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glycerin monostearate Aggravates Male Reproductive Toxicity Caused by Di(2-ethylhexyl)Phthalate in Rats

Current Medical Science 2019年第6期39卷 1003-1008页

作者： Hai-tao GAO Hong-yi SHI Qi-meng DAI An-qi LI Liu YANG Yue SUN Si-yi JIN Ling-zi XIA Department of Preventive Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035China

Human beings are increasingly exposed to phthalates,which are a group of chemicals used to make plastics more flexible and harder to break,and simultaneously ingesting abundant food emulsifiers via daily *** purpose of this study was to investigate the effect of the food emulsifier glycerin monostearate(GMS)on male reproductive toxicity caused by di(2-ethylhexyl)phthalate(DEHP,one of the phthalates)and explore the underlying *** male Sprague-Dawley rats were randomly divided into control group,DEHP group and DEHP+GMS *** in the DEHP group and DEHP+GMS group were orally administered with 200 mg/kg/d DEHP with or without 20 mg/kg/d *** 30 days of continuous intervention,it was found that the serum testosterone level was significantly lowered in DEHP group and DEHP+GMS group than that in control group(P<0.01).The serum testosterone level and the relative testis weight were significantly decreased in the DEHP+GMS group as compared with those in the DEHP group and control group(P<0.05).More spermatids were observed to be shed off in DEHP+GMS group than in DEHP *** expression levels of cell cycle checkpoint kinase 1(Chkl),cell division cycle gene 2(Cdc2),and cyclin-dependent kinase 2(CDK2)were down-regulated in DEHP group,and this tendency was more significant in DEHP+GMS group(P<0.05 or P<0.01).There was no significant difference in the P-glycoprotein(P-gp)expression between DEHP group and control ***,P-gp was markedly down-regulated in DEHP+GMS group(P<***).The results indicated that the food emulsifier GMS aggravated the toxicity of DEHP on male reproduction by inhibiting the cell cycle of testicular cells and the expression of P-gp in testis tissues.

关键词： glycerin monostearate di(2-ethylhexyl)phthalate reproductive toxicity cell cycle P-glycoprotein

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Food emulsifier glycerin monostearate aggravates phthalates'testicular toxicity by disrupting tight junctions'barrier function in rats

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Food Quality and Safety 2021年第2期5卷 179-187页

作者： Lingzi Xia Min Yang Miao He Mingzhe Jiang Chang Qin Zhijun Wei Haitao Gao Department of Preventive Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina

Objectives:This study aimed to investigate the effect of the widely used food emulsifier glycerin monostearate(GM)on testicular toxicity caused by the mixture of three commonly used phthalate esters(MPEs)in rats,and further to explore the underlying *** and Methods:Thirty male Sprague-Dawley rats were randomly divided into three *** were orally treated with 160 mg/kg/d MPEs in the MPEs group;coinstantaneously treated with 160 mg/kg/d MPEs and 200 mg/kg/d GM in the MPEs+GM group;and treated with the excipient in the control *** intervention lasted for 5 *** weight,epididymis weight,testicular histopathology,and serum testosterone were detected for testicular toxicity *** testicular ultrastructure,the tight junction proteins zonula occluden(ZO)-1,and claudin were measured for the mechanism ***:The body weight,epididymis,serum testosterone level,and anogenital distance in the MPEs+GM group were significantly decreased compared with control group(P<0.05);Testicular histopathological observation showed that shed spermatids were observed in the MPEs+GM *** observation of testicular cells showed that the cristae number was decreased in some mitochondria in the MPEs group,whereas the cristae were fused and disappeared in most mitochondria in the MPEs+GM *** tight junctions were broken in the MPEs+GM group;meanwhile,the expression of ZO-1 and claudin were altered in the MPEs+GM group(P<0.01).Conclusions:The results from this study indicated that GM aggravated MPEs'testicular toxicity,which might relate to the injured mitochondria and damaged tight junctions in testicular tissue.

