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IMMUNOPOTENTIATING POLYSACCHARIDES OF ACANTHOPANAX SENTICOSUS (*** MAXIM.) HARMS

Chinese Science Bulletin 1983年第6期28卷 835-837页

作者：徐任生冯胜初范芝芸叶淳渠翟世康沈美玲 Shanghai Institute of Materia Medica Academia Sinica

Acanthopanax senticosus (Rupr. et Maxim.) Harms or Eleutherococcus senticosus Maxim (Araliaceae) is a small tree and is widely distributed in the northeast area of our country. The roots of this plant are commonly used in Chinese traditional medicine as tonics as well as sedative agent and was named Ci Wu Jia. It is described in Chinese classical pharmacopeia Ben-Cao-Gnag-Mu for the treatment of rheumatoid arthritis and weakness. Soviet scientists have reported the isolation of several glyco-

关键词： Araliaceae Acanthopanax weakness isolation northeast glyco roots residues removed separated

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土豆中配糖碱的测定(综述)

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中国食品卫生杂志 1989年第2期1卷 52-57页

作者：刘昭清徐晋康卫生部食品卫生监督检验所

在土豆中存在的主要配糖碱(glyco-alkaloid)有α—茄碱(α—solanine)和α—卡茄碱(α—Chaconine)及其代谢物(图1),其中前二者占95～99%。配糖碱具有特殊的苦味,其含量与土豆品种,栽培条件及收获后处理与贮存有关,而且,物理或化学的代... 详细信息

在土豆中存在的主要配糖碱(glyco-alkaloid)有α—茄碱(α—solanine)和α—卡茄碱(α—Chaconine)及其代谢物(图1),其中前二者占95～99%。配糖碱具有特殊的苦味,其含量与土豆品种,栽培条件及收获后处理与贮存有关,而且,物理或化学的代射抑制、光照射等都可能产生配糖碱。这些配糖碱具有急性毒性和可能的慢性毒性,现普遍认为。

关键词：茄碱慢性毒性 alkaloid glyco 急性毒性降解产物血清白蛋白亚硫酸钠水提取高压液相色谱法

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Regulation of the cell fate by DNA damage and hypoxia

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World Journal of Medical Genetics 2013年第4期3卷 34-40页

作者： Ramkumar Rajendran Marija Krstic-Demonacos Constantinos Demonacos International Medical University Bukit JalilKuala Lumpur 57000Malaysia School of Environment and Life Sciences College of Science and TechnologyCockcroft BuildingUniversity of SalfordManchester M5 4WTUnited Kingdom Molecular Pharmacology and Cancer Biology Faculty of Medical and Human SciencesManchester Pharmacy SchoolUniversity of ManchesterManchester M139PTUnited Kingdom

In order to provide the means for the design of novel rational anti-cancer drug therapies research efforts are concentrated on unravelling the molecular circuits which induce programmed cell death and block proliferation of cancer *** therapeutic strategies are based on the understanding of the complexity of physiological functions such as differentiation,development,immune responses,cell-cycle arrest,DNA damage repair,apoptosis,autophagy,energy metabolism,and *** has become evident that this knowledge will provide the means to target the components of the pathways involved in these processes in a specific and selective manner thus paving the way for the development of effective and personalised anti-cancer *** is a crucial cellular process that regulates a multitude of physiological functions,which are essential in disease progression and cellular response to *** factors such as the p53 tumor suppressor and the hypoxia-inducible factor-α(HIF-α) are key players in carcinogenesis and cellular response to cancer *** of these transcription factors regulate gene expression of genes involved in cell death and proliferation,in some cases cooperating towards producing the same outcome and in some others mediating opposing *** is thus apparent that fine tuning of the activity of these transcription factors is essential to determine the cellular response to therapeutic regimens,in other words whether tumor cells will commit to apoptosis or evade engagement with the anti-proliferative effects of drugs leading to drug *** observations support the notion that the functional crosstalk between HIF-1α and p53 pathways and thus the fine tuning of their transcriptional activity is mediated by cofactors shared between the two transcription factors such as components of the p300 co-activator multiprotein *** particular,there is evidence to suggest that differential composition of the co-modula

关键词： Cancer Transcription Apoptosis Inflammation Tumor energy metabolism glyco lysis Oxidati ve phos phorylatio n p53 Hypoxia-i nduci ble facto r p300/CBP associated factors

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