检索结果-南通市图书馆

The Influence of Remote Ischemic Conditioning on Focal Brain Ischemia in Rats

Journal of Behavioral and Brain Science 2021年第6期11卷 131-142页

作者： Maria E. Kolpakova Anastasia A. Yakovleva Ludmila S. Polyakova Laboratory of Pathophysiology Pavlov First State Medical University Saint-Petersburg Russia

Despite obvious progress in the treatment of acute forms of ischemic stroke, the risk of this condition remains unacceptably high. Brain infarction in the middle cerebral artery basin occurs in patients with atherosclerosis. The onset of the brain infarction is facilitated by the cessation of circulation (embolism) in conditions of insufficient collateral circulation. The extent of the infarct zone is determined by neuronal death and impaired microcirculation. The development of new methods for effective targeted restorative stroke therapy is crucial for restorative treatment and reducing the risk of mortality after stroke. Remote ischemic conditioning (RIC) is an approach to limiting reperfusion injury in the ischemic region of the brain after focal ischemia. One of the most commonly used in vivo models in stroke studies is the filament model of Middle Cerebral Artery Occlusion (MCAO) in rats. In our experiment, it was performed for 30 min (J. Koizumi) with subsequent 48-hour reperfusion. Within the first 24 hours after the start of reperfusion several short episodes of ischemia in low limbs were induced. After 48 hours of reperfusion the brains were harvested and stained with TTC. Then we evaluated the effect of RIC within 24 hours ex vivo in rats’ brains, as well as syndecan-1 plasma concentration. Infarct area was assessed by means of Image-Pro program with statistical analysis. Infarct volumes in the model group (31.97% ± 2.5%) were significantly higher compared to the values in the RIC group 48 hours after ischemia-reperfusion (13.6% ± 1.3%) (*P glycocalyx protein, might be the regulator w

关键词： Stroke Brain Infarction Ischemia-Reperfusion Syndecan-1 glycocalyx Endothelial Dysfunction Middle Cerebral Artery Occlusion (MCAO) Remote Ischemic Conditioning (RIC)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction reduction of glycocalyx of human endothelial cells cultured on anionic hydrogel scaffolds

Friction reduction of glycocalyx of human endothelial cells ...

引用

2007年全国高分子学术论文报告会

作者：陈咏梅龚建萍 Takayuki Kurokawa Masaru Tanaka Yasuda Kazunori Sadaaki Yamamoto Masatsugu Shimomura Yoshihito Osada Graduate School of Science Hokkaido University Sapporo 060-0810Japan Creative Research Initiative’SOUSEI’Hokkaido UniversitySapporo 001-0021 Graduate School of Science Hokkaido University Sapporo 060-0810Japan Graduate School of Science Hokkaido University Sapporo 060-0810Japan Nanotechnology Research Center Research Institute for Electronic Science Hokkaido UniversitySapporo001-0021Japan Creative Research Initiative’SOUSEI’ Hokkaido University Sapporo 001-0021 School of MedicineHokkaido UniversitySapporo 060-0810Japan Creative Research Initiative’SOUSEI’ Hokkaido University Sapporo 001-0021 Nanotechnology Research Center Research Institute for Electronic Science Hokkaido UniversitySapporo001-0021Japan Graduate School of Science Hokkaido University Sapporo 060-0810Japan

＜正＞In the in vivo vascular system,the inner surface of blood vessel is covered by a monolayer of endothelial cell（EC）that exposes to the blood flow.With great interesting, the red blood cells can deform and smoothly squeeze though the capillary of a diameter much smaller.In this process,the friction should occur between soft ECs and deformable blood red cells.Apparently,only when the surface friction between the inner surface wall of

关键词： hydrogel cell culture glycocalyx friction platelet adhesion

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

人红细胞表面电荷的动电学理论——Levine理论的补充

引用

河南医科大学学报 1988年第2期 139-142页

作者：武相义河南医科大学医用物理学教研室

本文介绍了Levine的理论。在Levine所得到的迁移率公式中有一间断点。该间断点恰在所选定的离子强度范围内（C=0.05～0.15M）。为消除此间断点,本文提出glycocalyx层的厚度β与离子强度C的关系式β=β。[1+exp（-c-c?/α）]。为了便于运... 详细信息

本文介绍了Levine的理论。在Levine所得到的迁移率公式中有一间断点。该间断点恰在所选定的离子强度范围内（C=0.05～0.15M）。为消除此间断点,本文提出glycocalyx层的厚度β与离子强度C的关系式β=β。[1+exp（-c-c?/α）]。为了便于运算,本文对Levine公式进行简化,得出一个较简单的迁移率公式。

关键词：迁移率红细胞 glycocalyx 表面电荷

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Proteomic analysis of differential protein expression in Acidithiobacillu ferrooxidans cultivated in high-density potassiumion

Proteomic analysis of differential protein expression in Aci...

引用

福建省海洋学会2012年学术年会

作者： Bo Li Jianping Ouyang Wenbin Guo Xinhua Chen Key Laboratory of Marine Biogenetic Resources Third Institute of OceanographyState Oceanic Administration Key Laboratory of M arine Biogenetic Resources Third Institute of OceanographyState Oceanic Administration

Acidithiobacillus ferrooxidans is a chemolithoautotrophic acidophile that oxidizes ferrous iron or sulfur compounds to obtain energy in the presence of various ions.To investigate the potassium ion adaptability of A.ferrooxidans,we conducted a proteomics analysis.We identified eight proteins that were differentially expressedin the presence of high-density potassium,including four up-regulated and four down-regulated proteins.Transcription levels of the genes encoding differential expressed proteins were subsequently analyzed by Northern blot in the presence of high-density potassium.Among up-regulated proteins,GDP-mannose 4,6-dehydratase,ribose 5-phosphate isomerase A and ribose-phosphate pyrophosphokinase were known to be implicated in the synthesis of glycocalyx,suggesting that the formation of glycocalyx might be involved in the resistence of A.ferrooxidans to high-density potassium ion.In the down-regulated proteins,ATP synthase F1 delta subunit and ATP synthase F1 beta subunit were two important components of ATP synthase.Their down-regulated expression in the presence of high-density potassium suggested that the synthesis of ATP synthase was affected by high-density potassium ion.Therefore,the results obtained here provide some new clues to improve our understanding of the adaptability of A.ferrooxidans to high-density potassium ion.

关键词： Ac idithiobac illus ferrooxidans potassium ion adaptability two-dimensional electrophoresis glycocalyx ATP synthase

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：