndrome. Methods With matched-pairs design,80 pa ents mee ng with the diagnos c criteria for glycometabolism abnormali es were randomized into the group combining acupuncture and medica on（group A） and the western medicine group（group B）,and 40 pa ents were included in each group. Electroacupuncture was carried out on back-shu points,Zúsānlǐ（足三里 ST 36）,Zhōngwǎn（中脘 CV 12）,Sānyīnjiāo（三阴交 SP 6） and other acupoints for group A,needles were retained for 20 min except back-shu points,once a day,con nuous ten mes as a treatment course,the next treatment course was started a er an interval for 3–5 days,and totally 3 treatment courses were carried out; furthermore,the pa ents were orally administered with Glucotrol XL and felodipine,5 mg each,once a day. The pa ents in group B were treated simply with drugs（the medica on was the same to that for the group A）. Body mass index（BMI）,related biochemical indices and blood pressure of the pa ents were measured before and a er the interven on,respec vely. Results BMI,blood-fas ng glucose,blood glucose 2 h after meal,fasting insulin,insulin resistance index,systolic pressure and diastolic pressure in group A all significantly improved in comparison to those before the electroacupuncture intervention（P0.01）. The difference in BMI in group B before and after the treatments was not statistically significant（P0.05）,and other indices all showed significant improvements（P0.01）. The improvements in the indices as mentioned above in the group A after treatment were significantly better than those in the group B（P0.01）. Conclusion Electroacupuncture intervention can significantly reduce weight,combina on of acupuncture and medica on shows be er effi cacy in reducing blood glucose,improving insulin sensi vity and insulin resistance in comparison to simple administra on with medica ons.

关键词： metabolic syndrome glycometabolism insulin resistance electroacupuncture combina on of acupuncture and medica on

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Basal physiological parameters in domesticated tree shrews(Tupaia belangeri chinensis)

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Zoological Research 2013年第2期34卷 69-74页

作者： Jing WANG Xin-Li XU Ze-Yang DING Rong-Rong MAO Qi-Xin ZHOU Long-Bao LV Li-Ping WANG Shuang WANG Chen ZHANG Lin XU Yue-Xiong YANG Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and MemoryKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences Anhui UniversityHefei 230601China Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghai 200030China Tree Shrew Inbreeding Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Establishing non-human primate models of human diseases is an efficient way to narrow the large gap between basic studies and translational *** advantages such as simplicity of breeding,low cost of feeding and facility of operating make the tree shrew an ideal non-human primate model *** features like vulnerability to stress and spontaneous diabetic characteristics also indicate that the tree shrew could be a potential new animal model of human ***,basal physiological indexes of tree shrew,especially those related to human disease,have not been systematically ***,we established important basal physiological indexes of domesticated tree shrews including several factors:(1)body weight,(2)core body temperature and rhythm,(3)diet metabolism,(4)locomotor rhythm,(5)electroencephalogram,(6)glycometabolism and(7)serum and urinary hormone level and urinary cortisol *** compared the physiological parameters of domesticated tree shrew with that of rats and *** showed that(a)the core body temperature of the tree shrew was 39.59±0.05°C,which was higher than that of rats and macaques;(b)Compared with wild tree shrews,with two activity peaks,domesticated tree shrews had only one activity peak from 17:30 to 19:30;(c)Compared with rats,tree shrews had poor carbohydrate metabolism ability;and(d)Urinary cortisol rhythm indicated there were two peaks at 8:00 and 17:00 in domesticated tree shrews,which matched activity peaks in wild tree *** results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrews.

关键词： Domesticated tree shrew Basal physiological indexes Rhythm glycometabolism Stress-related hormone

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Effects of bis（ a-furancarboxylato）oxovanadium（Ⅳ） on type 2 diabetic rats

Effects of bis（ a-furancarboxylato）oxovanadium（Ⅳ） on ty...

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第十五届国际药理学大会

作者： Niu yanfen Li yanrong Ma yanlin Gao lihui Liu weiping Li ling.Yunnan Pharmacological Laboratories of Natural products Kunming Medical College Kunming PR China. Kunming Institute of Precious Metals Kunming PR China.

＜正＞ Aim: To study the effects and mechanism of bis（ a - furancarboxylato）oxovanadi-um（Ⅳ）（ BFOV） on glucose and lipid metabolism in type 2 diabetic rats. Method: Type 2 diabetic rat was induced by high fat and sucrose feeding + STZ injection. Given i.g. BFOV for 4 weeks, blood glucose. OGTT. serum insulin, and associated parameters were measured;hepatic glycogen. activities of HK and PK and phosphoenolpyravate carboxykinase（ PEPCK） mRNA in liver were determined . Result: The type 2 diabetic rats have been established, with hyperglycemi-a. hyperinsulinemia. hypertriglyceridemia and high level of FFA. BFOV reduced the blood glucose, but did not improve OGTT of diabetic rats. BFOV reduced serum TG and FFA. increased hepatic glycogen and the activities of HK and PK. and decreased PEPCK mRNA of liver in diabetic rats. BFOV had no effect on liver and kidney function. Conclusion: BFOV has antidiabetic effect in type 2 diabetic rats, which mechanism was related to increase hepatic glycogen and decrease gluconeogenesis.

关键词： bis(α-furancarboxylato)oxovanadium(Ⅳ) rat glycometabolism lipid metabolism

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