关键词： glycerin monostearate butyl benzyl phthalate dibutyl phthalate di(2-ethylhexyl)phthalate male reproductive toxicity tight junction

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Food emulsifier glycerin monostearate enhances phthalates' male reproductive toxicity to rats following chronically integrated exposure

Food emulsifier glycerin monostearate enhances phthalates' m...

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中国营养学会第十次特殊营养学术会议

作者： Hai-Tao GAO Qian XU Qing YU Department of Preventive Medicine School of Public Health and Management Wenzhou Medical University Department of Nutrition and Food Hygiene School of Public Health Southeast University

Human beings are inevitably exposed to ubiquitous phthalates(PEs) surroundings, and simultaneously ingesting a plenty of food emulsifiers via daily diet. The purposes of this study were to explore whether and how food emulsifier glycerin monostearate(GMS) could exacerbate the male reprodcutive toxicity of the mixture of six priority controlled phthalate esters(MIXPs).Male rats were orally administered either sodium carboxymethyl cellulose as controls or MIXPs at 16 mg/kg/d with or without GMS by oral gavage for 15 weeks. Testosterone and luteinizing hormone were analyzed, and histopathological examination of testis were performed for the toxicity evaluation;Steroidogenic proteins(St AR, P450 scc, CYP17A1, 17β-HSD and Arom),tight junction related proteins(claudin and ZO-1) and P-glycoprotein(P-gp) were measured for mechanisms exploration. Results showed that GMS exacerbated the reproductive toxicity of MIXPs, including the decrease of body weight, testicular and serum testosterone level, and the constructional damage of testis. GMS down-regulated the expression of StAR, P450 scc,CYP17A1, 17β-HSD, claudin and ZO-1, while up-regulated the expression of Arom in testis. The results indicated that GMS might damaged the structure and function of tight junction and P-gp efflux system, then enhanced the permeability of PEs and increased their toxicity in rats.

关键词： Food emulsifier glycerin monostearate Phthalate esters Reproductive toxicity Testosterone Tight junction P-glycoprotein

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Food emulsifier glycerin monostearate enhances phthalates' male reproductive toxicity to rats following chronically integrated exposure

Food emulsifier glycerin monostearate enhances phthalates' m...

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2017浙江省营养学会年会暨西湖营养学术论坛

作者： Hai-Tao GAO Qian XU Qing YU Department of Preventive Medicine School of Public Health and ManagementWenzhou Medical University Department of Nutrition and Food Hygiene School of Public HealthSoutheast University

Human beings are inevitably exposed to ubiquitous phthalates(PEs) surroundings,and simultaneously ingesting a plenty of food emulsifiers via daily *** purposes of this study were to explore whether and how food emulsifier glycerin monostearate(GMS) could exacerbate the male reprodcutive toxicity of the mixture of six priority controlled phthalate esters(MIXPs).Male rats were orally administered either sodium carboxymethyl cellulose as controls or MEXPs at 16 mg/kg/d with or without GMS by oral gavage for 15 *** and luteinizing hormone were analyzed,and histopathological examination of testis were performed for the toxicity evaluation;Steroidogenic proteins(StAR,P450 scc,CYP17 A1,17β-HSD and Arom),tight junction related proteins(claudin and ZO-1) and P-glycoprotein(P-gp) were measured for mechanisms *** showed that GMS exacerbated the reproductive toxicity of MIXPs,including the decrease of body weight,testicular and serum testosterone level,and the constructional damage of *** down-regulated the expression of StAR,P450 scc,CYP17 A1,17β-HSD,claudin and ZO-1,while up-regulated the expression of Arom in *** results indicated that GMS might damaged the structure and function of tight junction and P-gp efflux system,then enhanced the permeability of PEs and increased their toxicity in rats.

关键词： Food emulsifier glycerin monostearate Phthalate esters Reproductive toxicity Testosterone Tight junction P-glycoprotein

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