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Effect of the glyceryl monooleate-based lyotropic phases on skin permeation using in vitro diffusion and skin imaging

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Asian Journal of Pharmaceutical Sciences 2014年第6期9卷 324-329页

作者： Dae Gon Lim Won-Wook Jeong Nam Ah Kim Jun Yeul Lim Seol-Hoon Lee Woo Sun Shim Nae-Gyu Kang Seong Hoon Jeong College of Pharmacy Dongguk University-SeoulGoyangGyeonggi 410-820Republic of Korea LG Household&Health Care Daejeon 305-343Republic of Korea

glyceryl monooleate(GMO)is a polar lipid that can exist in various liquid crystalline phases in the presence of different amounts of *** is regarded as a permeation enhancer due to its amphiphilic *** phases of GMO/solvent system containing sodium fluorescein were prepared to compare permeability using confocal laser scanning microscopy(CLSM).GMO was melted in a vial in a water bath heated to 45℃.Propylene glycol and hexanediol were homogeneously dissolved in the melted *** fluorescein in aqueous solution was diluted to various ratios and thoroughly mixed by an ultrasonic *** GMO/Solvent system with fluorescein was applied onto the epidermal side of excised pig skin and incubated *** was performed to observe how the GMO/solvent system in its different phases affect skin *** and lamellar phase formulations enhanced the fluorescein permeation through the stratum corneum.A solution system had the weakest permeability compared to the other two *** to the amphiphilic nature of GMO,cubic and lamellar phases might reduce the barrier function of stratum corneum which was observed by CLSM as fluorescein accumulated in the *** on the results,the glyceryl monooleate lyotropic mixtures could be applied to enhance skin permeation in various topical and transdermal formulations.

关键词： Confocal microscopy Imaging glyceryl monooleate Skin permeation Cubic phase Lamellar phase

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