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Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Cellular & Molecular Immunology 2023年第10期20卷 1101-1113页

作者： SaloméS.Pinho Inês Alves Joana Gaifem Gabriel A.Rabinovich i3S–Institute for Research and Innovation in Health University of Porto4200-135PortoPortugal ICBAS-School of Medicine and Biomedical Sciences University of Porto4050-313PortoPortugal Faculty of Medicine University of Porto4200-319PortoPortugal Laboratorio de Glicomedicina Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)C1428Ciudad de Buenos AiresArgentina Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresC1428Ciudad de Buenos AiresArgentina

The immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous *** of these safeguard and homeostatic mechanisms can lead to unpredictable inflammatory and autoimmune responses,whereas deficiency of immune stimulatory pathways may orchestrate immunosuppressive programs that contribute to perpetuate chronic infections,but also influence cancer development and *** have emerged as essential components of homeostatic circuits,acting as fine-tuners of immunological responses and potential molecular targets for manipulation of immune tolerance and activation in a wide range of pathologic *** surface glycans,present in cells,tissues and the extracellular matrix,have been proposed to serve as“self-associated molecular patterns”that store structurally relevant biological *** responsibility of deciphering this information relies on different families of glycan-binding proteins(including galectins,siglecs and C-type lectins)which,upon recognition of specific carbohydrate structures,can recalibrate the magnitude,nature and fate of immune *** process is tightly regulated by the diversity of glycan structures and the establishment of multivalent interactions on cell surface receptors and the extracellular *** we review the spatiotemporal regulation of selected glycan-modifying processes including mannosylation,complex N-glycan branching,core 2 O-glycan elongation,LacNAc extension,as well as terminal sialylation and ***,we illustrate examples that highlight the contribution of these processes to the control of immune responses and their integration with canonical tolerogenic ***,we discuss the power of glycans and glycan-binding proteins as a source of immunomodulatory signals that could be leveraged for the treatment of autoimmune inflammation and chronic infection.

关键词： Immune response Inflammation Infection glycans Glycosylation glycan-binding proteins

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